GENE：BMP6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BMP6 |
| FullNmae | bone morphogenetic protein 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1073 |
| EnsembleID | ENSG00000153162 |
| Uniprot | P22004 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BMP6 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BMP6 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BMP6 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BMP6 | GO:0000122,GO:0001501,GO:0001649,GO:0001654,GO:0001822,GO:0001938,GO:0001958,GO:0003323,GO:0005125,GO:0005515,GO:0005615,GO:0005615,GO:0006879,GO:0006954,GO:0006955,GO:0008083,GO:0008284,GO:0010628,GO:0014823,GO:0030182,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030539,GO:0031666,GO:0031982,GO:0032026,GO:0032332,GO:0032349,GO:0032526,GO:0043117,GO:0045603,GO:0045666,GO:0045669,GO:0045944,GO:0045944,GO:0045944,GO:0045944,GO:0046982,GO:0050679,GO:0050714,GO:0050731,GO:0051216,GO:0051384,GO:0060348,GO:0060391,GO:0060395,GO:0060586,GO:0060586,GO:0070700,GO:0071260,GO:0071281,GO:0071773,GO:1903392,GO:2000048,GO:2000860 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| BMP6 | hsa:654 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| BMP6 | hsa:654 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| BMP6 | hsa:654 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| BMP6 | hsa:654 | path:hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMP6 | HJV | 19252486 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EGR1 | BMP6 | 20690147 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BMP6 | CEBPD | 21072181 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| BMP6 | ACVR2B | 10504300 16446785 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| BMP6 | BMPR2 | 10504300 16446785 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| BMP6 | AMHR2 | 16446785 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | BMP6 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | BMP6 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | BMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ESR1 | BMP6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCOA3 | BMP6 | 10504300 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SMAD5 | BMP6 | 10504300 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMPR2 | BMP6 | 11401330 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| BMPR1B | BMP6 | 10504300 11401330 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACVR2B | BMP6 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | BMP6 | 25348397 | N/A | physical interaction | ComPPI |
| BMPR1A | BMP6 | 10504300 11401330 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| SOSTDC1 | BMP6 | 14525934 14623234 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| BMPER | BMP6 | 12897139 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMP6 | ACVR2A | 10504300 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| BMP6 | TNFAIP6 | 18586671 24234451 25348397 | N/A | enzyme linked immunosorbent assay | ComPPI,IntAct |
| CHRDL2 | BMP6 | 14525934 14660436 | N/A | experimental interaction detection | HPRD |
| BMP6 | HJV | 19252486 27898060 | N/A | N/A | OmniPath |