GENE:E2F5
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | E2F5 |
FullNmae | E2F transcription factor 5 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:3119 |
EnsembleID | ENSG00000133740 |
Uniprot | Q15329 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
E2F5 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
E2F5 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
E2F5 | GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001216,GO:0001650,GO:0003700,GO:0005515,GO:0005654,GO:0005654,GO:0005730,GO:0006357,GO:0030030,GO:0043231,GO:0045893,GO:0046983,GO:0090575 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
E2F5 | hsa:1875 | path:hsa04110 | Cell cycle - Homo sapiens (human) |
E2F5 | hsa:1875 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
E2F5 | hsa:1875 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
E2F5 | DIRAS3 | 16638845 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
E2F5 | EGR1 | 20690147 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
E2F5 | GFI1 | 16287849 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
E2F5 | PA2G4 | 21085677 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | E2F5 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
GATA2 | E2F5 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
SPI1 | E2F5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | E2F5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000016914 | E2F5 | 21454583 | rna interference,inhibition | experimental interaction detection | miRSponge |
URS00000EED18 | E2F5 | 19461653 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000016914 | E2F5 | 21454583 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
URS0000324096 | E2F5 | 17699775 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00000B59A2 | E2F5 | 16822819 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000237AF9 | E2F5 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00000451A1 | E2F5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00000600E6 | E2F5 | 22473208 23803041 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,clip | TarBase |
URS00002075FA | E2F5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000042E1F | E2F5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | E2F5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B3783 | E2F5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | E2F5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000031E12 | E2F5 | 25074381 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
URS0000122ED0 | E2F5 | 25416803 25422988 28232182 | mrna cleavage,inhibition | experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS000008931A | E2F5 | 25416803 27074041 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
URS00004CCDA3 | E2F5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000048F59D | E2F5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS00001F9A0F | E2F5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000006BE7D | E2F5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000075BDAA | E2F5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000024B619 | E2F5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
GMNN | E2F5 | 25348397 | N/A | physical interaction | ComPPI |
RB1 | E2F5 | 16360038 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
CREBBP | E2F5 | 10783242 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
EP300 | E2F5 | 12789259 14525934 25348397 7760804 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
SMAD3 | E2F5 | 12150994 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
KMT2D | E2F5 | 25348397 | N/A | physical interaction | ComPPI |
RBL2 | E2F5 | 11756542 14525934 17531812 24234451 25348397 | association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
XPO1 | E2F5 | 12089160 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
E2F5 | TFDP1 | 14525934 24234451 25348397 27705803 7760804 | association | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
E2F5 | RBL1 | 14525934 25348397 7892279 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
E2F5 | BRCC3 | 25348397 | N/A | physical interaction | ComPPI |
E2F5 | TFDP2 | 25348397 | N/A | physical interaction | ComPPI |
E2F5 | DNMT3L | 25348397 | N/A | physical interaction | ComPPI |
E2F5 | GGA1 | 25348397 | N/A | physical interaction | ComPPI |
E2F5 | LIN54 | 17531812 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
PRPF38A | E2F5 | 24234451 25348397 27173435 | association,physical association | physical interaction,tandem affinity purification,inference by socio-affinity scoring | ComPPI,IntAct |
RBL2 | E2F5 | 11756542 15838517 16600870 17531812 27898060 7760804 | stimulant | N/A | OmniPath |