Gene Information gene info

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GENE：DFFA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DFFA
FullNmae DNA fragmentation factor subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2772
EnsembleID ENSG00000160049
Uniprot O00273

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DFFA necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DFFA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DFFA apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DFFA GO:0000785,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0005886,GO:0006309,GO:0019904,GO:0032076,GO:0032991,GO:0043065,GO:0044183,GO:0060703,GO:0061077,GO:0070242,GO:1900118,GO:1900118,GO:1902511

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DFFA hsa:1676 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GZMB DFFA 17283187 23180781 protein cleavage protease assay InnateDB
CASP3 DFFA 11406587 23180781 protein cleavage protease assay InnateDB
GZMH DFFA 17765974 23180781 protein cleavage protease assay InnateDB
GZMM DFFA 16818775 23180781 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
CIDEB DFFA 20005715 interaction type N/A PSP
YWHAB DFFA 20005715 interaction type N/A PSP,SignaLink
YWHAG DFFA 20005715 interaction type N/A PSP
YWHAQ DFFA 20005715 interaction type N/A PSP,SignaLink
YWHAZ DFFA 20005715 interaction type N/A PSP
YWHAZ DFFA 15324660 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 DFFA 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC DFFA 12747840 18500556 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DFFA 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DFFA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DFFA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DFFA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DFFA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 DFFA 20687965 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 DFFA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000013ABA3 DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE DFFA 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000049704B DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000E1E9E DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001B9F58 DFFA 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058276F DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD DFFA 23824327 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000EC1BE DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA DFFA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 DFFA 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00001FC26E DFFA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000018D2BE DFFA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000411752 DFFA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004CCA62 DFFA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002B7450 DFFA 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027080C DFFA 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
GZMB DFFA 25361965 interaction type N/A PTMCode2
DFFA GZMB 25361965 interaction type N/A PTMCode2
CIDEB DFFA 25361965 interaction type N/A PTMCode2
DFFA CIDEB 25361965 interaction type N/A PTMCode2
CASP7 DFFA 25361965 interaction type N/A PTMCode2
DFFA CASP7 25361965 interaction type N/A PTMCode2
CASP3 DFFA 25361965 interaction type N/A PTMCode2
DFFA CASP3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NECAB2 DFFA 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PRKAA2 DFFA 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TSPYL4 DFFA 25348397 N/A physical interaction ComPPI
TUBB DFFA 25348397 N/A physical interaction ComPPI
YWHAG DFFA 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
DUSP12 DFFA 25348397 N/A physical interaction ComPPI
EIF5 DFFA 25348397 N/A physical interaction ComPPI
CASP3 DFFA 11752060 14525934 24234451 25241761 25348397 9108473 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
TTN DFFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAB DFFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GAPDH DFFA 25348397 N/A physical interaction ComPPI
YWHAZ DFFA 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
NTRK1 DFFA 25348397 N/A physical interaction ComPPI
HERC1 DFFA 25348397 N/A physical interaction ComPPI
CASP7 DFFA 10318789 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HNRNPL DFFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPS6KA3 DFFA 25348397 N/A physical interaction ComPPI
EIF6 DFFA 25348397 N/A physical interaction ComPPI
EWSR1 DFFA 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
YWHAQ DFFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TOM1L2 DFFA 25348397 N/A physical interaction ComPPI
TUBA1A DFFA 25348397 N/A physical interaction ComPPI
SEPTIN5 DFFA 25348397 N/A physical interaction ComPPI
HSPB1 DFFA 24234451 25277244 25348397 physical association anti bait coimmunoprecipitation,reverse ras recruitment system,physical interaction ComPPI,IntAct
BAK1 DFFA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFA DFFB 10409614 10527860 10527861 10932250 11371636 14525934 17353931 19882353 24234451 25348397 9108473 9422506 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,filter binding,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
DFFA CIDEB 10619428 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DFFA STRN4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DFFA MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFA NAP1L5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFA TMBIM4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFA USP15 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DFFA LTB4R2 25348397 N/A physical interaction ComPPI
DFFA GZMM 25348397 N/A physical interaction ComPPI
DFFA GZMB 11406587 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DFFA BZW2 25348397 N/A physical interaction ComPPI
DFFA CNBP 25348397 N/A physical interaction ComPPI
DFFA ATG3 25348397 N/A physical interaction ComPPI
DFFA CTPS1 25348397 N/A physical interaction ComPPI
DFFA FERMT2 25348397 N/A physical interaction ComPPI
DFFA MAT2A 25348397 N/A physical interaction ComPPI
DFFA MAT2B 25348397 N/A physical interaction ComPPI
DFFA PFAS 25348397 N/A physical interaction ComPPI
DFFA PPP5C 25348397 N/A physical interaction ComPPI
DFFA MOV10 25348397 N/A physical interaction ComPPI
DFFA NXF1 25348397 N/A physical interaction ComPPI
DFFA GNB4 25348397 N/A physical interaction ComPPI
DFFA EFTUD2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DFFA CYP4B1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DFFA UVRAG 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DFFA LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CKB DFFA 25348397 N/A physical interaction ComPPI
ISOC1 DFFA 25348397 N/A physical interaction ComPPI
DFFA DFFA 17353931 24234451 physical association anti bait coimmunoprecipitation IntAct
GZMB DFFA 11406587 17283187 27898060 inhibition N/A OmniPath
CASP7 DFFA 10318789 27898060 inhibition,stimulant N/A OmniPath
DFFA CASP3 11406587 11752060 18723680 25241761 27898060 9108473 N/A N/A OmniPath
CASP3 DFFA 11406587 11752060 12655299 18723680 25241761 27898060 9108473 9422506 9422513 9786842 inhibition,stimulant N/A OmniPath
DFFA DFFB 10409614 10527860 10527861 10932250 11371636 12655299 15572351 17353931 19882353 26186194 27898060 9108473 9422506 9422513 inhibition N/A OmniPath

Visualization










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