Gene Information gene info

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GENE：SMAD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMAD1
FullNmae SMAD family member 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6767
EnsembleID ENSG00000170365
Uniprot Q15797

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMAD1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SMAD1 GO:0000165,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001503,GO:0001657,GO:0001710,GO:0002051,GO:0003161,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005634,GO:0005637,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0006357,GO:0006366,GO:0006954,GO:0007165,GO:0007179,GO:0007179,GO:0007276,GO:0008285,GO:0009653,GO:0009880,GO:0010628,GO:0016020,GO:0017151,GO:0019901,GO:0030154,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030901,GO:0030902,GO:0031053,GO:0031625,GO:0032991,GO:0042592,GO:0042802,GO:0045669,GO:0045944,GO:0045944,GO:0046872,GO:0051148,GO:0051216,GO:0060038,GO:0060348,GO:0060395,GO:0060395,GO:0060395,GO:0060395,GO:0060395,GO:0061036,GO:0070410,GO:0070411,GO:0070411,GO:0070878,GO:0071141,GO:0071142,GO:0071144,GO:0071407,GO:1901522,GO:1902895,GO:1903672

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMAD1 hsa:4086 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
SMAD1 hsa:4086 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
SMAD1 hsa:4086 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
SMAD1 hsa:4086 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL9 SMAD1 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 26192618 7542250 8666229 interaction type N/A ACSN
TCF4 SMAD1 10391247 11955436 11967263 12051714 15001769 15082531 15576399 16039586 17143292 17936032 19619488 20705860 22290435 22761862 23343194 24023259 25730849 26192618 7542250 8666229 interaction type N/A ACSN
SMAD1 MYC 15576399 22290435 22761862 26192618 interaction type N/A ACSN
SMAD1 SQSTM1 15761153 23180781 physical association luminescence based mammalian interactome mapping InnateDB
SMAD2 SMAD1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 SMAD1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD1 FOXP3 20676092 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD1 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD1 ZNF8 15231748 23180781 physical association two hybrid InnateDB
ZNF512B SMAD1 15231748 23180781 physical association two hybrid InnateDB
APP SMAD1 21832049 23180781 physical association protein array InnateDB
SMAD1 SMAD1 19734454 20957627 21454478 22298955 26467481 phosphorylation reaction,bind,up-regulates N/A Signor
MAPK3 SMAD1 23331499 9335504 stimulation N/A SignaLink,SignaLink
SMAD6 SMAD1 11483516 12857866 18988627 21071413 23331499 9256479 9335505 stimulation N/A SignaLink,SignaLink
ACVR1 SMAD1 10085121 10583507 10652350 18988627 23331499 9136927 9748228 stimulation N/A SignaLink,SignaLink
ACVRL1 SMAD1 23331499 9748228 stimulation N/A SignaLink,SignaLink
BMPR1B SMAD1 23331499 9766532 stimulation N/A SignaLink,SignaLink
SMAD1 SMAD4 10531362 14534577 15231748 15761153 18988627 21071413 21454478 23331499 stimulation N/A SignaLink,SignaLink
PPM1A SMAD1 16931515 23331499 stimulation N/A SignaLink,SignaLink
ZRANB2 SMAD1 22021003 interaction type,inhibition N/A SignaLink
TGFB1I1 SMAD1 21996749 interaction type,inhibition N/A SignaLink
SMURF2 SMAD1 11016919 11158580 14701756 15221015 15231748 23331499 stimulation N/A SignaLink
HIPK2 SMAD1 12874272 23331499 stimulation N/A SignaLink
CTDSP1 SMAD1 16882717 23331499 stimulation N/A SignaLink
CTDSP2 SMAD1 16882717 23331499 stimulation N/A SignaLink
GSK3B SMAD1 18045539 23331499 stimulation N/A SignaLink
SMURF1 SMAD1 14701756 14711801 15221015 17289590 23331499 interaction type N/A SignaLink
NOTCH1 SMAD1 14597575 23331499 stimulation N/A SignaLink
SMAD1 DVL1 16621789 23331499 stimulation N/A SignaLink
Q9W629 SMAD1 10354489 10590480 21559328 stimulation N/A SignaFish
Q9DGR6 SMAD1 10590480 17999625 21559328 inhibition N/A SignaFish
B0EXP6 SMAD1 10590480 12050147 21559328 stimulation N/A SignaFish
B3DJ37 SMAD1 10590480 11165484 21559328 stimulation N/A SignaFish
O93369 SMAD1 10590480 stimulation N/A SignaFish
SMAD1 Q9I9P4 10531362 14534577 15231748 15761153 21454478 21559328 stimulation N/A SignaFish

Source Target Pmid Interactiontype Methods Database
AR SMAD1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 SMAD1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SMAD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA1 SMAD1 22036566 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 SMAD1 20427544 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000065D58 SMAD1 22253433 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00002152A8 SMAD1 22253433 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000005CF5F SMAD1 22253433 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000338542 SMAD1 18668040 20427544 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000065D58 SMAD1 22253433 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00002152A8 SMAD1 22253433 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000005CF5F SMAD1 22253433 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000016914 SMAD1 23800974 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000027464B SMAD1 24532688 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004977C5 SMAD1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 SMAD1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D SMAD1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 SMAD1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 SMAD1 25416803 27027434 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK7 SMAD1 22135298 phosphorylation N/A PhosphoSite
BMPR1B SMAD1 22135298 phosphorylation N/A PhosphoSite
GSK3B SMAD1 22135298 phosphorylation N/A PhosphoSite
MAPK1 SMAD1 22135298 phosphorylation N/A PhosphoSite
CDK9 SMAD1 22135298 phosphorylation N/A PhosphoSite
CDK8 SMAD1 22135298 phosphorylation N/A PhosphoSite
ATM SMAD1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SMARCE1 SMAD1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ZCCHC12 SMAD1 18160706 19416967 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTDSP2 SMAD1 16882717 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SKIL SMAD1 12426322 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CCND1 SMAD1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
LMNA SMAD1 25348397 N/A physical interaction ComPPI
RAN SMAD1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 SMAD1 11779505 14525934 15231748 15761153 17183365 24234451 24412244 25348397 9436979 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,molecular sieving,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
ZNF512B SMAD1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SNIP1 SMAD1 10887155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ERBB2 SMAD1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
PAK1 SMAD1 25348397 N/A in vivo ComPPI
ERBIN SMAD1 25348397 N/A physical interaction,in vitro ComPPI
SMURF2 SMAD1 11016919 14525934 14701756 15231748 20937913 24234451 25348397 physical association two hybrid,experimental interaction detection,nuclear magnetic resonance,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
TOB1 SMAD1 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FOXG1 SMAD1 11387330 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD1 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 GLI3 14525934 24234451 25241761 25348397 9843199 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
SMAD1 ZBTB44 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD1 TTF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 KMT2D 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 SF3B1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 RFX1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 ZSCAN4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 PSMD11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 SOX5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 CHMP3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 TTF1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 AP2A2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 EWSR1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD1 STARD13 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 INPP4A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 AKR1B1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 PIGQ 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 PUM1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 ANKRD27 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 CILK1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 ZDHHC3 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 ZNF510 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 PSMD1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 ZNF76 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 HBP1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 SNRNP70 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 ACVR1 10085121 10583507 10652350 14525934 25348397 9136927 9748228 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD1 BMPR1A 11438941 14525934 24234451 24412244 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo ComPPI,HPRD,IntAct
SMAD1 XPO1 12519765 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD1 EP300 10673036 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD1 SMAD6 11483516 14525934 24234451 25348397 9436979 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD1 MED6 12167862 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD1 ZNF423 10660046 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD1 ZEB2 10400677 12714599 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 HIPK2 12874272 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD1 GDF6 14525934 15246821 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD1 NEDD9 11118211 14525934 15231748 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
SMAD1 ECSIT 14525934 14633973 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 ZNF521 14525934 14630787 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD1 MAPK1 14525934 25348397 9335504 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD1 ARHGEF6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 BTBD2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 EIF2AK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 ELP3 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 FBXL12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 FBXO30 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 FHL5 25348397 N/A in vivo ComPPI
SMAD1 GSC 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 ING2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 NAT9 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 PLEKHB1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 PREB 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAB2B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAB30 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAB34 25348397 N/A in vivo ComPPI
SMAD1 RAB38 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAB3B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAB6B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAC2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RAP2A 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RASD2 25348397 N/A in vivo ComPPI
SMAD1 RASL12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RHEBL1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 RHOG 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 SMAD3 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD1 SMURF1 14525934 14701756 15231748 15761153 19914168 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
SMAD1 SQSTM1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 STUB1 14525934 14701756 15708501 15761153 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD1 TNNT1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 TRIP6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 UBC 18567580 20956305 25348397 27898060 N/A physical interaction,in vivo ComPPI,OmniPath
SMAD1 UBA52 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 VEPH1 25348397 N/A in vivo ComPPI
SMAD1 LEMD3 14525934 15231748 15489854 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SMAD1 KAT2B 14500836 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 UBE2Z 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 UBXN1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 HOXA13 14525934 16087734 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD1 HOXD13 25348397 N/A two hybrid,in vivo ComPPI
SMAD1 COL4A1 14732718 25348397 27898060 N/A two hybrid,in vivo ComPPI,OmniPath
SMAD1 SUV39H1 14525934 15107829 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 AR 14525934 17183365 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,protein complementation assay,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
SMAD1 MEN1 12649288 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD1 HOXC8 10224145 11139569 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SMAD1 PIAS1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 XPC 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 PIAS4 12904571 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 MBD1 14525934 15231748 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SMAD1 NOTCH2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 GMEB1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD1 SKI 25348397 N/A physical interaction ComPPI
SMAD1 ZEB1 25348397 N/A physical interaction ComPPI
SMAD1 DVL1 25348397 N/A physical interaction ComPPI
SMAD1 DVL1P1 25348397 N/A physical interaction ComPPI
SMAD1 TGIF1 25348397 N/A physical interaction ComPPI
SMAD1 CREBBP 25348397 N/A physical interaction ComPPI
SMAD1 STAT3 25348397 N/A physical interaction ComPPI
SMAD1 RUNX2 25348397 N/A physical interaction ComPPI
SMAD1 RUNX1 25348397 N/A physical interaction ComPPI
SMAD1 RUNX3 25348397 N/A physical interaction ComPPI
SMAD1 OAZ3 25348397 N/A physical interaction ComPPI
SMAD1 HOXA5 25348397 N/A physical interaction ComPPI
SMAD1 TCF20 25348397 N/A physical interaction ComPPI
SMAD1 SS18L1 25348397 N/A physical interaction ComPPI
SMAD1 WWP1 25348397 N/A physical interaction ComPPI
SMAD1 NKX3-2 25348397 N/A physical interaction ComPPI
SMAD1 YY1 25348397 N/A physical interaction ComPPI
SMAD1 MED15 12167862 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD1 MED24 12167862 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD1 MECOM 25348397 N/A physical interaction ComPPI
SMAD1 HMGA2 25348397 N/A physical interaction ComPPI
SMAD1 KAT2A 25348397 N/A physical interaction ComPPI
SMAD1 OAZ1 25348397 N/A physical interaction ComPPI
SMAD1 HDAC1 25348397 N/A physical interaction ComPPI
SMAD1 KDM6B 25348397 N/A physical interaction ComPPI
SMAD1 NUP214 25348397 N/A physical interaction ComPPI
SMAD1 FOXO3 25348397 N/A physical interaction ComPPI
SMAD1 UCHL3 21453705 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
SMAD1 FRZB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 USP9X 25348397 N/A physical interaction ComPPI
SMAD1 NEDD4 15231748 21308777 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
SMAD1 USP15 25348397 N/A physical interaction ComPPI
SMAD1 CDK8 19914168 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD1 CDK7 25348397 N/A physical interaction ComPPI
SMAD1 CDK9 25348397 N/A physical interaction ComPPI
SMAD1 YAP1 19914168 24234451 25348397 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,physical interaction ComPPI,IntAct
SMAD1 HGS 25348397 N/A physical interaction ComPPI
SMAD1 PAX6 25348397 N/A physical interaction ComPPI
SMAD1 SMAD2 25348397 N/A physical interaction ComPPI
SMAD1 PPM1A 25348397 N/A physical interaction ComPPI
SMAD1 TP53 25348397 N/A physical interaction ComPPI
SMAD1 APP 25348397 N/A physical interaction ComPPI
SMAD1 MAST4 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 CAMSAP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 IRF2BP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 MGA 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 PRR35 25348397 N/A physical interaction ComPPI
SMAD1 ZNF251 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 MRTFB 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD1 GSK3B 18045539 24234451 25241761 25348397 phosphorylation reaction,physical association physical interaction,protein kinase assay,proximity ligation assay ComPPI,IntAct
SMAD1 ACVRL1 25348397 N/A physical interaction ComPPI
SMAD1 WDR77 25348397 N/A physical interaction ComPPI
SMAD1 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD1 PARD3 25348397 N/A physical interaction ComPPI
SMAD1 SMAD7 25348397 N/A physical interaction ComPPI
SMAD1 DNMT3L 25348397 N/A physical interaction ComPPI
SMAD1 DDX5 18548003 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMAD1 DROSHA 18548003 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMAD1 CTDSP1 16882717 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD1 CTDSPL 16882717 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD1 TUBA4A 17183365 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD1 CCNT1 19914168 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
SMAD1 CCNC 19914168 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
SMAD1 APC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 AXIN2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 CTNNA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 DLC1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 FBXW7 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 MLH1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 MSH2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 MUTYH 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 NRAS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 PDGFRL 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 PTPN12 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 TLR2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
UBB SMAD1 25348397 N/A in vivo ComPPI
RPS27A SMAD1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BTG2 SMAD1 14525934 15542835 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NEUROG1 SMAD1 11239394 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ARL4D SMAD1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSMB4 SMAD1 11438941 11571290 12097147 14525934 15231748 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
TGFBR1 SMAD1 10085121 14525934 9136927 9748228 N/A experimental interaction detection HPRD
SMAD1 ZNF8 12370310 14525934 N/A experimental interaction detection,two hybrid HPRD
SMAD1 SMAD1 11016919 11779505 14525934 15231748 15246821 24234451 physical association two hybrid,cosedimentation through density gradient,experimental interaction detection,molecular sieving,x-ray crystallography,two hybrid HPRD,IntAct
YAP1 SMAD1 19914168 21685363 23431053 27898060 stimulant N/A OmniPath
CDK9 SMAD1 19914161 19914168 27898060 inhibition,stimulant N/A OmniPath
ATM SMAD1 22588298 27898060 stimulant N/A OmniPath
PPM1A SMAD1 16931515 27898060 inhibition,stimulant N/A OmniPath
MAPK3 SMAD1 10197981 27898060 9335504 inhibition,stimulant N/A OmniPath
EP300 SMAD1 10205054 10673036 12419246 16613856 20851880 22298955 27898060 stimulant N/A OmniPath
MAPK1 SMAD1 10085121 17289590 18045539 19914161 19914168 27898060 9335504 9748228 inhibition N/A OmniPath
NOTCH1 SMAD1 14597575 27898060 stimulant N/A OmniPath
PPP2CA SMAD1 19339557 27898060 N/A N/A OmniPath
SMAD1 DVL1 16621789 27898060 stimulant N/A OmniPath
SMAD1 SMAD4 10531362 11700304 11779505 12167862 12874272 14701756 15231748 15761153 17183365 20957627 21454478 24412244 26555259 27898060 9111321 9436979 stimulant N/A OmniPath
HIPK2 SMAD1 12874272 27898060 inhibition,stimulant N/A OmniPath
STUB1 SMAD1 14701756 15708501 15761153 21454478 22298955 23344957 27898060 inhibition N/A OmniPath
GSK3B SMAD1 18045539 25241761 27898060 inhibition,stimulant N/A OmniPath
TGFBR1 SMAD1 10085121 19651622 27898060 9136927 9748228 stimulant N/A OmniPath
SMAD1 RUNX2 10531362 10962029 17215250 19734454 20851880 22298955 27898060 stimulant N/A OmniPath
BMPR1A SMAD1 11438941 19620713 24412244 27898060 9136927 stimulant N/A OmniPath
SMAD7 SMAD1 17438144 27898060 inhibition N/A OmniPath
BMPR1B SMAD1 10085121 19620713 27898060 9136927 9335504 9748228 stimulant N/A OmniPath
SKIL SMAD1 12419246 12426322 27898060 inhibition N/A OmniPath
ACVR1 SMAD1 10085121 10583507 10652350 19651622 27898060 9136927 9748228 stimulant N/A OmniPath
BMP2 SMAD1 22298955 27898060 stimulant N/A OmniPath
SMURF2 SMAD1 11016919 11158580 14701756 15221015 15231748 20937913 20956305 22298955 23969857 27898060 inhibition,stimulant N/A OmniPath
SMAD6 SMAD1 11483516 12857866 27898060 9256479 9335505 9436979 inhibition,stimulant N/A OmniPath
SMURF1 SMAD1 14701756 14711801 15221015 15231748 15761153 16611643 17289590 17510966 17676934 19914168 19917253 21685363 21708152 22152476 22298955 22670624 24828823 27898060 inhibition N/A OmniPath
CDK8 SMAD1 19914161 19914168 27898060 inhibition,stimulant N/A OmniPath
SKI SMAD1 12419246 12426322 12874272 14699069 27898060 inhibition N/A OmniPath
ACVRL1 SMAD1 27898060 9748228 inhibition,stimulant N/A OmniPath
MINK1 SMAD1 21690388 27898060 N/A N/A OmniPath
CTDSPL SMAD1 16882717 17085434 27898060 inhibition N/A OmniPath
PDP1 SMAD1 16510868 27898060 inhibition N/A OmniPath
CTDSP1 SMAD1 16882717 17085434 27898060 inhibition N/A OmniPath
PDP2 SMAD1 16510868 27898060 inhibition N/A OmniPath
CTDSP2 SMAD1 16882717 17085434 27898060 inhibition N/A OmniPath
PPP2CB SMAD1 19339557 27898060 N/A N/A OmniPath

Visualization










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