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GENE：TFAP2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TFAP2A
FullNmae transcription factor AP-2 alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11742
EnsembleID ENSG00000137203
Uniprot P05549

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TFAP2A mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TFAP2A apoptosis 37083077 In vitro experiments revealed that the knockdown of TFAP2A inhibited the proliferation and migration of cervical cancer cells and promoted apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
TFAP2A GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001227,GO:0001228,GO:0001822,GO:0003404,GO:0003409,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006357,GO:0007605,GO:0008285,GO:0010628,GO:0010842,GO:0010944,GO:0021559,GO:0021623,GO:0030501,GO:0035115,GO:0042127,GO:0042472,GO:0042802,GO:0043066,GO:0043525,GO:0043565,GO:0043565,GO:0045595,GO:0045892,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0048701,GO:0048856,GO:0060021,GO:0060349,GO:0061029,GO:0070172,GO:0071281,GO:0140536,GO:1990837,GO:2000378

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BCL2 TFAP2A 12391156 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
CDH1 TFAP2A 12391156 23180781 physical association anti tag coimmunoprecipitation InnateDB
TFAP2A IRF6 18836445 23180781 physical association anti tag coimmunoprecipitation InnateDB
TFAP2A CTNNAL1 22359570 23180781 physical association electrophoretic mobility supershift assay InnateDB
TFAP2A BRS3 17355223 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 TFAP2A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 TFAP2A 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TFAP2A 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 TFAP2A 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 TFAP2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TFAP2A 12843180 trascriptional regulation,stimulation inferred by curator TFlink
KLF12 TFAP2A 10704285 11373277 trascriptional regulation,stimulation inferred by curator TFlink
NR2F2 TFAP2A 20195529 trascriptional regulation,stimulation inferred by curator TFlink
YY1 TFAP2A 18218085 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TFAP2A N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 TFAP2A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS0000122ED0 TFAP2A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00003CF1AD TFAP2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004F24A9 TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004B83FE TFAP2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 TFAP2A 20371350 21572407 23446348 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000209F04 TFAP2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 TFAP2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C3AC1 TFAP2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 TFAP2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 TFAP2A 20371350 21572407 23446348 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007D64A TFAP2A 20371350 21572407 23446348 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000F0F49 TFAP2A 20371350 21572407 23446348 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000040EE1D TFAP2A 20371350 21572407 23446348 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000041CB9C TFAP2A 20371350 21572407 23446348 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000171CD1 TFAP2A 20371350 21572407 23446348 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000027080C TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000024DFCE TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000610EFA TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000045E0EC TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 TFAP2A 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002F3336 TFAP2A 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 TFAP2A 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000157FBE TFAP2A 19536157 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 TFAP2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 TFAP2A 25416803 27698912 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000246356 TFAP2A 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 TFAP2A 22135298 phosphorylation N/A PhosphoSite
PRKAA2 TFAP2A 22135298 phosphorylation N/A PhosphoSite
PRKACA TFAP2A 22135298 phosphorylation N/A PhosphoSite
PRKD1 TFAP2A 22135298 phosphorylation N/A PhosphoSite
HIP1 TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A HIP1 25361965 interaction type N/A PTMCode2
MYC TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A MYC 25361965 interaction type N/A PTMCode2
LDLRAP1 TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A LDLRAP1 25361965 interaction type N/A PTMCode2
CASP6 TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A CASP6 25361965 interaction type N/A PTMCode2
CLTC TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A CLTC 25361965 interaction type N/A PTMCode2
TFAP2A TP53 25361965 interaction type N/A PTMCode2
TP53 TFAP2A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I TFAP2A 12072434 24234451 24835590 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
KCTD1 TFAP2A 19115315 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKAA2 TFAP2A 25348397 N/A physical interaction ComPPI
BAG3 TFAP2A 25348397 N/A physical interaction ComPPI
NPM1 TFAP2A 14525934 17318229 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
FOXB1 TFAP2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
MKRN3 TFAP2A 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AIM2 TFAP2A 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
LDLRAP1 TFAP2A 12221107 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DAB2 TFAP2A 25348397 N/A physical interaction ComPPI
ERBB4 TFAP2A 25348397 N/A physical interaction ComPPI
SP1 TFAP2A 15705965 19074833 22182699 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CASP3 TFAP2A 11438643 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRB2 TFAP2A 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN TFAP2A 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
RB1 TFAP2A 14525934 25348397 27898060 9632747 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
AR TFAP2A 25348397 N/A physical interaction ComPPI
EP300 TFAP2A 12586840 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
PRKD1 TFAP2A 25348397 N/A physical interaction ComPPI
WWP1 TFAP2A 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
APC TFAP2A 14525934 15331612 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DEK TFAP2A 12595566 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TFAP2A CASP1 11438643 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TFAP2A YBX1 11973333 14525934 25348397 27898060 9830047 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TFAP2A CASP6 11438643 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TFAP2A WWP2 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
TFAP2A MAGI1 14525934 25348397 9169421 N/A experimental interaction detection,in vitro ComPPI,HPRD
TFAP2A CITED2 11694877 11744733 12586840 14525934 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,far western blotting,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
TFAP2A CITED4 11744733 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TFAP2A EPN2 10567358 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TFAP2A SYT1 14525934 25348397 8087843 N/A experimental interaction detection,in vitro ComPPI,HPRD
TFAP2A HIP1 11604514 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TFAP2A CLTC 14525934 1587861 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TFAP2A CTNNB1 14525934 15331612 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TFAP2A SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TFAP2A TP53 12226108 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
TFAP2A MYC 25348397 N/A physical interaction ComPPI
TFAP2A YY1 15870067 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TFAP2A PPARG 25348397 N/A physical interaction ComPPI
TFAP2A ELAVL1 25348397 N/A physical interaction ComPPI
TFAP2A DNMT3A 25348397 N/A physical interaction ComPPI
TFAP2A BRCA1 25348397 N/A physical interaction ComPPI
TFAP2A AURKA 25348397 N/A physical interaction ComPPI
TFAP2A EPN1 25348397 N/A physical interaction ComPPI
TFAP2A SH3BP4 16325581 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TFAP2A EPS15 18524853 25348397 27898060 9490719 N/A physical interaction ComPPI,OmniPath
TFAP2A SRA1 25348397 N/A physical interaction ComPPI
TFAP2A EPAS1 25348397 N/A physical interaction ComPPI
TFAP2A HECW2 25348397 N/A physical interaction ComPPI
TFAP2A KCTD15 25348397 N/A physical interaction ComPPI
TFAP2A GSTO2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFAP2A TFAP2D 25348397 N/A physical interaction ComPPI
TFAP2A ACOT1 25348397 N/A physical interaction ComPPI
TFAP2A EEFSEC 25348397 N/A physical interaction ComPPI
TFAP2A EWSR1 25348397 N/A physical interaction ComPPI
TFAP2A EED 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFAP2A AP4E1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFAP2A MAX 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
TFAP2A FOXE1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TFAP2A CSNK2B 25348397 N/A physical interaction ComPPI
TFAP2A CSNK2A1 25348397 N/A physical interaction ComPPI
TFAP2A TFAP2C 25348397 N/A physical interaction ComPPI
TFAP2A CFTR 25348397 N/A physical interaction ComPPI
TFAP2A XRCC6 25348397 N/A physical interaction ComPPI
TFAP2A XRCC5 25348397 N/A physical interaction ComPPI
TFAP2A RELA 25348397 N/A physical interaction ComPPI
TFAP2A NFKB1 25348397 N/A physical interaction ComPPI
TFAP2A TFAP2B 25348397 N/A physical interaction ComPPI
TFAP2A AP2B1 25348397 N/A physical interaction ComPPI
TFAP2A AP1M2 25348397 N/A physical interaction ComPPI
TFAP2A EYA2 25348397 N/A physical interaction ComPPI
TFAP2A NR3C1 25348397 N/A physical interaction ComPPI
TFAP2A PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
FREM2 TFAP2A 24234451 24835590 association chromatin immunoprecipitation assay IntAct
FOXA1 TFAP2A 24234451 24835590 association chromatin immunoprecipitation assay IntAct
TFAP2A RNF20 24374663 27898060 N/A N/A OmniPath
PRKACA TFAP2A 10037142 27898060 stimulant N/A OmniPath
PRKD1 TFAP2A 18845787 27898060 N/A N/A OmniPath
CSNK2A1 TFAP2A 21777522 27898060 stimulant N/A OmniPath

Visualization










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