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GENE：ROCK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ROCK2
FullNmae Rho associated coiled-coil containing protein kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10252
EnsembleID ENSG00000134318
Uniprot O75116

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ROCK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ROCK2 apoptosis 30747210 Furthermore, ROCK2 silencing enhanced SG formation and attenuated the level of apoptosis in the serum-free cell model. retulator signature

Go Annotation:

GeneSymbol Go id
ROCK2 GO:0000281,GO:0001837,GO:0001934,GO:0002931,GO:0003180,GO:0003723,GO:0004674,GO:0004674,GO:0004674,GO:0004674,GO:0005198,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005813,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006939,GO:0007249,GO:0007266,GO:0010595,GO:0010613,GO:0010628,GO:0010628,GO:0010629,GO:0010825,GO:0016525,GO:0018105,GO:0018105,GO:0018107,GO:0018107,GO:0018107,GO:0030036,GO:0030155,GO:0030335,GO:0030866,GO:0030866,GO:0030866,GO:0031032,GO:0031267,GO:0031644,GO:0032723,GO:0032956,GO:0035509,GO:0035509,GO:0036464,GO:0042752,GO:0043410,GO:0044788,GO:0045019,GO:0045019,GO:0045616,GO:0046872,GO:0048156,GO:0048511,GO:0048598,GO:0050321,GO:0051246,GO:0051298,GO:0051492,GO:0051496,GO:0051893,GO:0061157,GO:0070168,GO:0071394,GO:0071559,GO:0072518,GO:0072518,GO:0072518,GO:0072659,GO:0072659,GO:0090271,GO:0097746,GO:0106310,GO:0110061,GO:0150033,GO:1900037,GO:1901888,GO:1902004,GO:1902004,GO:1902961,GO:1902961,GO:1902966,GO:1902993,GO:1902993,GO:1903140,GO:1903140,GO:1903347,GO:1905145,GO:1905205,GO:1990776,GO:2000114,GO:2000145

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ROCK2 hsa:9475 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04360 Axon guidance - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04510 Focal adhesion - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04520 Adherens junction - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04530 Tight junction - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04611 Platelet activation - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05131 Shigellosis - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05132 Salmonella infection - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05135 Yersinia infection - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ROCK2 hsa:9475 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ROCK2 STAU1 16049941 23180781 physical association tandem affinity purification InnateDB
RHOA ROCK2 12727213 17673200 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ROCK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ROCK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ROCK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ROCK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ROCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E0AEA ROCK2 22473208 24743945 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000023BE29 ROCK2 24942287 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 ROCK2 24169343 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000012A1DD ROCK2 24169343 25416803 26903801 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004DA9DB ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 ROCK2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 ROCK2 21572407 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB ROCK2 21572407 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ROCK2 21572407 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 ROCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F ROCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000001A7A ROCK2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 ROCK2 25416803 25912304 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ROCK2 SLC9A1 22135298 phosphorylation N/A PhosphoSite
ROCK2 BACE1 22135298 phosphorylation N/A PhosphoSite
ROCK2 SORL1 22135298 phosphorylation N/A PhosphoSite
ROCK2 DPYSL2 22135298 phosphorylation N/A PhosphoSite
ROCK2 PPP1R14A 22135298 phosphorylation N/A PhosphoSite
ROCK2 SH3GL2 22135298 phosphorylation N/A PhosphoSite
ROCK2 LIMK2 22135298 phosphorylation N/A PhosphoSite
ROCK2 CNN3 22135298 phosphorylation N/A PhosphoSite
ROCK2 PPP1R14B 22135298 phosphorylation N/A PhosphoSite
ROCK2 EEF1A1 22135298 phosphorylation N/A PhosphoSite
ROCK2 PPP1R12A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PPP1R12A ROCK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 ROCK2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L ROCK2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
STK16 ROCK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LMNA ROCK2 25348397 N/A physical interaction ComPPI
ROCK1 ROCK2 25348397 N/A physical interaction ComPPI
RACGAP1 ROCK2 25348397 N/A physical interaction ComPPI
RHOA ROCK2 25348397 N/A physical interaction ComPPI
PPP1R12A ROCK2 10601309 11931630 12220642 12563012 12600888 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NTRK1 ROCK2 25348397 N/A physical interaction ComPPI
KSR2 ROCK2 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
NFKBIA ROCK2 12730857 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
RABGEF1 ROCK2 25348397 N/A physical interaction ComPPI
GPHN ROCK2 25348397 N/A physical interaction ComPPI
DNAJB11 ROCK2 25348397 N/A physical interaction ComPPI
ELAVL1 ROCK2 25348397 N/A physical interaction ComPPI
SNU13 ROCK2 25348397 N/A physical interaction ComPPI
ROCK2 MAGEC1 14525934 17137291 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ROCK2 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK2 WASHC5 25348397 N/A physical interaction ComPPI
ROCK2 KCTD7 25348397 N/A physical interaction ComPPI
ROCK2 WASHC2A 25348397 N/A physical interaction ComPPI
ROCK2 MTA2 25348397 N/A physical interaction ComPPI
ROCK2 ZW10 25348397 N/A physical interaction ComPPI
ROCK2 CDKN3 25348397 N/A physical interaction ComPPI
ROCK2 POLR1C 25348397 N/A physical interaction ComPPI
ROCK2 FBXO42 25348397 N/A physical interaction ComPPI
ROCK2 LRPAP1 25348397 N/A physical interaction ComPPI
ROCK2 ADD2 25348397 N/A physical interaction ComPPI
ROCK2 MYL2 25348397 N/A physical interaction ComPPI
ROCK2 LZTFL1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ROCK2 CYLD 25348397 N/A physical interaction ComPPI
ROCK2 STAU1 14525934 15121898 24234451 25348397 association experimental interaction detection,tandem affinity purification ComPPI,HPRD,IntAct
ROCK2 PPP1R14B 17022978 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
ROCK2 NCL 21281639 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ROCK2 FLOT2 22056876 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
ROCK2 LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ROCK2 PRKDC 24234451 26175416 association chromatin immunoprecipitation assay IntAct
H2BC21 ROCK2 24234451 30021884 physical association cross-linking study IntAct
HNRNPCL2 ROCK2 24234451 30021884 physical association cross-linking study IntAct
ROCK2 NPM1 17015463 27898060 N/A N/A OmniPath
SRC ROCK2 18559669 20826462 27898060 N/A N/A OmniPath
ROCK2 DPYSL2 10818093 21421798 22443207 27898060 stimulant N/A OmniPath
RHOA ROCK2 11350930 27898060 stimulant N/A OmniPath
ROCK2 PPP1R12A 10601309 11331307 11931630 12220642 12563012 12600888 27898060 inhibition N/A OmniPath
ROCK2 EEF1A1 17595531 24405853 27898060 N/A N/A OmniPath
ROCK2 VIM 12458200 14762106 18669648 19007248 27898060 N/A N/A OmniPath
ROCK2 LIMK1 10436159 10652353 27898060 stimulant N/A OmniPath
ROCK2 PPP1R14A 10869555 12144526 12495628 27898060 inhibition,stimulant N/A OmniPath
STAU1 ROCK2 15121898 16049941 27898060 N/A N/A OmniPath
ROCK2 IRF4 20697158 27898060 stimulant N/A OmniPath
ROCK2 MSN 19255442 27898060 stimulant N/A OmniPath
ROCK2 SLC9A1 25578862 27898060 stimulant N/A OmniPath
ROCK2 CAPZB 14517206 27898060 stimulant N/A OmniPath
ROCK2 SH3GL2 16164598 27898060 inhibition,stimulant N/A OmniPath
ARHGAP1 ROCK2 27898060 8772201 stimulant N/A OmniPath
ROCK2 ADD1 10209029 27898060 N/A N/A OmniPath
ROCK2 SORL1 20015111 21147781 27898060 N/A N/A OmniPath
ROCK2 PPP1R12C 11399775 17525332 27898060 N/A N/A OmniPath
ROCK2 CNN3 20861310 27898060 N/A N/A OmniPath

Visualization










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