GENE：SPHK2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SPHK2 |
| FullNmae | sphingosine kinase 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18859 |
| EnsembleID | ENSG00000063176 |
| Uniprot | Q9NRA0 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SPHK2 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| SPHK2 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SPHK2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SPHK2 | GO:0000786,GO:0001568,GO:0002720,GO:0003376,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005739,GO:0005743,GO:0005765,GO:0005783,GO:0005829,GO:0005829,GO:0006669,GO:0006669,GO:0006670,GO:0007420,GO:0008283,GO:0008284,GO:0008481,GO:0008481,GO:0016020,GO:0016020,GO:0016310,GO:0017050,GO:0017050,GO:0017050,GO:0030148,GO:0030308,GO:0031267,GO:0032736,GO:0032755,GO:0032760,GO:0033008,GO:0038036,GO:0042393,GO:0043065,GO:0043065,GO:0043122,GO:0043231,GO:0043306,GO:0045815,GO:0046512,GO:0046512,GO:0046512,GO:0090037,GO:0090280,GO:1903426,GO:1904628,GO:1904959,GO:2000304,GO:2001169 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SPHK2 | hsa:56848 | path:hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| SPHK2 | hsa:56848 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | SPHK2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | SPHK2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | SPHK2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| NR1I2 | SPHK2 | 19129222 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | SPHK2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| E2F1 | SPHK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | SPHK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SPHK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SPHK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SPHK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LYN | SPHK2 | 14525934 16316995 24234451 25348397 | N/A | anti bait coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| FHL2 | SPHK2 | 16888242 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| FYN | SPHK2 | 14525934 16316995 24234451 25348397 | N/A | anti bait coimmunoprecipitation,experimental interaction detection,in vivo | ComPPI,HPRD,IntAct |
| RAB9A | SPHK2 | 25348397 | N/A | physical interaction | ComPPI |
| H3C1 | SPHK2 | 25348397 | N/A | physical interaction | ComPPI |
| HECW2 | SPHK2 | 25348397 | N/A | physical interaction | ComPPI |
| PRKD1 | SPHK2 | 17635916 27898060 | N/A | N/A | OmniPath |
| SPHK2 | HDAC2 | 19729656 27898060 | inhibition | N/A | OmniPath |
| MAPK3 | SPHK2 | 17311928 27898060 | stimulant | N/A | OmniPath |
| SPHK2 | HDAC1 | 19729656 27898060 | inhibition | N/A | OmniPath |
| MAPK1 | SPHK2 | 17311928 27898060 | stimulant | N/A | OmniPath |