Gene Information gene info

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GENE：SPHK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPHK1
FullNmae sphingosine kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11240
EnsembleID ENSG00000176170
Uniprot Q9NYA1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPHK1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SPHK1 apoptosis 37543362 Meanwhile, supplementation with SPHK1 partially reversed oxidative stress-induced apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
SPHK1 GO:0000287,GO:0001568,GO:0003376,GO:0003677,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005905,GO:0006473,GO:0006670,GO:0006954,GO:0007420,GO:0008283,GO:0008289,GO:0008481,GO:0008481,GO:0010800,GO:0010803,GO:0016020,GO:0016310,GO:0016407,GO:0017050,GO:0017050,GO:0017050,GO:0019722,GO:0030100,GO:0030139,GO:0030148,GO:0030307,GO:0030335,GO:0031398,GO:0031901,GO:0032651,GO:0032740,GO:0034612,GO:0035556,GO:0035924,GO:0038036,GO:0043066,GO:0043066,GO:0043066,GO:0043066,GO:0043231,GO:0045766,GO:0045840,GO:0045931,GO:0045987,GO:0046512,GO:0046512,GO:0046512,GO:0046521,GO:0048146,GO:0050764,GO:0051092,GO:0051092,GO:0051721,GO:0070301,GO:0071363,GO:0071897,GO:0098793,GO:0150077,GO:1900060,GO:1900745,GO:1901224,GO:1903978,GO:1905364

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPHK1 hsa:8877 path:hsa00600 Sphingolipid metabolism - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa01100 Metabolic pathways - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04148 Efferocytosis - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
SPHK1 hsa:8877 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRAF6 SPHK1 23180781 24464131 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TRAF2 SPHK1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR SPHK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 SPHK1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 SPHK1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SPHK1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A SPHK1 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SPHK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BTG2 SPHK1 16516161 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A SPHK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE SPHK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004AE8D3 SPHK1 25416803 26549227 27065335 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000054DF42 SPHK1 25416803 27725903 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 SPHK1 22135298 phosphorylation N/A PhosphoSite
MAPK1 SPHK1 22135298 phosphorylation N/A PhosphoSite
CTNND2 SPHK1 25361965 interaction type N/A PTMCode2
SPHK1 CTNND2 25361965 interaction type N/A PTMCode2
SPHK1 CTSB 25361965 interaction type N/A PTMCode2
CTSB SPHK1 25361965 interaction type N/A PTMCode2
SPHK1 RPS6KC1 25361965 interaction type N/A PTMCode2
RPS6KC1 SPHK1 25361965 interaction type N/A PTMCode2
SPHK1 SPHKAP 25361965 interaction type N/A PTMCode2
SPHKAP SPHK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 SPHK1 14525934 17124500 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
LYN SPHK1 14525934 16316995 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
EP300 SPHK1 24234451 24759103 25348397 association physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
FHL2 SPHK1 16888242 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,fluorescence microscopy ComPPI,IntAct
CTSB SPHK1 14525934 15710602 17064696 24234451 25348397 cleavage reaction experimental interaction detection,protease assay,in vitro ComPPI,HPRD,IntAct
EEF1A1 SPHK1 20838377 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
TRAF2 SPHK1 11777919 14525934 25348397 25716317 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
CTNND2 SPHK1 14525934 15193146 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
FYN SPHK1 14525934 16316995 24234451 25348397 N/A anti bait coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
BECN1 SPHK1 25348397 N/A physical interaction ComPPI
DHPS SPHK1 25348397 N/A physical interaction ComPPI
BIRC3 SPHK1 25348397 N/A physical interaction ComPPI
MBTPS1 SPHK1 25348397 N/A physical interaction ComPPI
SPHK1 RPS6KC1 12077123 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SPHK1 SPHKAP 12080051 14525934 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,in vitro,in vivo,confocal microscopy,two hybrid ComPPI,HPRD,IntAct
SPHK1 RARG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SPHK1 PPM1G 25348397 N/A physical interaction ComPPI
SPHK1 CYLD 25348397 N/A physical interaction ComPPI
DCXR SPHK1 25348397 N/A physical interaction ComPPI
SPHK1 H4C1 24234451 24759103 association chromatin immunoprecipitation assay IntAct
SPHK1 SP6 24234451 24759103 association chromatin immunoprecipitation assay IntAct
SPHK1 TRAF6 17124500 24464131 27898060 N/A N/A OmniPath
MAPK3 SPHK1 14532121 15623571 16243846 16522638 18852266 19830907 19914200 21075214 27898060 stimulant N/A OmniPath
MAPK1 SPHK1 14532121 27898060 stimulant N/A OmniPath
PPP2CA SPHK1 18852266 27898060 N/A N/A OmniPath
PPP2CB SPHK1 18852266 27898060 N/A N/A OmniPath

Visualization










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