Gene Information gene info

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GENE：TOP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TOP1
FullNmae DNA topoisomerase I
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11986
EnsembleID ENSG00000198900
Uniprot P11387

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TOP1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TOP1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TOP1 GO:0000228,GO:0000932,GO:0000978,GO:0001650,GO:0001673,GO:0003677,GO:0003677,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0003723,GO:0003917,GO:0003917,GO:0003917,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005654,GO:0005730,GO:0005730,GO:0005730,GO:0006260,GO:0006265,GO:0006265,GO:0006265,GO:0006338,GO:0007059,GO:0007623,GO:0008301,GO:0009410,GO:0012501,GO:0016310,GO:0018105,GO:0019904,GO:0032922,GO:0032993,GO:0040016,GO:0043204,GO:0097100

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HNRNPA1 TOP1 17481653 23180781 physical association two hybrid InnateDB
TOP1 NONO 17481653 23180781 physical association two hybrid InnateDB
SRSF1 TOP1 17481653 23180781 physical association two hybrid InnateDB
OAS3 TOP1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF2AK2 TOP1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDK2 TOP1 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
EED TOP1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TOP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 TOP1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 TOP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TOP1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC TOP1 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 TOP1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 TOP1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TOP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB TOP1 8524227 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 TOP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 TOP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TOP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TOP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 TOP1 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A TOP1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 TOP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 TOP1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 TOP1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005651EE TOP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 TOP1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000285DCB TOP1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC864 TOP1 23158364 24103454 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 TOP1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CDK1 TOP1 22135298 phosphorylation N/A PhosphoSite
ABL1 TOP1 22135298 phosphorylation N/A PhosphoSite
PRKCA TOP1 22135298 phosphorylation N/A PhosphoSite
NONO TOP1 25361965 interaction type N/A PTMCode2
TOP1 NONO 25361965 interaction type N/A PTMCode2
TOP1 CSNK2A1 25361965 interaction type N/A PTMCode2
TOPBP1 TOP1 25361965 interaction type N/A PTMCode2
TOP1 TOPBP1 25361965 interaction type N/A PTMCode2
CASP6 TOP1 25361965 interaction type N/A PTMCode2
TOP1 CASP6 25361965 interaction type N/A PTMCode2
CSNK2A2 TOP1 25361965 interaction type N/A PTMCode2
TOP1 CSNK2A2 25361965 interaction type N/A PTMCode2
TP53 TOP1 25361965 interaction type N/A PTMCode2
TOP1 TP53 25361965 interaction type N/A PTMCode2
CASP3 TOP1 25361965 interaction type N/A PTMCode2
TOP1 CASP3 25361965 interaction type N/A PTMCode2
RAD52 TOP1 25361965 interaction type N/A PTMCode2
TOP1 RAD52 25361965 interaction type N/A PTMCode2
NCL TOP1 25361965 interaction type N/A PTMCode2
TOP1 NCL 25361965 interaction type N/A PTMCode2
BTBD1 TOP1 25361965 interaction type N/A PTMCode2
TOP1 BTBD1 25361965 interaction type N/A PTMCode2
BTBD2 TOP1 25361965 interaction type N/A PTMCode2
TOP1 BTBD2 25361965 interaction type N/A PTMCode2
NPM1 TOP1 25361965 interaction type N/A PTMCode2
TOP1 NPM1 25361965 interaction type N/A PTMCode2
MGMT TOP1 25361965 interaction type N/A PTMCode2
TOP1 MGMT 25361965 interaction type N/A PTMCode2
TDP1 TOP1 25361965 interaction type N/A PTMCode2
TOP1 TDP1 25361965 interaction type N/A PTMCode2
SFPQ TOP1 25361965 interaction type N/A PTMCode2
TOP1 SFPQ 25361965 interaction type N/A PTMCode2
TOPORS TOP1 25361965 interaction type N/A PTMCode2
TOP1 TOPORS 25361965 interaction type N/A PTMCode2
TOP1 EXOSC10 25361965 interaction type N/A PTMCode2
EXOSC10 TOP1 25361965 interaction type N/A PTMCode2
TOP1 NKX3-1 25361965 interaction type N/A PTMCode2
NKX3-1 TOP1 25361965 interaction type N/A PTMCode2
TOP1 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 TOP1 25361965 interaction type N/A PTMCode2
TOP1 TOP2B 25361965 interaction type N/A PTMCode2
TOP2B TOP1 25361965 interaction type N/A PTMCode2
TOP1 TOP2A 25361965 interaction type N/A PTMCode2
TOP2A TOP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
UBE2I TOP1 10759568 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SNW1 TOP1 25348397 N/A physical interaction ComPPI
CDC5L TOP1 25348397 N/A physical interaction ComPPI
HNRNPC TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
DDX21 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NPM1 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SNRPA1 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PCNA TOP1 25348397 N/A physical interaction ComPPI
TP53BP1 TOP1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SNRPG TOP1 25348397 N/A physical interaction ComPPI
SNRPD1 TOP1 25348397 N/A physical interaction ComPPI
VCP TOP1 25348397 N/A physical interaction ComPPI
LMNA TOP1 25348397 N/A physical interaction ComPPI
MCM5 TOP1 25348397 N/A physical interaction ComPPI
GABARAPL2 TOP1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TRIM32 TOP1 25348397 N/A physical interaction ComPPI
KEAP1 TOP1 25348397 N/A physical interaction ComPPI
DDX17 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
APLF TOP1 17396150 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
NF2 TOP1 25348397 N/A physical interaction ComPPI
SNRNP70 TOP1 25348397 N/A physical interaction ComPPI
CASP3 TOP1 14525934 25348397 9933635 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKDC TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
JUN TOP1 14525934 15923621 24234451 25348397 25609649 27898060 association anti bait coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SMAD2 TOP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SUMO1 TOP1 11709553 12149243 12439742 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
DHX9 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
COPS5 TOP1 25348397 N/A physical interaction ComPPI
RBM39 TOP1 25348397 N/A physical interaction ComPPI
SF3B1 TOP1 12549820 15848144 24234451 25348397 27898060 association pull down,physical interaction ComPPI,IntAct,OmniPath
NONO TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
IRF8 TOP1 25348397 N/A physical interaction ComPPI
IRF4 TOP1 25348397 N/A physical interaction ComPPI
SFPQ TOP1 14525934 15848144 24234451 25348397 9756848 association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
LIG4 TOP1 25348397 N/A physical interaction ComPPI
U2AF2 TOP1 25348397 N/A physical interaction ComPPI
CUL3 TOP1 25348397 N/A physical interaction ComPPI
CDKN2A TOP1 25348397 N/A physical interaction ComPPI
NTRK1 TOP1 25348397 N/A physical interaction ComPPI
JAK1 TOP1 25348397 N/A physical interaction ComPPI
EIF2AK2 TOP1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP6 TOP1 14525934 25348397 9933635 N/A experimental interaction detection,in vitro ComPPI,HPRD
PARP1 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
BUB3 TOP1 25348397 N/A physical interaction ComPPI
NCOA6 TOP1 12519782 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
XRCC5 TOP1 21679440 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
RBM14 TOP1 25348397 N/A physical interaction ComPPI
RBL2 TOP1 25348397 N/A physical interaction ComPPI
TARBP2 TOP1 25348397 N/A physical interaction ComPPI
MYC TOP1 17314511 20195357 24234451 25348397 association,physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
HNRNPU TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
CSNK2A1 TOP1 14525934 25348397 2998765 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PYGM TOP1 25348397 N/A physical interaction ComPPI
HNRNPL TOP1 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TPR TOP1 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
DDX5 TOP1 15848144 24234451 25348397 association pull down ComPPI,IntAct
PA2G4 TOP1 15064750 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKI67 TOP1 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
VDAC1 TOP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PDHA1 TOP1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATM TOP1 25348397 N/A physical interaction ComPPI
RCVRN TOP1 25348397 N/A physical interaction ComPPI
TAL1 TOP1 25348397 N/A physical interaction ComPPI
TOPORS TOP1 10352183 14525934 17976381 20805487 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
HNRNPA2B1 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SRSF1 TOP1 12270705 14525934 15848144 17481653 20805487 24234451 25348397 27898060 8639538 9611241 association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
ZRANB2 TOP1 25348397 N/A physical interaction ComPPI
CSNK2A2 TOP1 25348397 N/A physical interaction ComPPI
MDM2 TOP1 25348397 N/A physical interaction ComPPI
CDK2 TOP1 25348397 N/A physical interaction ComPPI
CUL1 TOP1 25348397 N/A physical interaction ComPPI
EGFR TOP1 24234451 24780295 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF2 TOP1 25348397 N/A physical interaction ComPPI
GTF2E2 TOP1 25348397 N/A physical interaction ComPPI
SUPT16H TOP1 25348397 N/A physical interaction ComPPI
NCSTN TOP1 25348397 N/A physical interaction ComPPI
GABARAP TOP1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MDC1 TOP1 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
SRSF11 TOP1 14525934 25348397 9756848 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
VCAM1 TOP1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 TOP1 25348397 N/A physical interaction ComPPI
EED TOP1 25348397 N/A physical interaction ComPPI
CDK8 TOP1 25348397 N/A physical interaction ComPPI
CUL7 TOP1 25348397 N/A physical interaction ComPPI
NR3C1 TOP1 25348397 N/A physical interaction ComPPI
H3C1 TOP1 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HDAC5 TOP1 25348397 N/A physical interaction ComPPI
CAND1 TOP1 25348397 N/A physical interaction ComPPI
APAF1 TOP1 25348397 N/A physical interaction ComPPI
BARD1 TOP1 25348397 N/A physical interaction ComPPI
HDAC9 TOP1 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEM1 TOP1 25348397 N/A physical interaction ComPPI
H3-3A TOP1 25348397 N/A physical interaction ComPPI
FSHR TOP1 14525934 15196694 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ELK3 TOP1 25348397 N/A physical interaction ComPPI
EAF1 TOP1 25348397 N/A physical interaction ComPPI
HNRNPR TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
LSM4 TOP1 25348397 N/A physical interaction ComPPI
SYMPK TOP1 25348397 N/A physical interaction ComPPI
TRIM25 TOP1 25348397 N/A physical interaction ComPPI
NKX3-1 TOP1 17234752 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down,physical interaction,confocal microscopy,tandem affinity purification ComPPI,IntAct,OmniPath
PDE10A TOP1 25348397 N/A physical interaction ComPPI
ELAVL1 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
NOP56 TOP1 25348397 N/A physical interaction ComPPI
DDB2 TOP1 25348397 N/A physical interaction ComPPI
SRPK2 TOP1 25348397 N/A physical interaction ComPPI
LAMB3 TOP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ESR1 TOP1 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
CDT1 TOP1 25348397 N/A physical interaction ComPPI
SNRNP200 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
CKAP5 TOP1 25348397 N/A physical interaction ComPPI
H1-2 TOP1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
EFTUD2 TOP1 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
RBL1 TOP1 25348397 N/A physical interaction ComPPI
HNRNPM TOP1 25348397 N/A physical interaction ComPPI
TOP1 BTBD1 11818025 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TOP1 BTBD2 11818025 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TOP1 TP53 10468612 11805286 14525934 18697815 25348397 27898060 8639538 N/A experimental interaction detection,physical interaction ComPPI,HPRD,OmniPath
TOP1 NCL 10967121 14525934 15848144 24234451 25348397 27898060 8567649 9512561 association experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct,OmniPath
TOP1 CDKN2A 25348397 N/A physical interaction ComPPI
TOP1 RRP1B 25348397 N/A physical interaction,tandem affinity purification ComPPI
TOP1 MACROH2A1 25348397 N/A physical interaction ComPPI
TOP1 PMS1 25348397 N/A physical interaction ComPPI
TOP1 MGMT 25348397 N/A physical interaction ComPPI
TOP1 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP1 FBL 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 H1-10 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 HNRNPA1 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TOP1 HNRNPA3 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 NAT10 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 NOP2 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 SF3B3 25348397 N/A physical interaction ComPPI
TOP1 TCOF1 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 DDX23 15848144 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TOP1 PRPF8 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TOP1 OAS3 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP1 HDGF 21907836 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOP1 SIRT7 25348397 N/A physical interaction ComPPI
TOP1 GTF3C1 25348397 N/A physical interaction ComPPI
TOP1 ERCC8 25348397 N/A physical interaction ComPPI
TOP1 KMT2A 25348397 N/A physical interaction ComPPI
TOP1 IRF9 25348397 N/A physical interaction ComPPI
TOP1 GEMIN4 25348397 N/A physical interaction ComPPI
TOP1 GRWD1 25348397 N/A physical interaction ComPPI
TOP1 PPP2R2B 25348397 N/A physical interaction ComPPI
TOP1 TUBD1 25348397 N/A physical interaction ComPPI
TOP1 APP 25348397 N/A physical interaction ComPPI
TOP1 SF3B6 25348397 N/A physical interaction ComPPI
TOP1 UTP20 25348397 N/A physical interaction ComPPI
TOP1 S100A9 25348397 N/A physical interaction ComPPI
TOP1 IL7R 25348397 N/A physical interaction ComPPI
TOP1 CDK14 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TOP1 TARDBP 25348397 N/A physical interaction ComPPI
TOP1 SEM1 25348397 N/A physical interaction ComPPI
TOP1 ERG 25348397 N/A physical interaction ComPPI
TOP1 OBSL1 25348397 N/A physical interaction ComPPI
TOP1 RBM25 25348397 N/A physical interaction ComPPI
TOP1 PWP1 25348397 N/A physical interaction ComPPI
TOP1 RBM28 25348397 N/A physical interaction ComPPI
TOP1 TOP2A 15848144 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TOP1 TOP2B 25348397 N/A physical interaction ComPPI
TOP1 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP1 PES1 25348397 N/A physical interaction ComPPI
TOP1 POU5F1 25348397 N/A physical interaction ComPPI
TOP1 ESAM 25348397 N/A physical interaction ComPPI
TOP1 CIDEC 25348397 N/A physical interaction ComPPI
TOP1 SNRPGP15 25348397 N/A physical interaction ComPPI
TOP1 PRICKLE3 25348397 N/A physical interaction ComPPI
TOP1 DUS4L 25348397 N/A physical interaction ComPPI
TOP1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TOP1 NAT8B 15848144 24234451 25348397 association pull down ComPPI,IntAct
TOP1 TOPBP1 17006541 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TOP1 ABL1 15448168 24234451 25348397 physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
TOP1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
IK TOP1 25348397 N/A physical interaction ComPPI
RPS14 TOP1 25348397 N/A physical interaction ComPPI
TRIM26 TOP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOP1 TOP1 14525934 9756848 N/A experimental interaction detection HPRD
TDP1 TOP1 12618186 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
ALDH1B1 TOP1 24234451 30021884 physical association cross-linking study IntAct
ALDH2 TOP1 24234451 30021884 physical association cross-linking study IntAct
H2BC21 TOP1 24234451 30021884 physical association cross-linking study IntAct
TOP1 ASXL3 24234451 30021884 physical association cross-linking study IntAct
TOP1 ADAMTS16 24234451 30021884 physical association cross-linking study IntAct
TOP1 SLC25A3 24234451 30021884 physical association cross-linking study IntAct
SFPQ TOP1 15848144 27898060 9756848 stimulant N/A OmniPath
NONO TOP1 10858305 17481653 27898060 9756848 stimulant N/A OmniPath
ABL1 TOP1 15448168 20841568 27898060 stimulant N/A OmniPath
CDK1 TOP1 18408216 27898060 N/A N/A OmniPath
CSNK2A1 TOP1 23555599 26248194 27898060 2998765 8060534 N/A N/A OmniPath
TOP1 LIG3 13679147 27898060 inhibition N/A OmniPath
TOP1 LIG1 13679147 14699148 27898060 inhibition,stimulant N/A OmniPath
PARP1 TOP1 14699148 15247263 15848144 15911331 17145710 20875401 27898060 inhibition N/A OmniPath

Visualization










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