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GENE：SUFU

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SUFU
FullNmae SUFU negative regulator of hedgehog signaling
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16466
EnsembleID ENSG00000107882
Uniprot Q9UMX1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SUFU apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SUFU GO:0000122,GO:0001843,GO:0001947,GO:0003281,GO:0003714,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005737,GO:0005737,GO:0005829,GO:0006355,GO:0007165,GO:0007286,GO:0008013,GO:0008134,GO:0019901,GO:0021775,GO:0021776,GO:0035904,GO:0042308,GO:0042994,GO:0043433,GO:0043588,GO:0045668,GO:0045879,GO:0045879,GO:0060831,GO:0060976,GO:0097542,GO:0097546,GO:1901621,GO:1990788,GO:1990788,GO:2000059,GO:2001040

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SUFU hsa:51684 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
SUFU hsa:51684 path:hsa05200 Pathways in cancer - Homo sapiens (human)
SUFU hsa:51684 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUFU ULK3 0643644 11001584 16371461 16611981 16651270 17845852 18455992 18497536 18813803 19055941 19549984 19592253 19666503 19684112 19878745 19906571 20643644 20956384 21209912 26192618 interaction type N/A ACSN
GLI1 SUFU 10559945 11001584 11960000 17638910 18754008 19055941 19081070 19684112 22354771 23031257 26192618 interaction type N/A ACSN
SMO SUFU 17641202 17688959 18820483 18997815 19081070 19549984 19592253 20016067 20215540 20643644 20956384 21209912 23031257 26192618 interaction type N/A ACSN
KIF3A SUFU 11208056 14603322 20643644 20956384 26192618 interaction type N/A ACSN
KIF3B SUFU 11208056 14603322 20643644 20956384 26192618 interaction type N/A ACSN
CDC34 SUFU 16371461 16611981 16651270 17329932 18813803 26192618 9367342 interaction type N/A ACSN
CUL1 SUFU 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16611981 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258 26192618 interaction type N/A ACSN
RBX1 SUFU 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16611981 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258 26192618 interaction type N/A ACSN
SKP1 SUFU 11900249 12648680 12820959 15071497 15340381 15459660 15688063 15703371 16611981 16697054 17884153 18931676 19150432 19270156 19622404 19686080 19809470 19847258 26192618 interaction type N/A ACSN
RCN3 SUFU 16189514 23180781 physical association pull down InnateDB
SUFU PEX26 16189514 23180781 physical association pull down InnateDB
SUFU SUFU 10564661 26467481 bind,up-regulates,down-regulates,relocalization reaction N/A Signor
SUFU STK36 10072378 23331499 stimulation N/A SignaLink,SignaLink
SUFU GLI1 10559945 10564661 12426310 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
SUFU GLI3 10564661 23331499 stimulation N/A SignaLink,SignaLink
SUFU GLIS2 15367681 23331499 stimulation N/A SignaLink,SignaLink
RAB23 SUFU 22365972 interaction type,stimulation N/A SignaLink
PRKACA SUFU 14611647 21317289 23331499 phosphorylation reaction,stimulation N/A SignaLink,SignaLink
GSK3B SUFU 21317289 phosphorylation reaction,stimulation N/A SignaLink
SUFU SAP18 11960000 14611647 23331499 stimulation N/A SignaLink
MTSS1 SUFU 15545630 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SUFU PIAS1 20005715 interaction type N/A PSP
SUFU NCOA3 20005715 interaction type N/A PSP
SUFU NCOA3 14611647 18988627 20005715 N/A N/A SignaLink
SUFU PIAS1 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
PRDM14 SUFU 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SUFU 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000451A1 SUFU 18077375 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000451A1 SUFU 18077375 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 SUFU 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000160683 SUFU 25416803 26462018 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000DD591 SUFU 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000209F04 SUFU 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA SUFU 22135298 phosphorylation N/A PhosphoSite
GSK3B SUFU 22135298 phosphorylation N/A PhosphoSite
IHH SUFU 25361965 interaction type N/A PTMCode2
SUFU IHH 25361965 interaction type N/A PTMCode2
GLI1 SUFU 25361965 interaction type N/A PTMCode2
SUFU GLI1 25361965 interaction type N/A PTMCode2
SHH SUFU 25361965 interaction type N/A PTMCode2
SUFU SHH 25361965 interaction type N/A PTMCode2
DHH SUFU 25361965 interaction type N/A PTMCode2
SUFU DHH 25361965 interaction type N/A PTMCode2
HNRNPA1 SUFU 25361965 interaction type N/A PTMCode2
SUFU HNRNPA1 25361965 interaction type N/A PTMCode2
GLI2 SUFU 25361965 interaction type N/A PTMCode2
SUFU GLI2 25361965 interaction type N/A PTMCode2
SUFU BTRC 25361965 interaction type N/A PTMCode2
BTRC SUFU 25361965 interaction type N/A PTMCode2
SUFU NCOA3 25361965 interaction type N/A PTMCode2
NCOA3 SUFU 25361965 interaction type N/A PTMCode2
SUFU PTCH2 25361965 interaction type N/A PTMCode2
PTCH2 SUFU 25361965 interaction type N/A PTMCode2
SUFU SAP18 25361965 interaction type N/A PTMCode2
SAP18 SUFU 25361965 interaction type N/A PTMCode2
SUFU GLI3 25361965 interaction type N/A PTMCode2
GLI3 SUFU 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LGALS3 SUFU 14525934 14611647 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
FAM90A1 SUFU 25348397 N/A physical interaction ComPPI
SAP18 SUFU 11960000 14525934 14611647 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
CRX SUFU 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BFSP2 SUFU 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCA5 SUFU 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
QPRT SUFU 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ZNF219 SUFU 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
EGLN3 SUFU 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SUFU GLI1 10559945 12426310 14525934 22439934 24217340 24234451 24311597 25241761 25348397 25609649 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,x-ray crystallography,physical interaction,two hybrid array,fluorescence microscopy,in vitro,in vivo,tandem affinity purification,proximity ligation assay,x ray scattering,two hybrid prey pooling approach,thermal shift binding,microscale thermophoresis ComPPI,HPRD,IntAct
SUFU GLI2 10564661 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SUFU GLI3 10564661 14525934 24234451 24311597 25348397 N/A experimental interaction detection,pull down,x-ray crystallography,physical interaction,in vitro,mass spectrometry study of hydrogen/deuterium exchange ComPPI,HPRD,IntAct
SUFU HMGA1 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU NCOA3 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU LAMTOR3 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU BTRC 10564661 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SUFU RNF19A 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU STK36 10806483 14525934 24234451 25241761 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SUFU PIAS1 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU SETDB1 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU ZNF446 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SUFU ZNF764 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach ComPPI,IntAct
SUFU PEX26 14525934 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid pooling approach,two hybrid ComPPI,HPRD,IntAct
SUFU GLIS3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SUFU RBPJ 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU HNRNPA1 14525934 14611647 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SUFU ZNF747 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SUFU HDX 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU FBXL17 25348397 N/A physical interaction ComPPI
SUFU NXPH3 25348397 N/A physical interaction ComPPI
SUFU NFATC3 25348397 N/A physical interaction ComPPI
SUFU LIPT1 25348397 N/A physical interaction ComPPI
SUFU NR2E1 25348397 N/A physical interaction ComPPI
SUFU TTLL3 25348397 N/A physical interaction ComPPI
SUFU ALDH1B1 25348397 N/A physical interaction ComPPI
SUFU ZBTB46 25348397 N/A physical interaction ComPPI
SUFU LDLRAD4 25348397 N/A physical interaction ComPPI
SUFU EDEM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUFU CDC25C 25348397 N/A physical interaction ComPPI
SUFU ZNF785 25348397 N/A physical interaction ComPPI
SUFU ZFC3H1 25348397 N/A physical interaction ComPPI
SUFU UBE3D 25348397 N/A physical interaction ComPPI
SUFU LRRC36 25348397 N/A physical interaction ComPPI
SUFU LOXL3 25348397 N/A physical interaction ComPPI
SUFU OVOL1 25348397 N/A physical interaction ComPPI
SUFU PEX11A 25348397 N/A physical interaction ComPPI
SUFU PRPF31 25348397 N/A physical interaction ComPPI
SUFU PCK2 25348397 N/A physical interaction ComPPI
SUFU BMP4 25348397 N/A physical interaction ComPPI
SUFU ABI3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU SLC41A3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU CRTC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU ZNF763 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU ZNF114 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU ZIC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU KRT75 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU ZNF330 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU MAGEL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU LZTS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU ZSCAN18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU KRT27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ZNF263 SUFU 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RCN3 SUFU 14525934 16189514 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
MID1IP1 SUFU 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
STX19 SUFU 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SUFU SUFU 10564661 14525934 14611647 24234451 N/A pull down,two hybrid HPRD,IntAct
PRKACA SUFU 14611647 21317289 23337587 27898060 stimulant N/A OmniPath
SUFU GLI2 10531011 10564661 15367681 20463034 27898060 inhibition N/A OmniPath
SMO SUFU 22114142 27898060 inhibition,stimulant N/A OmniPath
SUFU GLI1 10531011 10559945 10564661 11960000 12426310 14611647 16189514 16316410 19055941 21076395 21543335 22439934 24217340 24311597 25241761 25609649 26120032 27898060 inhibition,stimulant N/A OmniPath
SUFU GLI3 10531011 10564661 17145710 20463034 24311597 27898060 inhibition,stimulant N/A OmniPath
GSK3B SUFU 21317289 27898060 N/A N/A OmniPath
FBXW11 SUFU 10564661 27898060 stimulant N/A OmniPath
SUFU SAP18 1196 11960000 14611647 27898060 stimulant N/A OmniPath
SUFU GLIS3 16189514 21543335 26147758 27898060 inhibition N/A OmniPath
SUFU GLIS2 16316410 27898060 inhibition N/A OmniPath
MTSS1 SUFU 15545630 27898060 stimulant N/A OmniPath

Visualization










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