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GENE：ACVRL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACVRL1
FullNmae activin A receptor like type 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:175
EnsembleID ENSG00000139567
Uniprot P37023

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACVRL1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ACVRL1 GO:0001525,GO:0001525,GO:0001666,GO:0001701,GO:0001936,GO:0001937,GO:0001938,GO:0001946,GO:0001955,GO:0001974,GO:0002043,GO:0003203,GO:0004674,GO:0004675,GO:0005024,GO:0005025,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005886,GO:0005886,GO:0006275,GO:0006355,GO:0006468,GO:0006468,GO:0007162,GO:0007165,GO:0007179,GO:0007179,GO:0007507,GO:0008015,GO:0008217,GO:0008285,GO:0009953,GO:0009986,GO:0010596,GO:0010629,GO:0016361,GO:0019901,GO:0030308,GO:0030336,GO:0030425,GO:0030509,GO:0030509,GO:0030513,GO:0032332,GO:0032924,GO:0035313,GO:0035912,GO:0043025,GO:0043535,GO:0043537,GO:0045602,GO:0045603,GO:0045766,GO:0045893,GO:0045944,GO:0045944,GO:0046332,GO:0046332,GO:0046872,GO:0048185,GO:0050431,GO:0051895,GO:0060836,GO:0060840,GO:0060841,GO:0061154,GO:0061298,GO:0070724,GO:0071363,GO:0071560,GO:0071773,GO:0098821,GO:2000279

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACVRL1 hsa:94 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TGFBR2 ACVRL1 18333754 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACVRL1 TGFBR1 18333754 23180781 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
ACVRL1 ENG 15702480 16785228 18333754 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,cross-linking study,in-gel kinase assay InnateDB
ACVRL1 TGFBR3 18333754 23180781 physical association anti tag coimmunoprecipitation,cross-linking study InnateDB
ACVRL1 CAV1 18065769 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACVRL1 TGFBR2 18333754 23180781 physical association cross-linking study InnateDB
ACVRL1 NR1H2 12393874 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACVRL1 SMAD1 23331499 9748228 stimulation N/A SignaLink,SignaLink
SMAD7 ACVRL1 12023024 23331499 stimulation N/A SignaLink,SignaLink
TGFBR1 ACVRL1 14580334 23331499 stimulation N/A SignaLink,SignaLink
ACVR2B ACVRL1 16446785 23331499 stimulation N/A SignaLink,SignaLink
BAMBI ACVRL1 10519551 23331499 stimulation N/A SignaLink
PPP1CA ACVRL1 16571110 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SNX6 ACVRL1 20005715 interaction type N/A PSP
TGFBRAP1 ACVRL1 20005715 interaction type N/A PSP
SNX6 ACVRL1 11279102 18988627 20005715 20005715 N/A N/A SignaLink
TGFBRAP1 ACVRL1 11278302 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ACVRL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 ACVRL1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ACVRL1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ACVRL1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ACVRL1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ACVRL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACVRL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACVRL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACVRL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ACVRL1 20587022 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ACVRL1 20587022 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 ACVRL1 20803090 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 ACVRL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC ACVRL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 ACVRL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B ACVRL1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000024A59E ACVRL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000419B5A ACVRL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000759B6A ACVRL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041FA2C ACVRL1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000435A77 ACVRL1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AA845 ACVRL1 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000054A671 ACVRL1 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ACVRL1 ENG 22135298 phosphorylation N/A PhosphoSite
TGFB3 ACVRL1 25361965 interaction type N/A PTMCode2
ACVRL1 TGFB3 25361965 interaction type N/A PTMCode2
TGFB1 ACVRL1 25361965 interaction type N/A PTMCode2
ACVRL1 TGFB1 25361965 interaction type N/A PTMCode2
ACVR2A ACVRL1 25361965 interaction type N/A PTMCode2
ACVRL1 ACVR2A 25361965 interaction type N/A PTMCode2
ACVRL1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ACVRL1 25361965 interaction type N/A PTMCode2
ACVRL1 TGFBR2 25361965 interaction type N/A PTMCode2
TGFBR2 ACVRL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TGFB1 ACVRL1 10716993 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FKBP1A ACVRL1 25348397 N/A physical interaction ComPPI
XIAP ACVRL1 11356828 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD1 ACVRL1 25348397 N/A physical interaction ComPPI
TGFBR2 ACVRL1 10716993 14525934 25348397 N/A anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSP90AA1 ACVRL1 25348397 N/A physical interaction ComPPI
SNX6 ACVRL1 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NR1H2 ACVRL1 12393874 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ACVRL1 TGFBRAP1 11278302 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVRL1 ACVR2A 10187774 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ACVRL1 TGFB3 10187774 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ACVRL1 TSC22D1 25348397 N/A physical interaction ComPPI
ACVRL1 IGSF1 25348397 N/A physical interaction ComPPI
ACVRL1 HSP90AA2P 25348397 N/A physical interaction ComPPI
ACVRL1 BAMBI 25348397 N/A physical interaction ComPPI
ACVRL1 ENG 24234451 25348397 28564608 association anti bait coimmunoprecipitation,coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ACVRL1 PEG10 15611116 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ACVRL1 CSNK2B 25348397 N/A physical interaction ComPPI
ACVRL1 INHBA 25348397 N/A physical interaction ComPPI
ACVRL1 TGFBR1 14525934 14580334 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
ACVRL1 ACVR1 25348397 N/A physical interaction ComPPI
ACVRL1 SLC25A24 25348397 N/A physical interaction ComPPI
ACVRL1 LRG1 23868260 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ACVRL1 ITGA5 22940691 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
TGFBR2 ACVRL1 10187774 10716993 18333754 23868260 27898060 N/A N/A OmniPath
ACVRL1 SMAD1 27898060 9748228 inhibition,stimulant N/A OmniPath
TGFB1 ACVRL1 10187774 10716993 18333754 27898060 8242742 N/A N/A OmniPath
PPP1CA ACVRL1 16571110 27898060 stimulant N/A OmniPath
TGFBR1 ACVRL1 14580334 18333754 27898060 stimulant N/A OmniPath
SMAD7 ACVRL1 12023024 27898060 inhibition,stimulant N/A OmniPath
ACVRL1 ENG 10767348 15702480 16785228 18333754 20042635 23868260 27898060 N/A N/A OmniPath
BAMBI ACVRL1 10519551 27898060 stimulant N/A OmniPath
ACVR2B ACVRL1 16446785 27898060 stimulant N/A OmniPath
BMP10 ACVRL1 17068149 27898060 stimulant N/A OmniPath
GDF2 ACVRL1 17068149 27898060 stimulant N/A OmniPath

Visualization










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