Gene Information gene info

GENE:BMP7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BMP7
FullNmae bone morphogenetic protein 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1074
EnsembleID ENSG00000101144
Uniprot P18075

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BMP7 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMP7 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMP7 apoptosis 29247399 These results suggest that BMP7 plays a crucial role in Tmem100-regulated cell proliferation and apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
BMP7 GO:0001501,GO:0001503,GO:0001656,GO:0001657,GO:0001707,GO:0001823,GO:0001837,GO:0003272,GO:0003344,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0007411,GO:0008083,GO:0008201,GO:0009880,GO:0010628,GO:0010664,GO:0010718,GO:0016358,GO:0021502,GO:0030326,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030858,GO:0030902,GO:0031982,GO:0032088,GO:0032355,GO:0033280,GO:0034116,GO:0036305,GO:0042325,GO:0042475,GO:0043065,GO:0043434,GO:0045665,GO:0045666,GO:0045669,GO:0045746,GO:0045786,GO:0045839,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0048596,GO:0048738,GO:0048754,GO:0048762,GO:0048812,GO:0050768,GO:0051216,GO:0060037,GO:0060272,GO:0060391,GO:0060391,GO:0060411,GO:0060445,GO:0060485,GO:0060686,GO:0060687,GO:0060710,GO:0061384,GO:0062023,GO:0070487,GO:0071456,GO:0071773,GO:0072040,GO:0072125,GO:0072133,GO:0072134,GO:0072136,GO:0090336,GO:1900006,GO:1900106,GO:1901145,GO:1901223,GO:1905069,GO:1905312,GO:2000121

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BMP7 hsa:655 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
BMP7 hsa:655 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
BMP7 hsa:655 path:hsa04360 Axon guidance - Homo sapiens (human)
BMP7 hsa:655 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BMPR2 BMP7 18342887 23180781 physical association surface plasmon resonance,solid phase assay InnateDB
E2F1 BMP7 21310950 23180781 physical association anti tag coimmunoprecipitation InnateDB
BMP7 ACTN4 23180781 25416956 physical association two hybrid InnateDB
BMP7 KRTAP5-9 23180781 25416956 physical association two hybrid InnateDB
BMP7 TRIM27 23180781 25416956 physical association two hybrid InnateDB
BMP7 MTUS2 23180781 25416956 physical association two hybrid InnateDB
BMP7 KRTAP10-7 23180781 25416956 physical association two hybrid InnateDB
BMP7 KRTAP10-5 23180781 25416956 physical association two hybrid InnateDB
BMP7 KRTAP10-8 23180781 25416956 physical association two hybrid InnateDB
BMP7 KRTAP10-3 23180781 25416956 physical association two hybrid InnateDB
BMP7 ACVR2B 16446785 23331499 stimulation N/A SignaLink,SignaLink
BMP7 BMPR2 16446785 23331499 stimulation N/A SignaLink,SignaLink
BMP7 ACTR2 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR BMP7 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 BMP7 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BMP7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 BMP7 17452977 trascriptional regulation,stimulation inferred by curator TFlink
LDB1 BMP7 17452977 trascriptional regulation,stimulation inferred by curator TFlink
LMO4 BMP7 17452977 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 BMP7 19011694 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000148B91 BMP7 21172025 rna interference,inhibition northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 BMP7 23226240 rna interference,inhibition western blot miRSponge
URS0000096022 BMP7 19011694 24163368 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000148B91 BMP7 21172025 25416803 mrna cleavage,inhibition northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 BMP7 23226240 25416803 mrna cleavage,inhibition western blot TarBase
URS0000324096 BMP7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004F859B BMP7 24503542 25416803 26610487 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000042935A BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000A939F BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD BMP7 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001E3523 BMP7 25416803 26617798 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NOG BMP7 25361965 interaction type N/A PTMCode2
BMP7 NOG 25361965 interaction type N/A PTMCode2
BMPR1B BMP7 25361965 interaction type N/A PTMCode2
BMP7 BMPR1B 25361965 interaction type N/A PTMCode2
BMPER BMP7 25361965 interaction type N/A PTMCode2
BMP7 BMPER 25361965 interaction type N/A PTMCode2
ACVR2B BMP7 25361965 interaction type N/A PTMCode2
BMP7 ACVR2B 25361965 interaction type N/A PTMCode2
NCOA3 BMP7 25361965 interaction type N/A PTMCode2
BMP7 NCOA3 25361965 interaction type N/A PTMCode2
BMPR1A BMP7 25361965 interaction type N/A PTMCode2
BMP7 BMPR1A 25361965 interaction type N/A PTMCode2
ACVR2A BMP7 25361965 interaction type N/A PTMCode2
BMP7 ACVR2A 25361965 interaction type N/A PTMCode2
ACVR1 BMP7 25361965 interaction type N/A PTMCode2
BMP7 ACVR1 25361965 interaction type N/A PTMCode2
BMPR2 BMP7 25361965 interaction type N/A PTMCode2
BMP7 BMPR2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP10-5 BMP7 25348397 N/A two hybrid ComPPI
KRTAP5-9 BMP7 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP10-8 BMP7 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 KRTAP10-7 25348397 N/A two hybrid,physical interaction ComPPI
BMP7 BMPR2 14525934 25348397 7791754 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BMP7 SOSTDC1 14525934 14623234 15020244 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 NOG 12478285 14525934 24234451 25348397 N/A experimental interaction detection,x-ray crystallography,physical interaction ComPPI,HPRD,IntAct
BMP7 ENG 14525934 25348397 9872992 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 BMPR1A 14525934 25348397 7791754 8605097 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 BMPR1B 14525934 25348397 8605097 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 ACVR1 14525934 25348397 8006002 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 ACVR2A 12667445 14525934 25348397 9748228 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 ACVR2B 14525934 25348397 9748228 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BMP7 SMAD3 25348397 N/A physical interaction ComPPI
BMP7 ACTN4 25348397 N/A physical interaction ComPPI
BMP7 TRIM27 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 MTUS2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BMP7 KRTAP10-3 25348397 N/A physical interaction ComPPI
BMP7 NOTCH2NLA 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 TAZ 25348397 N/A physical interaction ComPPI
BMP7 ISLR 25348397 N/A physical interaction ComPPI
BMP7 UBR1 25348397 N/A physical interaction ComPPI
BMP7 VWA8 25348397 N/A physical interaction ComPPI
BMP7 GSTCD 25348397 N/A physical interaction ComPPI
BMP7 NPTX1 25348397 N/A physical interaction ComPPI
BMP7 AMD1 25348397 N/A physical interaction ComPPI
BMP7 CNTNAP3B 25348397 N/A physical interaction ComPPI
BMP7 CILK1 25348397 N/A physical interaction ComPPI
BMP7 NAAA 25348397 N/A physical interaction ComPPI
BMP7 OLFM4 25348397 N/A physical interaction ComPPI
BMP7 STK26 25348397 N/A physical interaction ComPPI
BMP7 GDF11 25348397 N/A physical interaction ComPPI
BMP7 DKKL1 25348397 N/A physical interaction ComPPI
BMP7 OLFM2 25348397 N/A physical interaction ComPPI
BMP7 GNB2 25348397 N/A physical interaction ComPPI
BMP7 BTBD1 25348397 N/A physical interaction ComPPI
BMP7 SLAMF1 25348397 N/A physical interaction ComPPI
BMP7 PTPRK 25348397 N/A physical interaction ComPPI
BMP7 BEGAIN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 KHDRBS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 KRTAP3-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 KRTAP10-9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 KRTAP9-8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 CCDC125 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMP7 KRTAP12-3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDCD10 BMP7 25348397 N/A physical interaction ComPPI
PPP2R5D BMP7 25348397 N/A physical interaction ComPPI
NCOA3 BMP7 14525934 7791754 N/A experimental interaction detection HPRD
GDF7 BMP7 12741987 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
CHRDL2 BMP7 14525934 14660436 N/A experimental interaction detection HPRD
BMP7 TWSG1 15843411 27898060 N/A N/A OmniPath
BMP7 BMPR2 18342887 27898060 7644468 7791754 stimulant N/A OmniPath
BMP7 ACVR2B 27898060 9748228 stimulant N/A OmniPath
BMP7 ACTR2 16446785 27898060 stimulant N/A OmniPath
BMP7 ACVR2A 12667445 27898060 9748228 stimulant N/A OmniPath

Visualization