GENE:FST
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FST |
| FullNmae | follistatin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3971 |
| EnsembleID | ENSG00000134363 |
| Uniprot | P19883 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FST | apoptosis | 34001106 | FST inhibited the apoptosis of mesenchymal cells by targeting BMP7. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FST | GO:0000122,GO:0001501,GO:0002244,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0007275,GO:0007276,GO:0007389,GO:0008585,GO:0014070,GO:0030154,GO:0030509,GO:0030510,GO:0030857,GO:0031069,GO:0032926,GO:0032926,GO:0032926,GO:0036305,GO:0038102,GO:0042475,GO:0043395,GO:0043616,GO:0048185,GO:0048185,GO:0051798 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FST | hsa:10468 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FST | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | FST | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | FST | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | FST | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| RELA | FST | 18226221 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | FST | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | FST | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | FST | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BRCA1 | FST | 22685544 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTNNB1 | FST | 24667650 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GLI2 | FST | 18319260 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | FST | 24330518 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF7L2 | FST | 24667650 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TCF4 | FST | 24667650 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HOXA1 | FST | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CATSPER1 | FST | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TK1 | FST | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| ADAM12 | FST | 25348397 | N/A | far western blotting | ComPPI |
| ZNF587 | FST | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TXN | FST | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| BMPR2 | FST | 25348397 | N/A | physical interaction | ComPPI |
| ANG | FST | 17991437 24234451 25348397 27898060 | colocalization,physical association | two hybrid,fluorescent resonance energy transfer,pull down,confocal microscopy | ComPPI,IntAct,OmniPath |
| BMPR1A | FST | 25348397 | N/A | physical interaction | ComPPI |
| INHBA | FST | 14525934 25348397 7887917 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| FST | BMP5 | 11580864 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| FST | INHBE | 12242034 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| FST | MEST | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| FST | C8ORF33 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| FST | ADAM8 | 15574124 24234451 25348397 | N/A | far western blotting | ComPPI,IntAct |
| FST | FSTL1 | 20860622 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| FST | DIP2A | 20860622 24234451 25348397 | physical association | surface plasmon resonance,competition binding,surface plasmon resonance array | ComPPI,IntAct |
| FST | BEX2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| INHA | FST | 14525934 2036994 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| FN1 | FST | 14525934 16336961 | N/A | experimental interaction detection | HPRD |
| FST | KDM5B | 24234451 24937458 | association | chromatin immunoprecipitation assay | IntAct |
| NPM1 | FST | 24234451 30021884 | physical association | cross-linking study | IntAct |
| CREB1 | FST | 17482756 27898060 | stimulant | N/A | OmniPath |
| FST | INHBA | 22037168 27898060 7887917 | inhibition | N/A | OmniPath |
