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GENE：NFATC3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NFATC3
FullNmae nuclear factor of activated T cells 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7777
EnsembleID ENSG00000072736
Uniprot Q12968

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NFATC3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFATC3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NFATC3 GO:0000122,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001228,GO:0001228,GO:0001816,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005829,GO:0006357,GO:0006954,GO:0008134,GO:0033173,GO:0045944,GO:0045944,GO:1902894,GO:1905064,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NFATC3 hsa:4775 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04148 Efferocytosis - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04218 Cellular senescence - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04360 Axon guidance - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05135 Yersinia infection - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05161 Hepatitis B - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
NFATC3 hsa:4775 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFATC3 TNF 16027109 23180781 physical association DNase I footprinting InnateDB
TNFSF11 NFATC3 19671684 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL2 NFATC3 15980153 23180781 physical association electrophoretic mobility supershift assay InnateDB
NFATC3 SRF 15857835 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC3 CXCR5 14993281 23180781 physical association electrophoretic mobility shift assay InnateDB
PPP3CB NFATC3 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome
PPP3R1 NFATC3 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome
PPP3CA NFATC3 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR NFATC3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 NFATC3 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NFATC3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NFATC3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NFATC3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 NFATC3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NFATC3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NFATC3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000CF1D2 NFATC3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D NFATC3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 NFATC3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000260A3A NFATC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D NFATC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002367FA NFATC3 24014023 25416803 25767890 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003CF1AD NFATC3 25159093 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003A5E54 NFATC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C NFATC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 NFATC3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 NFATC3 25416803 26473838 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000302909 NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00003D8730 NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000519450 NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000306C70 NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000077AED NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00003883FE NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS000037D7E5 NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00001383CF NFATC3 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS00002C02E4 NFATC3 25416803 28735896 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK1A1 NFATC3 22135298 phosphorylation N/A PhosphoSite
MAPK9 NFATC3 22135298 phosphorylation N/A PhosphoSite
NFATC3 FOS 25361965 interaction type N/A PTMCode2
FOS NFATC3 25361965 interaction type N/A PTMCode2
NFATC3 MAPK8 25361965 interaction type N/A PTMCode2
MAPK8 NFATC3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAPK9 NFATC3 14525934 25348397 9374467 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CDK6 NFATC3 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
EGLN3 NFATC3 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MAPK8 NFATC3 25348397 N/A physical interaction ComPPI
JUN NFATC3 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
NCOA3 NFATC3 25348397 N/A physical interaction ComPPI
SUFU NFATC3 25348397 N/A physical interaction ComPPI
ENO1 NFATC3 25348397 N/A physical interaction ComPPI
RAF1 NFATC3 24234451 24330068 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
ZMIZ1 NFATC3 25348397 N/A physical interaction ComPPI
SHMT2 NFATC3 25348397 N/A physical interaction ComPPI
STK40 NFATC3 25348397 N/A physical interaction ComPPI
NXF1 NFATC3 25348397 N/A physical interaction ComPPI
MOV10 NFATC3 25348397 N/A physical interaction ComPPI
CSNK1A1 NFATC3 14525934 25348397 9630228 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NFATC3 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NFATC3 TTF1 14525934 15173172 27898060 N/A experimental interaction detection HPRD,OmniPath
NFATC3 FOS 14525934 9121455 N/A experimental interaction detection HPRD
SRF NFATC3 15857835 27898060 N/A N/A OmniPath
PPP3CA NFATC3 10860980 11509611 16407284 21880741 27898060 stimulant N/A OmniPath
CSNK1A1 NFATC3 27898060 9630228 inhibition N/A OmniPath
MAPK9 NFATC3 14517246 27898060 9374467 9630228 inhibition,stimulant N/A OmniPath
MAPK8 NFATC3 14517246 27898060 inhibition N/A OmniPath

Visualization










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