GENE：GDF5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GDF5 |
| FullNmae | growth differentiation factor 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4220 |
| EnsembleID | ENSG00000125965 |
| Uniprot | P43026 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GDF5 | apoptosis | 19782107 | GDF5 and BMP2, members of the TGF-beta superfamily of growth factors, are known to regulate apoptosis in different cell types either positively or negatively. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GDF5 | GO:0002062,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005886,GO:0007179,GO:0007267,GO:0008083,GO:0009612,GO:0030326,GO:0030513,GO:0032331,GO:0032332,GO:0035136,GO:0035137,GO:0036122,GO:0040014,GO:0042802,GO:0043524,GO:0043932,GO:0045666,GO:0050680,GO:0060390,GO:0060395,GO:0060591,GO:0097152,GO:2001054 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GDF5 | hsa:8200 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| GDF5 | hsa:8200 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| GDF5 | hsa:8200 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GDF5 | BMPR2 | 16446785 18342887 23180781 23331499 9525338 | stimulation,physical association | surface plasmon resonance | InnateDB,SignaLink |
| EGR1 | GDF5 | 19032775 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| GDF5 | ACVR2B | 16446785 23331499 8702914 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | GDF5 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SMARCA4 | GDF5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GDF5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | GDF5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | GDF5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DEAF1 | GDF5 | 24861163 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | GDF5 | 24861163 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | GDF5 | 24861163 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | GDF5 | 24861163 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | GDF5 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | GDF5 | 24577233 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000028BB8 | GDF5 | 25416803 27556448 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00000EED18 | GDF5 | 25416803 27385596 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMPR1B | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | BMPR1B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| BMPR1A | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | BMPR1A | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2A | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | BMPR2 | 25361965 | interaction type | N/A | PTMCode2 |
| BMPR2 | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR1 | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | ACVR1 | 25361965 | interaction type | N/A | PTMCode2 |
| HTRA1 | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | HTRA1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CRYAB | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| CALML3 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| CRABP2 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| SNRK | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| SERPINB13 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| SERPINB2 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| BMPR2 | GDF5 | 19229295 24234451 25348397 | N/A | surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,IntAct |
| RAB3IL1 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| RAB3IP | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP14 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| BMPR1B | GDF5 | 16127465 19229295 24234451 25348397 | N/A | surface plasmon resonance,x-ray crystallography,physical interaction,in vitro | ComPPI,IntAct |
| PLCD1 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | GDF5 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| CALML5 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| PKP3 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| FABP4 | GDF5 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR1 | GDF5 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| GDF5 | BMPR1A | 16127465 19229295 24234451 25348397 | N/A | surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,IntAct |
| GDF5 | HTRA1 | 25348397 | N/A | in vitro | ComPPI |
| GDF5 | ACVR2A | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| GDF5 | RPS6KB2 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | TMEM102 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | LRRC15 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | SERPINB7 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | VSIG8 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | SELENBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | SERPINB5 | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | KPRP | 25348397 | N/A | physical interaction | ComPPI |
| GDF5 | NOG | 16127465 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| GDF5 | GDF5 | 24234451 25174448 | N/A | surface plasmon resonance | IntAct |
| GDF5 | PSIP1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| GDF5 | ROR2 | 15569154 27898060 | stimulant | N/A | OmniPath |
| NOG | GDF5 | 16127465 19956691 21976273 27898060 | inhibition | N/A | OmniPath |