GENE:BMP7
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | BMP7 |
FullNmae | bone morphogenetic protein 7 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:1074 |
EnsembleID | ENSG00000101144 |
Uniprot | P18075 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
BMP7 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
BMP7 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
BMP7 | apoptosis | 29247399 | These results suggest that BMP7 plays a crucial role in Tmem100-regulated cell proliferation and apoptosis. | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
BMP7 | GO:0001501,GO:0001503,GO:0001656,GO:0001657,GO:0001707,GO:0001823,GO:0001837,GO:0003272,GO:0003344,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0007411,GO:0008083,GO:0008201,GO:0009880,GO:0010628,GO:0010664,GO:0010718,GO:0016358,GO:0021502,GO:0030326,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030858,GO:0030902,GO:0031982,GO:0032088,GO:0032355,GO:0033280,GO:0034116,GO:0036305,GO:0042325,GO:0042475,GO:0043065,GO:0043434,GO:0045665,GO:0045666,GO:0045669,GO:0045746,GO:0045786,GO:0045839,GO:0045892,GO:0045893,GO:0045893,GO:0045944,GO:0048596,GO:0048738,GO:0048754,GO:0048762,GO:0048812,GO:0050768,GO:0051216,GO:0060037,GO:0060272,GO:0060391,GO:0060391,GO:0060411,GO:0060445,GO:0060485,GO:0060686,GO:0060687,GO:0060710,GO:0061384,GO:0062023,GO:0070487,GO:0071456,GO:0071773,GO:0072040,GO:0072125,GO:0072133,GO:0072134,GO:0072136,GO:0090336,GO:1900006,GO:1900106,GO:1901145,GO:1901223,GO:1905069,GO:1905312,GO:2000121 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
BMP7 | hsa:655 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
BMP7 | hsa:655 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
BMP7 | hsa:655 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
BMP7 | hsa:655 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
BMPR2 | BMP7 | 18342887 23180781 | physical association | surface plasmon resonance,solid phase assay | InnateDB |
E2F1 | BMP7 | 21310950 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
BMP7 | ACTN4 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | KRTAP5-9 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | TRIM27 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | MTUS2 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | KRTAP10-7 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | KRTAP10-5 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | KRTAP10-8 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | KRTAP10-3 | 23180781 25416956 | physical association | two hybrid | InnateDB |
BMP7 | ACVR2B | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
BMP7 | BMPR2 | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
BMP7 | ACTR2 | 16446785 23331499 | stimulation | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | BMP7 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
GATA2 | BMP7 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
CEBPA | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXP1 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
PRDM14 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RUNX1 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TRIM28 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | BMP7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HDAC2 | BMP7 | 17452977 | trascriptional regulation,stimulation | inferred by curator | TFlink |
LDB1 | BMP7 | 17452977 | trascriptional regulation,stimulation | inferred by curator | TFlink |
LMO4 | BMP7 | 17452977 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000096022 | BMP7 | 19011694 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS0000148B91 | BMP7 | 21172025 | rna interference,inhibition | northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
URS00000EED18 | BMP7 | 23226240 | rna interference,inhibition | western blot | miRSponge |
URS0000096022 | BMP7 | 19011694 24163368 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000148B91 | BMP7 | 21172025 25416803 | mrna cleavage,inhibition | northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS00000EED18 | BMP7 | 23226240 25416803 | mrna cleavage,inhibition | western blot | TarBase |
URS0000324096 | BMP7 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00004F859B | BMP7 | 24503542 25416803 26610487 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS000042935A | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000AA464 | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001FC26E | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000334286 | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001CE046 | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000411752 | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000007A060 | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000A939F | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000753AD | BMP7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001E3523 | BMP7 | 25416803 26617798 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
NOG | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | NOG | 25361965 | interaction type | N/A | PTMCode2 |
BMPR1B | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | BMPR1B | 25361965 | interaction type | N/A | PTMCode2 |
BMPER | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | BMPER | 25361965 | interaction type | N/A | PTMCode2 |
ACVR2B | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
NCOA3 | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | NCOA3 | 25361965 | interaction type | N/A | PTMCode2 |
BMPR1A | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | BMPR1A | 25361965 | interaction type | N/A | PTMCode2 |
ACVR2A | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | ACVR2A | 25361965 | interaction type | N/A | PTMCode2 |
ACVR1 | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | ACVR1 | 25361965 | interaction type | N/A | PTMCode2 |
BMPR2 | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
BMP7 | BMPR2 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
KRTAP10-5 | BMP7 | 25348397 | N/A | two hybrid | ComPPI |
KRTAP5-9 | BMP7 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
KRTAP10-8 | BMP7 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | KRTAP10-7 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
BMP7 | BMPR2 | 14525934 25348397 7791754 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
BMP7 | SOSTDC1 | 14525934 14623234 15020244 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | NOG | 12478285 14525934 24234451 25348397 | N/A | experimental interaction detection,x-ray crystallography,physical interaction | ComPPI,HPRD,IntAct |
BMP7 | ENG | 14525934 25348397 9872992 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | BMPR1A | 14525934 25348397 7791754 8605097 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | BMPR1B | 14525934 25348397 8605097 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | ACVR1 | 14525934 25348397 8006002 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | ACVR2A | 12667445 14525934 25348397 9748228 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | ACVR2B | 14525934 25348397 9748228 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
BMP7 | SMAD3 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | ACTN4 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | TRIM27 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | MTUS2 | 21516116 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
BMP7 | KRTAP10-3 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | NOTCH2NLA | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | TAZ | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | ISLR | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | UBR1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | VWA8 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | GSTCD | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | NPTX1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | AMD1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | CNTNAP3B | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | CILK1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | NAAA | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | OLFM4 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | STK26 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | GDF11 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | DKKL1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | OLFM2 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | GNB2 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | BTBD1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | SLAMF1 | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | PTPRK | 25348397 | N/A | physical interaction | ComPPI |
BMP7 | BEGAIN | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | KHDRBS2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | KRTAP3-1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | KRTAP10-9 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | KRTAP9-8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | CCDC125 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
BMP7 | KRTAP12-3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
PDCD10 | BMP7 | 25348397 | N/A | physical interaction | ComPPI |
PPP2R5D | BMP7 | 25348397 | N/A | physical interaction | ComPPI |
NCOA3 | BMP7 | 14525934 7791754 | N/A | experimental interaction detection | HPRD |
GDF7 | BMP7 | 12741987 14525934 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |
CHRDL2 | BMP7 | 14525934 14660436 | N/A | experimental interaction detection | HPRD |
BMP7 | TWSG1 | 15843411 27898060 | N/A | N/A | OmniPath |
BMP7 | BMPR2 | 18342887 27898060 7644468 7791754 | stimulant | N/A | OmniPath |
BMP7 | ACVR2B | 27898060 9748228 | stimulant | N/A | OmniPath |
BMP7 | ACTR2 | 16446785 27898060 | stimulant | N/A | OmniPath |
BMP7 | ACVR2A | 12667445 27898060 9748228 | stimulant | N/A | OmniPath |