Gene Information gene info

GENE:SEM1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SEM1
FullNmae SEM1 26S proteasome subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10845
EnsembleID ENSG00000127922
Uniprot P60896|Q6ZVN7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SEM1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SEM1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SEM1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SEM1 hsa:7979 path:hsa03050 Proteasome - Homo sapiens (human)
SEM1 hsa:7979 path:hsa03440 Homologous recombination - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05010 Alzheimer disease - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05012 Parkinson disease - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05016 Huntington disease - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05020 Prion disease - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
SEM1 hsa:7979 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
E2F4 SEM1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 SEM1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 SEM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
ETS1 SEM1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SEM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 SEM1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SEM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 SEM1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SEM1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 SEM1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000061E50F SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5659 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 SEM1 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NUDT21 SEM1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUDT21 SEM1 25348397 N/A physical interaction ComPPI
UBE2I SEM1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2I SEM1 25348397 N/A physical interaction ComPPI
HSPA8 SEM1 25348397 N/A physical interaction ComPPI
HSPA8 SEM1 25348397 N/A physical interaction ComPPI
BAG3 SEM1 25348397 N/A physical interaction ComPPI
BAG3 SEM1 25348397 N/A physical interaction ComPPI
UBA7 SEM1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBA7 SEM1 25348397 N/A physical interaction ComPPI
PSMC3 SEM1 25348397 N/A physical interaction ComPPI
PSMC3 SEM1 25348397 N/A physical interaction ComPPI
PSMC6 SEM1 25348397 N/A physical interaction ComPPI
PSMC6 SEM1 25348397 N/A physical interaction ComPPI
PSMD14 SEM1 25348397 N/A physical interaction ComPPI
PSMD14 SEM1 25348397 N/A physical interaction ComPPI
PSMD7 SEM1 25348397 N/A physical interaction ComPPI
PSMD7 SEM1 25348397 N/A physical interaction ComPPI
VCP SEM1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP SEM1 25348397 N/A physical interaction ComPPI
MAP1LC3B SEM1 25348397 N/A physical interaction ComPPI
SND1 SEM1 25348397 N/A physical interaction ComPPI
USP7 SEM1 25348397 N/A physical interaction ComPPI
PIAS1 SEM1 25348397 N/A physical interaction ComPPI
PSMD11 SEM1 25348397 N/A physical interaction ComPPI
UBC SEM1 25348397 N/A physical interaction ComPPI
BAG1 SEM1 25348397 N/A physical interaction ComPPI
BAG6 SEM1 25348397 N/A physical interaction ComPPI
SIN3A SEM1 25348397 N/A physical interaction ComPPI
RPA1 SEM1 25348397 N/A physical interaction ComPPI
FEN1 SEM1 25348397 N/A physical interaction ComPPI
PSMA6 SEM1 25348397 N/A physical interaction ComPPI
HNRNPU SEM1 25348397 N/A physical interaction ComPPI
EEF1A1 SEM1 25348397 N/A physical interaction ComPPI
UBR5 SEM1 25348397 N/A physical interaction ComPPI
PRRC2A SEM1 25348397 N/A physical interaction ComPPI
PSMD8 SEM1 25348397 N/A physical interaction ComPPI
PSMD1 SEM1 25348397 N/A physical interaction ComPPI
EIF3C SEM1 25348397 N/A physical interaction ComPPI
RAD51 SEM1 25348397 N/A physical interaction ComPPI
BRCA2 SEM1 25348397 N/A physical interaction ComPPI
PSMC5 SEM1 25348397 N/A physical interaction ComPPI
HUWE1 SEM1 25348397 N/A physical interaction ComPPI
UBQLN2 SEM1 25348397 N/A physical interaction ComPPI
RAD23A SEM1 25348397 N/A physical interaction ComPPI
SUMO2 SEM1 25348397 N/A physical interaction ComPPI
NEDD8 SEM1 25348397 N/A physical interaction ComPPI
CUL2 SEM1 25348397 N/A physical interaction ComPPI
CUL4B SEM1 25348397 N/A physical interaction ComPPI
YY1 SEM1 25348397 N/A physical interaction ComPPI
CUL1 SEM1 25348397 N/A physical interaction ComPPI
PSMC4 SEM1 25348397 N/A physical interaction ComPPI
PSMD2 SEM1 25348397 N/A physical interaction ComPPI
RAD23B SEM1 25348397 N/A physical interaction ComPPI
HECTD1 SEM1 25348397 N/A physical interaction ComPPI
PSMD10 SEM1 25348397 N/A physical interaction ComPPI
PSMD4 SEM1 25348397 N/A physical interaction ComPPI
TAF2 SEM1 25348397 N/A physical interaction ComPPI
SEM1 BRCA2 10373512 12228710 14525934 16205630 22293751 24013206 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
SEM1 PCID2 14525934 16189514 16239144 22343721 24234451 24515614 25348397 27898060 physical association two hybrid,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct,OmniPath
SEM1 MAP1LC3B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SEM1 PSMD1 25348397 N/A physical interaction ComPPI
SEM1 PSMD2 25348397 N/A physical interaction ComPPI
SEM1 PSMD3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SEM1 PSMD4 25348397 N/A physical interaction ComPPI
SEM1 PSMD8 25348397 N/A physical interaction ComPPI
SEM1 PSMD10 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSMD11 25348397 N/A physical interaction ComPPI
SEM1 PSMD12 25348397 N/A physical interaction ComPPI
SEM1 PSMD13 25348397 N/A physical interaction ComPPI
SEM1 PSMC1 25348397 N/A physical interaction ComPPI
SEM1 PSMC2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSMC5 25348397 N/A physical interaction ComPPI
SEM1 POLR2B 25348397 N/A physical interaction ComPPI
SEM1 INTS2 25348397 N/A physical interaction ComPPI
SEM1 INTS6 25348397 N/A physical interaction ComPPI
SEM1 RAD23A 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSMD6 25348397 N/A physical interaction ComPPI
SEM1 PSMA7 25348397 N/A physical interaction ComPPI
SEM1 PSMA6 25348397 N/A physical interaction ComPPI
SEM1 BRCA1 25348397 N/A physical interaction ComPPI
SEM1 PSMC4 25348397 N/A physical interaction ComPPI
SEM1 PIAS1 25348397 N/A physical interaction ComPPI
SEM1 TRIM33 25348397 N/A physical interaction ComPPI
SEM1 EIF3A 25348397 N/A physical interaction ComPPI
SEM1 EIF3C 25348397 N/A physical interaction ComPPI
SEM1 EEF1A1 25348397 N/A physical interaction ComPPI
SEM1 EEF1A2 25348397 N/A physical interaction ComPPI
SEM1 EEF1G 25348397 N/A physical interaction ComPPI
SEM1 EEF2 25348397 N/A physical interaction ComPPI
SEM1 DDX42 25348397 N/A physical interaction ComPPI
SEM1 RPF2 25348397 N/A physical interaction ComPPI
SEM1 TAF2 25348397 N/A physical interaction ComPPI
SEM1 YY1 25348397 N/A physical interaction ComPPI
SEM1 TOP1 25348397 N/A physical interaction ComPPI
SEM1 SIN3A 25348397 N/A physical interaction ComPPI
SEM1 SND1 25348397 N/A physical interaction ComPPI
SEM1 HNRNPU 25348397 N/A physical interaction ComPPI
SEM1 RBM15B 25348397 N/A physical interaction ComPPI
SEM1 ATXN2 25348397 N/A physical interaction ComPPI
SEM1 PRPF4B 25348397 N/A physical interaction ComPPI
SEM1 FEN1 25348397 N/A physical interaction ComPPI
SEM1 CKAP5 25348397 N/A physical interaction ComPPI
SEM1 TLN2 25348397 N/A physical interaction ComPPI
SEM1 TXNRD1 25348397 N/A physical interaction ComPPI
SEM1 UBE3A 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 RNF181 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 HUWE1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBR4 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PAAF1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSME1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSME2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSME3 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PSMF1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 ADRM1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction,blue native page ComPPI,IntAct
SEM1 USP14 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UCHL5 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 TXNL1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 USP15 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 USP7 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 RAD23B 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBQLN1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBQLN2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 CUL1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 CUL2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 CUL4B 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 FBXO7 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 HECTD1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 LTN1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 STUB1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBR1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBR5 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 SUMO2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 NEDD8 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBC 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 BAG1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 BAG2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 DDX39B 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PRRC2A 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 PRRC2C 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 BAG6 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UFD1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 NSFL1C 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 UBFD1 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 RPA1 25348397 N/A physical interaction ComPPI
SEM1 RAD51 25348397 N/A physical interaction ComPPI
PSME3 SEM1 25348397 N/A physical interaction ComPPI
PSME1 SEM1 25348397 N/A physical interaction ComPPI
PSME2 SEM1 25348397 N/A physical interaction ComPPI
UBQLN1 SEM1 25348397 N/A physical interaction ComPPI
PRPF4B SEM1 25348397 N/A physical interaction ComPPI
PSMC1 SEM1 25348397 N/A physical interaction ComPPI
NSFL1C SEM1 25348397 N/A physical interaction ComPPI
ATXN2 SEM1 25348397 N/A physical interaction ComPPI
TXNRD1 SEM1 25348397 N/A physical interaction ComPPI
BRCA1 SEM1 25348397 N/A physical interaction ComPPI
FBXO7 SEM1 25348397 N/A physical interaction ComPPI
STUB1 SEM1 25348397 N/A physical interaction ComPPI
PSMB4 SEM1 25348397 N/A physical interaction ComPPI
PSMB4 SEM1 25348397 N/A physical interaction ComPPI
CKAP5 SEM1 25348397 N/A physical interaction ComPPI
PSMB1 SEM1 25348397 N/A physical interaction ComPPI
PSMB1 SEM1 25348397 N/A physical interaction ComPPI
EIF3A SEM1 25348397 N/A physical interaction ComPPI
PSMA7 SEM1 25348397 N/A physical interaction ComPPI
EEF2 SEM1 25348397 N/A physical interaction ComPPI
EEF1G SEM1 25348397 N/A physical interaction ComPPI
TRIM33 SEM1 25348397 N/A physical interaction ComPPI
BAG2 SEM1 25348397 N/A physical interaction ComPPI
TOP1 SEM1 25348397 N/A physical interaction ComPPI
TLN2 SEM1 25348397 N/A physical interaction ComPPI
UFD1 SEM1 25348397 N/A physical interaction ComPPI
UCHL5 SEM1 25348397 N/A physical interaction ComPPI
POLR2B SEM1 25348397 N/A physical interaction ComPPI
EEF1A2 SEM1 25348397 N/A physical interaction ComPPI
ADRM1 SEM1 25348397 N/A physical interaction ComPPI
PSMD13 SEM1 25348397 N/A physical interaction ComPPI
PSMD12 SEM1 25348397 N/A physical interaction ComPPI
UBR1 SEM1 25348397 N/A physical interaction ComPPI
DDX39B SEM1 25348397 N/A physical interaction ComPPI
PSMF1 SEM1 25348397 N/A physical interaction ComPPI
PCID2 SEM1 25348397 N/A physical interaction ComPPI
PSMC2 SEM1 25348397 N/A physical interaction ComPPI
PSMD6 SEM1 25348397 N/A physical interaction ComPPI
TXNL1 SEM1 25348397 N/A physical interaction ComPPI
DDX42 SEM1 25348397 N/A physical interaction ComPPI
PAAF1 SEM1 25348397 N/A physical interaction ComPPI
UBR4 SEM1 25348397 N/A physical interaction ComPPI
UBE3A SEM1 25348397 N/A physical interaction ComPPI
SEM1 PSMD3 25348397 N/A physical interaction ComPPI
SEM1 INTS2 25348397 N/A physical interaction ComPPI
SEM1 INTS6 25348397 N/A physical interaction ComPPI
SEM1 RPF2 25348397 N/A physical interaction ComPPI
SEM1 RBM15B 25348397 N/A physical interaction ComPPI
SEM1 RNF181 25348397 N/A physical interaction ComPPI
SEM1 USP14 25348397 N/A physical interaction ComPPI
SEM1 USP15 25348397 N/A physical interaction ComPPI
SEM1 LTN1 25348397 N/A physical interaction ComPPI
SEM1 PRRC2C 25348397 N/A physical interaction ComPPI
SEM1 UBFD1 25348397 N/A physical interaction ComPPI
SEM1 BRCA2 10373512 12228710 16205630 16239144 17145710 17563742 22293751 26145171 27898060 stimulant N/A OmniPath

Visualization