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GENE：PRKAR1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKAR1A
FullNmae protein kinase cAMP-dependent type I regulatory subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9388
EnsembleID ENSG00000108946
Uniprot P10644

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKAR1A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKAR1A apoptosis 20824711 Silencing PRKAR1A expression induced growth inhibition and apoptosis of CCA cells, with an associated decrease in mitogen-activated protein kinases, PI3K/Akt, JAK/STAT and Wnt/β-catenin pathway signaling. retulator signature

Go Annotation:

GeneSymbol Go id
PRKAR1A GO:0001707,GO:0001772,GO:0004862,GO:0005515,GO:0005737,GO:0005771,GO:0005813,GO:0005829,GO:0005829,GO:0005930,GO:0005952,GO:0006357,GO:0007189,GO:0008603,GO:0010629,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031594,GO:0031625,GO:0032024,GO:0032991,GO:0034236,GO:0035556,GO:0044853,GO:0045214,GO:0046007,GO:0060038,GO:0071377,GO:0097224,GO:0097546,GO:0098978,GO:2000480

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKAR1A hsa:5573 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRKAR1A MTOR 16963469 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKAR1A UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
PRKAR1A CDK4 20005715 interaction type N/A PSP
PRKAR1A ITGA4 20005715 interaction type N/A PSP
PRKAR1A PRKACA 20005715 interaction type N/A PSP
PRKAR1A PRKACA 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
E2F6 PRKAR1A 12909625 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 PRKAR1A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PRKAR1A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRKAR1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRKAR1A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 PRKAR1A 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS0000338542 PRKAR1A 20584899 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection TarBase
URS00000F31F4 PRKAR1A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 PRKAR1A 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000002103A PRKAR1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D PRKAR1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000029D9F1 PRKAR1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016FF9C PRKAR1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C85B2 PRKAR1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000FFC8B PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002D0FC3 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001270D3 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D PRKAR1A 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 PRKAR1A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F PRKAR1A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PRKAR1A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 PRKAR1A 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000028C188 PRKAR1A 25416803 28159925 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK16 PRKAR1A 22135298 phosphorylation N/A PhosphoSite
CDK2 PRKAR1A 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
ARPC3 PRKAR1A 25348397 N/A physical interaction ComPPI
UBE2I PRKAR1A 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ZBED1 PRKAR1A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CBSL PRKAR1A 25348397 N/A physical interaction ComPPI
BCL2L11 PRKAR1A 21151042 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PLEKHF2 PRKAR1A 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ANP32B PRKAR1A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NPM1 PRKAR1A 25348397 N/A physical interaction ComPPI
PRKAR2B PRKAR1A 25348397 N/A physical interaction ComPPI
SET PRKAR1A 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
GABARAPL2 PRKAR1A 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
MAP1LC3B PRKAR1A 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
PRKACB PRKAR1A 23455922 24234451 25348397 association two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
DDIT4L PRKAR1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EGLN3 PRKAR1A 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
GRB2 PRKAR1A 14525934 25348397 9050991 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD2 PRKAR1A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKACA PRKAR1A 11834733 14525934 15655353 17353931 23455922 24234451 24605759 24700472 24855271 25348397 9405392 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,protein kinase assay,in vitro,tandem affinity purification,two hybrid prey pooling approach ComPPI,HPRD,IntAct
PPP1R12A PRKAR1A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
VAPA PRKAR1A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPART PRKAR1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GSK3B PRKAR1A 23602568 24234451 25348397 29568061 association pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
CUL3 PRKAR1A 25348397 N/A physical interaction ComPPI
PAM PRKAR1A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SLC2A4 PRKAR1A 14525934 16396496 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAZ PRKAR1A 25348397 N/A physical interaction ComPPI
PRKAR1A PRKAR1B 12634056 14525934 24234451 25348397 8407966 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKAR1A MYO7A 10889203 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
PRKAR1A PRKX 10026146 14525934 16491121 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKAR1A AKAP4 14525934 25348397 9852104 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
PRKAR1A RFC2 14525934 15096576 15655353 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PRKAR1A AKAP10 14525934 16189514 24234451 25348397 9326583 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid ComPPI,HPRD,IntAct
PRKAR1A AKAP11 10864471 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKAR1A AKAP7 12804576 25348397 27898060 N/A two hybrid,in vivo ComPPI,OmniPath
PRKAR1A PYCARD 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKAR1A CDK2 14525934 16582606 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKAR1A CCNE1 14525934 16582606 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKAR1A CDK4 14525934 16582606 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKAR1A AKAP1 10764601 14525934 24234451 25348397 9065479 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKAR1A ITGA4 14525934 17369818 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKAR1A EGFR 14525934 25348397 9050991 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKAR1A HLA-A 14525934 25348397 6333425 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKAR1A NPRL2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A UBE2M 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A NUAK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A MCRS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A ARFGEF2 12571360 14525934 19332778 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKAR1A ARFGEF1 19332778 24234451 25348397 association,physical association anti bait coimmunoprecipitation,molecular sieving,physical interaction ComPPI,IntAct
PRKAR1A GABARAPL1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PRKAR1A WNK1 25348397 N/A physical interaction ComPPI
PRKAR1A UBC 25348397 N/A physical interaction ComPPI
PRKAR1A PJA2 25348397 N/A physical interaction ComPPI
PRKAR1A CBS 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A NELL2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A WDCP 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A BAHD1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A TAB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A ELAVL1 25348397 N/A physical interaction ComPPI
PRKAR1A PATZ1 20026299 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKAR1A PRPF31 25348397 N/A physical interaction ComPPI
PRKAR1A SAFB 25348397 N/A physical interaction ComPPI
PRKAR1A MEN1 25348397 N/A physical interaction ComPPI
PRKAR1A SLC38A5 25348397 N/A physical interaction ComPPI
PRKAR1A SMURF1 25348397 N/A physical interaction ComPPI
PRKAR1A PPP1CA 25348397 N/A physical interaction ComPPI
PRKAR1A HIVEP1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A CAPN11 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKAR1A SETD7 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR1A DYRK1B 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKAR1A DYRK1A 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKAR1A PFDN5 25348397 N/A physical interaction ComPPI
PRKAR1A AGO2 25348397 N/A physical interaction ComPPI
PRKAR1A AGO3 25348397 N/A physical interaction ComPPI
PRKAR1A CEP250 25348397 N/A physical interaction ComPPI
PRKAR1A MAPT 25348397 N/A physical interaction ComPPI
PRKAR1A RAF1 25348397 N/A physical interaction ComPPI
PRKAR1A CUL7 25348397 N/A physical interaction ComPPI
PRKAR1A CCDC8 25348397 N/A physical interaction ComPPI
PRKAR1A ILK 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A MTOR 25348397 N/A physical interaction ComPPI
PRKAR1A BTRC 25348397 N/A physical interaction ComPPI
PRKAR1A STOML2 25348397 N/A physical interaction ComPPI
PRKAR1A PRKACG 25348397 N/A physical interaction ComPPI
PRKAR1A AKAP2 25348397 N/A physical interaction ComPPI
PRKAR1A AKAP3 25348397 N/A physical interaction ComPPI
PRKAR1A GPR161 25348397 N/A physical interaction ComPPI
PRKAR1A ANKRD26 25348397 N/A physical interaction ComPPI
PRKAR1A FRMD5 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A IFI16 25348397 N/A physical interaction ComPPI
PRKAR1A XPO1 25348397 N/A physical interaction ComPPI
PRKAR1A VAPB 25348397 N/A physical interaction ComPPI
PRKAR1A IQCB1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRKAR1A PDE3A 19332778 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A AICDA 16387847 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PRKAR1A CRB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PRKAR1A RPS17 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A HUWE1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A SSRP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A BEX2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A CDH2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A BRD7 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A STXBP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A TCEAL5 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A CERT1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A XRCC6 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A SLC25A27 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A SPTBN1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A CHMP4B 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A CMTR1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A NCL 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKAR1A GABARAP 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
PRKAR1A MAP1LC3C 20562859 24234451 25348397 N/A pull down ComPPI,IntAct
PRKAR1A TULP3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
PRKAR1A RSPH3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAR1A DTX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAR1A AKAP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAR1A CDIPTOSP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAR1A FAM20C 22582013 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PRKAR1A KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAR1A RRP1B 25348397 N/A tandem affinity purification ComPPI
PRKAR1A CANX 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRPF40A PRKAR1A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
MAPK6 PRKAR1A 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SOX2 PRKAR1A 25348397 N/A physical interaction ComPPI
C2ORF88 PRKAR1A 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKAR1A PRKAR1A 20133847 24234451 N/A bimolecular fluorescence complementation IntAct
CDK2 PRKAR1A 16582606 17287340 18212344 18452278 18669648 18691976 18707149 18767875 19007248 19413330 19415658 19562805 19651622 19664994 20058876 20068231 20166139 27898060 stimulant N/A OmniPath
PRKAR1A MTOR 16963469 27898060 N/A N/A OmniPath
PDE4DIP PRKAR1A 21569246 27898060 stimulant N/A OmniPath
CDK16 PRKAR1A 16582606 25605337 27898060 N/A N/A OmniPath

Visualization










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