Gene Information gene info

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GENE：NODAL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NODAL
FullNmae nodal growth differentiation factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7865
EnsembleID ENSG00000156574
Uniprot Q96S42

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NODAL apoptosis 22550067 Here, we show that Nodal activates ALK7 signaling and regulates beta-cell apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
NODAL GO:0000122,GO:0001831,GO:0001842,GO:0001889,GO:0001890,GO:0001892,GO:0001893,GO:0001944,GO:0001947,GO:0002085,GO:0005125,GO:0005515,GO:0005615,GO:0005615,GO:0007281,GO:0007420,GO:0008083,GO:0008283,GO:0009880,GO:0010085,GO:0010470,GO:0010575,GO:0010721,GO:0016015,GO:0022409,GO:0032927,GO:0033505,GO:0035019,GO:0035987,GO:0042074,GO:0043280,GO:0045766,GO:0045944,GO:0048327,GO:0048382,GO:0048546,GO:0048701,GO:0048859,GO:0050679,GO:0051091,GO:0060136,GO:0060137,GO:0060391,GO:0060395,GO:0060460,GO:0060766,GO:0060802,GO:0070374,GO:0070698,GO:0090009,GO:1900164,GO:1900224,GO:1901164,GO:1901383,GO:2000036

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NODAL hsa:4838 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
NODAL hsa:4838 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
NODAL hsa:4838 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NODAL ACVR2B 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CEBPA NODAL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NODAL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NODAL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NODAL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NODAL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NODAL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NANOG NODAL 23474366 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC NODAL 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000451A1 NODAL 22454525 23824327 25416803 mrna cleavage,inhibition western blot,clip,miRNA interference luciferase reporter assay TarBase
URS00001067D1 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000302909 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D6C3F NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E NODAL 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
KRT31 NODAL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RSPRY1 NODAL 25348397 N/A physical interaction ComPPI
NODAL ACVR2B 11952836 27898060 stimulant N/A OmniPath
TDGF1 NODAL 19874624 27898060 stimulant N/A OmniPath
NODAL ACVR1B 19874624 27898060 stimulant N/A OmniPath
NODAL ACVR1C 12606401 15531507 27898060 stimulant N/A OmniPath

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