GENE：ACVR1C
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACVR1C |
| FullNmae | activin A receptor type 1C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:18123 |
| EnsembleID | ENSG00000123612 |
| Uniprot | Q8NER5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACVR1C | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACVR1C | GO:0001834,GO:0002021,GO:0004674,GO:0005524,GO:0005886,GO:0005886,GO:0006468,GO:0006468,GO:0007399,GO:0009749,GO:0016361,GO:0016361,GO:0019838,GO:0019915,GO:0030073,GO:0030154,GO:0030262,GO:0032868,GO:0032924,GO:0038092,GO:0038100,GO:0043065,GO:0043280,GO:0046676,GO:0046872,GO:0048179,GO:0048179,GO:0071363,GO:1901164,GO:1901383 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACVR1C | hsa:130399 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| ACVR1C | hsa:130399 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| ACVR1C | hsa:130399 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| FOXP3 | ACVR1C | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | ACVR1C | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CTCF | ACVR1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ACVR1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ACVR1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ACVR1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACVR1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ACVR1C | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD3 | ACVR1C | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | ACVR1C | 21224400 | rna interference,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | miRSponge |
| URS0000096022 | ACVR1C | 21224400 | rna interference,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00003AD231 | ACVR1C | 21224400 | rna interference,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00001B9F58 | ACVR1C | 21224400 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000321A1A | ACVR1C | 21224400 | rna interference,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | miRSponge |
| URS00001B9F58 | ACVR1C | 21224400 23424236 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00003AD231 | ACVR1C | 21224400 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000096022 | ACVR1C | 21224400 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000321A1A | ACVR1C | 21224400 25416803 | mrna cleavage,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | TarBase |
| URS00003380CC | ACVR1C | 21224400 25416803 | mrna cleavage,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | TarBase |
| URS0000072E4C | ACVR1C | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004407DC | ACVR1C | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018E72A | ACVR1C | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ACVR1C | INHBB | 25361965 | interaction type | N/A | PTMCode2 |
| INHBB | ACVR1C | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR1C | TDGF1 | 25361965 | interaction type | N/A | PTMCode2 |
| TDGF1 | ACVR1C | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR1C | SMAD4 | 25361965 | interaction type | N/A | PTMCode2 |
| SMAD4 | ACVR1C | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HSP90AB1 | ACVR1C | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| HSP90AA1 | ACVR1C | 25348397 | N/A | physical interaction | ComPPI |
| TDGF1 | ACVR1C | 11485994 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACVR1C | INHBB | 14525934 15196700 24234451 25241761 25348397 | physical association | experimental interaction detection,physical interaction,in vitro,proximity ligation assay | ComPPI,HPRD,IntAct |
| ACVR1C | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| NODAL | ACVR1C | 12606401 15531507 27898060 | stimulant | N/A | OmniPath |