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GENE：TNFRSF10B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TNFRSF10B
FullNmae TNF receptor superfamily member 10b
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11905
EnsembleID ENSG00000120889
Uniprot O14763

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TNFRSF10B pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF10B necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF10B necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
TNFRSF10B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TNFRSF10B apoptosis 24387758 Silencing of TNFRSF10B or PMAIP1 or overexpression of CFLAR /c-FLIP (long form) could protect cells from PTL-induced apoptosis. retulator signature
TNFRSF10B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TNFRSF10B GO:0002357,GO:0005515,GO:0005886,GO:0005886,GO:0006915,GO:0007166,GO:0007250,GO:0008625,GO:0009986,GO:0009986,GO:0034976,GO:0036462,GO:0036463,GO:0038023,GO:0042981,GO:0043065,GO:0043123,GO:0045569,GO:0070059,GO:0070059,GO:0071260

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TNFRSF10B hsa:8795 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa04210 Apoptosis - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa04217 Necroptosis - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa05132 Salmonella infection - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa05164 Influenza A - Homo sapiens (human)
TNFRSF10B hsa:8795 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JUN TNFRSF10B 11274345 17439715 23430059 23850759 26192618 26587781 8545107 interaction type N/A ACSN
TNFRSF10B TNFSF10 10894161 16227629 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B TRAF2 12721308 23180781 physical association gst pull down InnateDB
TNFRSF10B FADD 12721308 15452120 23180781 physical association anti tag coimmunoprecipitation,two hybrid,gst pull down InnateDB
TNFRSF10B TP53 16990795 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B NFKB2 16990795 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B IRF5 19028697 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B CASP8 12721308 17047155 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
TNFRSF10B BCL6 19965633 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B PRDM1 20421211 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP8 TNFRSF10B 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFRSF10B HNRNPA1 23180781 24120475 physical association anti tag coimmunoprecipitation,confocal microscopy InnateDB
TNFRSF10B ILF2 23180781 24120475 physical association anti tag coimmunoprecipitation,confocal microscopy InnateDB
TNFRSF10B DDX5 23180781 24120475 physical association anti tag coimmunoprecipitation,confocal microscopy InnateDB
TNFRSF10B ILF3 23180781 24120475 physical association anti tag coimmunoprecipitation,confocal microscopy InnateDB
TNFRSF10B DROSHA 23180781 24120475 physical association anti tag coimmunoprecipitation,confocal microscopy InnateDB
TNFRSF10B DGCR8 23180781 24120475 physical association anti tag coimmunoprecipitation,confocal microscopy InnateDB

Source Target Pmid Interactiontype Methods Database
FADD TNFRSF10B 20005715 interaction type N/A PSP
TRADD TNFRSF10B 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
DDIT3 TNFRSF10B 15322075 15994939 18172319 18593935 18794136 20157774 21044953 21726997 21941003 22328338 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
ETS1 TNFRSF10B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C TNFRSF10B 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 TNFRSF10B 20953172 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 TNFRSF10B 10101800 10810622 11313989 11756185 15964798 18971253 19351839 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TNFRSF10B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 TNFRSF10B 21044953 trascriptional regulation,stimulation inferred by curator TFlink
ATM TNFRSF10B 19351839 trascriptional regulation,stimulation inferred by curator TFlink
DNMT1 TNFRSF10B 20398055 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 TNFRSF10B 21044953 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 TNFRSF10B 21135115 trascriptional regulation,stimulation inferred by curator TFlink
GLI2 TNFRSF10B 21135115 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 TNFRSF10B 15964798 trascriptional regulation,stimulation inferred by curator TFlink
MYC TNFRSF10B 15144957 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TNFRSF10B 18523266 18599488 19351839 trascriptional regulation,stimulation inferred by curator TFlink
RELA TNFRSF10B 18523266 18599488 19351839 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 TNFRSF10B 22483777 trascriptional regulation,stimulation inferred by curator TFlink
SP1 TNFRSF10B 18097593 20354117 20515942 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TNFRSF10B 18097593 20354117 20515942 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 TNFRSF10B 19351839 trascriptional regulation,stimulation inferred by curator TFlink
YY1 TNFRSF10B 17431117 17530016 18778787 trascriptional regulation,stimulation inferred by curator TFlink
MYB TNFRSF10B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 TNFRSF10B 18668040 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS0000007FBA TNFRSF10B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000041FA2C TNFRSF10B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC TNFRSF10B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002075FA TNFRSF10B 21572407 22012620 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00003D4175 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D TNFRSF10B 22473208 25118289 25416803 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS000029979D TNFRSF10B 24120475 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000000B1C9 TNFRSF10B 24120475 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS00000A07C1 TNFRSF10B 24120475 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000031E12 TNFRSF10B 24120475 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000324096 TNFRSF10B 24120475 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS0000137EDE TNFRSF10B 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019907A TNFRSF10B 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006FDD4 TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000031602A TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000251D0B TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C11BC TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C0FCB TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000315338 TNFRSF10B 23446348 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000049FAE8 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 TNFRSF10B 21572407 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TNFRSF10B 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005606AA TNFRSF10B 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000002CF68 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000048BA36 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004818BD TNFRSF10B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 TNFRSF10B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003BF62 TNFRSF10B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 TNFRSF10B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F TNFRSF10B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 TNFRSF10B 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 TNFRSF10B 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00003883FE TNFRSF10B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037D7E5 TNFRSF10B 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000003E1A9 TNFRSF10B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008DA94 TNFRSF10B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004977C5 TNFRSF10B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000D5659 TNFRSF10B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 TNFRSF10B 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C02E4 TNFRSF10B 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STX12 TNFRSF10B 25348397 N/A physical interaction ComPPI
ARRDC3 TNFRSF10B 25348397 N/A physical interaction ComPPI
TNFAIP3 TNFRSF10B 25348397 N/A physical interaction ComPPI
RAC1 TNFRSF10B 24234451 25348397 25843002 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
SCAMP1 TNFRSF10B 25348397 N/A physical interaction ComPPI
SLC1A1 TNFRSF10B 25348397 N/A physical interaction ComPPI
PAK1 TNFRSF10B 24234451 25348397 25843002 association pull down ComPPI,IntAct
CBL TNFRSF10B 25348397 N/A physical interaction ComPPI
CBLB TNFRSF10B 25348397 N/A physical interaction ComPPI
MAPK8 TNFRSF10B 25348397 N/A physical interaction ComPPI
RHOA TNFRSF10B 25348397 N/A physical interaction ComPPI
ARHGDIA TNFRSF10B 25348397 N/A physical interaction ComPPI
CUL3 TNFRSF10B 25348397 N/A physical interaction ComPPI
DDR1 TNFRSF10B 25348397 N/A physical interaction ComPPI
IFNGR1 TNFRSF10B 25348397 N/A physical interaction ComPPI
CKAP4 TNFRSF10B 25348397 N/A physical interaction ComPPI
CASP8 TNFRSF10B 12218097 14525934 17047155 20103630 24234451 25043603 25348397 colocalization,association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
TNFRSF1A TNFRSF10B 25348397 N/A physical interaction ComPPI
FADD TNFRSF10B 14525934 24234451 25043603 25348397 9430227 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TRAF2 TNFRSF10B 25348397 N/A physical interaction ComPPI
EGFR TNFRSF10B 25348397 N/A physical interaction ComPPI
FASLG TNFRSF10B 25348397 N/A physical interaction ComPPI
FGFR1 TNFRSF10B 25348397 N/A physical interaction ComPPI
VAMP3 TNFRSF10B 25348397 N/A physical interaction ComPPI
ITCH TNFRSF10B 25348397 N/A physical interaction ComPPI
CASP10 TNFRSF10B 25348397 N/A physical interaction ComPPI
RIPK1 TNFRSF10B 14525934 25348397 9430227 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MADD TNFRSF10B 14525934 15208670 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MSN TNFRSF10B 25348397 N/A physical interaction ComPPI
STX3 TNFRSF10B 25348397 N/A physical interaction ComPPI
FYN TNFRSF10B 25348397 N/A physical interaction ComPPI
CFLAR TNFRSF10B 11193041 11940602 14525934 19343040 23142077 25348397 27898060 9325248 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PTRH2 TNFRSF10B 25348397 N/A physical interaction ComPPI
TRIM25 TNFRSF10B 25348397 N/A physical interaction ComPPI
TRADD TNFRSF10B 14525934 25348397 9430227 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UGCG TNFRSF10B 25348397 N/A physical interaction ComPPI
LTBR TNFRSF10B 25348397 N/A physical interaction ComPPI
TNFRSF13B TNFRSF10B 25348397 N/A physical interaction ComPPI
ASIC1 TNFRSF10B 25348397 N/A physical interaction ComPPI
TNFRSF10A TNFRSF10B 14525934 16319225 19427028 24234451 25348397 9430228 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
TNFRSF10B TNFSF10 10542098 10549288 10894160 14525934 19427028 20097879 20103630 21459798 21525171 21822306 22266862 23678861 24234451 25348397 9311998 9325248 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TNFRSF10B TNFRSF10D 14525934 16319225 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TNFRSF10B BID 25348397 N/A physical interaction ComPPI
TNFRSF10B EZR 25348397 N/A physical interaction ComPPI
TNFRSF10B FAS 25348397 N/A physical interaction ComPPI
TNFRSF10B TIMM50 25348397 N/A physical interaction ComPPI
TNFRSF10B TSPAN3 25348397 N/A physical interaction ComPPI
TNFRSF10B TMEM231 25348397 N/A physical interaction ComPPI
TNFRSF10B GINM1 25348397 N/A physical interaction ComPPI
TNFRSF10B MICA 25348397 N/A physical interaction ComPPI
TNFRSF10B LSR 25348397 N/A physical interaction ComPPI
TNFRSF10B NDFIP1 25348397 N/A physical interaction ComPPI
TNFRSF10B FLVCR1 25348397 N/A physical interaction ComPPI
TNFRSF10B MFAP3 25348397 N/A physical interaction ComPPI
TNFRSF10B TMEM214 25348397 N/A physical interaction ComPPI
TNFRSF10B SLC15A4 25348397 N/A physical interaction ComPPI
TNFRSF10B REEP5 25348397 N/A physical interaction ComPPI
TNFRSF10B LAPTM4B 25348397 N/A physical interaction ComPPI
TNFRSF10B RNF149 25348397 N/A physical interaction ComPPI
TNFRSF10B PRAF2 25348397 N/A physical interaction ComPPI
TNFRSF10B HEPACAM2 25348397 N/A physical interaction ComPPI
TNFRSF10B TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TNFRSF10B LRRIQ1 25348397 N/A physical interaction ComPPI
TNFRSF10B SLC20A1 25348397 N/A physical interaction ComPPI
TNFRSF10B TMEM223 25348397 N/A physical interaction ComPPI
TNFRSF10B RNF11 25348397 N/A physical interaction ComPPI
TNFRSF10B IL1R1 25348397 N/A physical interaction ComPPI
TNFRSF10B A1BG 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
TNFRSF10B ARAP1 18165900 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TNFRSF10B ZDHHC15 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNFRSF10B BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TNFRSF10B TRAF2 12721308 22585859 23142077 27898060 N/A N/A OmniPath
TNFRSF10B FADD 11376335 11940602 12721308 12920112 14585074 15173180 15388581 15452120 15659383 16980609 17585340 21272366 23142077 26186194 27898060 9430227 9430228 stimulant N/A OmniPath
FADD TNFRSF10B 11376335 11940602 12721308 12920112 15173180 15388581 15452120 15659383 16980609 17585340 21272366 23142077 26186194 27898060 9430227 9430228 N/A N/A OmniPath
TP53 TNFRSF10B 11498783 27898060 stimulant N/A OmniPath
TNFRSF10B TRADD 27898060 9430227 9430228 stimulant N/A OmniPath
TNFRSF10B CASP8 11940602 12218097 12721308 15388581 15659383 17047155 19343040 22421964 23142077 26186194 27898060 9325248 stimulant N/A OmniPath
CASP8 TNFRSF10B 11940602 12218097 12721308 15388581 15659383 17047155 19343040 22421964 23142077 26186194 27898060 9325248 N/A N/A OmniPath
TNFSF10 TNFRSF10B 10542098 10549288 10894161 11094155 12628743 14585074 15538968 15766588 16227629 20103630 21822306 22585859 27898060 9242610 9311998 9325248 stimulant N/A OmniPath
TNFRSF10B RIPK1 22585859 27898060 9430227 stimulant N/A OmniPath
TNFRSF10A TNFRSF10B 15388581 16319225 16980609 19427028 27898060 9430228 stimulant N/A OmniPath

Visualization










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