Gene Information gene info

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GENE：PIDD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PIDD1
FullNmae p53-induced death domain protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16491
EnsembleID ENSG00000177595
Uniprot Q9HB75

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PIDD1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIDD1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIDD1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIDD1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PIDD1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PIDD1 GO:0004175,GO:0004175,GO:0005123,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005737,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0006915,GO:0006919,GO:0006919,GO:0006974,GO:0006974,GO:0006977,GO:0007165,GO:0008625,GO:0016540,GO:0043065,GO:0043065,GO:0043066,GO:0043122,GO:0051092,GO:1905369

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PIDD1 hsa:55367 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
PIDD1 hsa:55367 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
PIDD1 hsa:55367 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PIDD1 CRADD 20005715 interaction type N/A PSP
PIDD1 RIPK1 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PIDD1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF PIDD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PIDD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PIDD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PIDD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PIDD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PIDD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PIDD1 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PIDD1 IKBKG 25361965 interaction type N/A PTMCode2
IKBKG PIDD1 25361965 interaction type N/A PTMCode2
CASP2 PIDD1 25361965 interaction type N/A PTMCode2
PIDD1 CASP2 25361965 interaction type N/A PTMCode2
FADD PIDD1 25361965 interaction type N/A PTMCode2
PIDD1 FADD 25361965 interaction type N/A PTMCode2
RIPK1 PIDD1 25361965 interaction type N/A PTMCode2
PIDD1 RIPK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ANP32B PIDD1 25348397 N/A physical interaction ComPPI
EFEMP2 PIDD1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CRYAB PIDD1 25348397 N/A physical interaction ComPPI
PCNA PIDD1 25348397 N/A physical interaction ComPPI
TRIM32 PIDD1 25348397 N/A physical interaction ComPPI
KEAP1 PIDD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCDC85B PIDD1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MDFI PIDD1 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PRKDC PIDD1 25348397 N/A physical interaction ComPPI
MAFG PIDD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HAX1 PIDD1 25348397 N/A physical interaction ComPPI
PRDX1 PIDD1 25348397 N/A physical interaction ComPPI
FADD PIDD1 10825539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SOX8 PIDD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
POLD1 PIDD1 25348397 N/A physical interaction ComPPI
RIPK1 PIDD1 17159900 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MADD PIDD1 10825539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ERCC5 PIDD1 25348397 N/A physical interaction ComPPI
PPP6C PIDD1 25348397 N/A physical interaction ComPPI
CASP2 PIDD1 14525934 15073321 16652156 24234451 25348397 colocalization,association affinity chromatography technology,anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
RFC5 PIDD1 25348397 N/A physical interaction ComPPI
CRADD PIDD1 14525934 15073321 16652156 17159900 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD,IntAct
DDB1 PIDD1 25348397 N/A physical interaction ComPPI
RFC4 PIDD1 25348397 N/A physical interaction ComPPI
SENP3 PIDD1 25348397 N/A physical interaction ComPPI
TEAD3 PIDD1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NUP93 PIDD1 25348397 N/A physical interaction ComPPI
ERCC2 PIDD1 25348397 N/A physical interaction ComPPI
MCM7 PIDD1 25348397 N/A physical interaction ComPPI
POLR2B PIDD1 25348397 N/A physical interaction ComPPI
PIDD1 IKBKG 25348397 N/A physical interaction ComPPI
PIDD1 TELO2 25348397 N/A physical interaction ComPPI
PIDD1 RPAP3 25348397 N/A physical interaction ComPPI
PIDD1 FANCI 25348397 N/A physical interaction ComPPI
PIDD1 BIVM 25348397 N/A physical interaction ComPPI
PIDD1 AIFM1 25348397 N/A physical interaction ComPPI
PIDD1 AFP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PIDD1 MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
PIDD1 PIDD1 17159900 24234451 physical association anti tag coimmunoprecipitation IntAct
H3-4 PIDD1 24234451 30021884 physical association cross-linking study IntAct
H1-1 PIDD1 24234451 30021884 physical association cross-linking study IntAct
PIDD1 FADD 10825539 16189514 16360037 27898060 N/A N/A OmniPath
PIDD1 MADD 10825539 27898060 N/A N/A OmniPath
PIDD1 CRADD 15073321 16189514 16360037 16652156 17159900 17289572 17329820 18845684 19203584 20406701 20872280 20935634 20966961 21415862 23049853 27898060 stimulant N/A OmniPath
PIDD1 IKBKG 16360037 16965765 27898060 stimulant N/A OmniPath
PIDD1 CASP2 15073321 16360037 16652156 21415862 27898060 stimulant N/A OmniPath
TP53 PIDD1 10973264 27898060 stimulant N/A OmniPath
PIDD1 RIPK1 16360037 17159900 27898060 stimulant N/A OmniPath
PIDD1 PRKDC 19203584 27898060 stimulant N/A OmniPath

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