GENE：ACVR2B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACVR2B |
| FullNmae | activin A receptor type 2B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:174 |
| EnsembleID | ENSG00000114739 |
| Uniprot | Q13705 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACVR2B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ACVR2B | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACVR2B | GO:0000122,GO:0001702,GO:0001822,GO:0001946,GO:0001974,GO:0004674,GO:0004674,GO:0004712,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005886,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0007368,GO:0007498,GO:0007507,GO:0009749,GO:0009791,GO:0009952,GO:0016310,GO:0016362,GO:0017002,GO:0019209,GO:0019838,GO:0030073,GO:0030324,GO:0030501,GO:0030509,GO:0030509,GO:0031016,GO:0032924,GO:0032924,GO:0032927,GO:0032991,GO:0035265,GO:0042475,GO:0043235,GO:0045669,GO:0046872,GO:0048179,GO:0048185,GO:0048617,GO:0048705,GO:0060021,GO:0060836,GO:0060840,GO:0060841,GO:0061298,GO:0071363,GO:0120163 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACVR2B | hsa:93 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| ACVR2B | hsa:93 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| ACVR2B | hsa:93 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| ACVR2B | hsa:93 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ERBIN | ACVR2B | 15123239 23180781 | physical association | peptide array | InnateDB |
| ACVR2B | BMP2 | 17295905 23180781 | physical association | surface plasmon resonance,x-ray crystallography | InnateDB |
| ACVR2B | BMPR1A | 16446785 17295905 23180781 23331499 | stimulation,physical association | x-ray crystallography | InnateDB,SignaLink,SignaLink |
| ACVR2B | ACVR2A | 12364468 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| ACVR2B | ACVR1B | 12364468 16446785 18988627 23180781 23331499 8622651 | stimulation,physical association | anti tag coimmunoprecipitation | InnateDB,SignaLink,SignaLink |
| ACVR2B | ACVR1 | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
| ACVR2B | BMPR1B | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
| INHBA | ACVR2B | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
| BMP7 | ACVR2B | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
| BMP6 | ACVR2B | 10504300 16446785 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| BMP2 | ACVR2B | 15064755 16446785 18988627 23331499 | stimulation | N/A | SignaLink,SignaLink |
| ACVR2B | ACVRL1 | 16446785 23331499 | stimulation | N/A | SignaLink,SignaLink |
| ACVR2B | ACVR1C | 16446785 23331499 | stimulation | N/A | SignaLink |
| GDF11 | ACVR2B | 16446785 16845371 23331499 | stimulation | N/A | SignaLink |
| NODAL | ACVR2B | 16446785 23331499 | stimulation | N/A | SignaLink |
| GDF5 | ACVR2B | 16446785 23331499 8702914 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ACVR2B | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | ACVR2B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ACVR2B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | ACVR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ACVR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ACVR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACVR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ACVR2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003E1A9 | ACVR2B | 22431721 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00000B59A2 | ACVR2B | 22431721 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS0000171525 | ACVR2B | 22431721 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00000F31F4 | ACVR2B | 22431721 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS00000B59A2 | ACVR2B | 19074876 22431721 25416803 | mrna cleavage,inhibition | array technology,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS00000F31F4 | ACVR2B | 22431721 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS000003E1A9 | ACVR2B | 22431721 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000171525 | ACVR2B | 22431721 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | ACVR2B | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000821E0 | ACVR2B | 20371350 22012620 25416803 26701625 27292025 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS0000170CF4 | ACVR2B | 22942087 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000008F0CF | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000555DA6 | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037E170 | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001123BD | ACVR2B | 20371350 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | ACVR2B | 20371350 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | ACVR2B | 20371350 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | ACVR2B | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFEC1 | ACVR2B | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052E1A6 | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C36BD | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FA076 | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F8148 | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CD810 | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004283FE | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001FFA8C | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004DA9DB | ACVR2B | 22291592 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020CEC2 | ACVR2B | 20371350 22012620 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E1509 | ACVR2B | 20371350 22012620 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000FC8EB | ACVR2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000004203C | ACVR2B | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A71AD | ACVR2B | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F8DA | ACVR2B | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | ACVR2B | 23313552 23824327 24906430 25416803 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | ACVR2B | 23313552 23824327 24906430 25416803 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D69F6 | ACVR2B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CF1D2 | ACVR2B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170D8B | ACVR2B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003003B4 | ACVR2B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | ACVR2B | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000183BED | ACVR2B | 25416803 25518011 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry | TarBase |
| URS000028DE3F | ACVR2B | 25416803 27292025 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GDF11 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | GDF11 | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | IGSF1 | 25361965 | interaction type | N/A | PTMCode2 |
| IGSF1 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | SNX6 | 25361965 | interaction type | N/A | PTMCode2 |
| SNX6 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | GDF5 | 25361965 | interaction type | N/A | PTMCode2 |
| GDF5 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP2 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP7 | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| BMPR1A | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | BMPR1A | 25361965 | interaction type | N/A | PTMCode2 |
| INHBB | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | INHBB | 25361965 | interaction type | N/A | PTMCode2 |
| SYNJ2BP | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | SYNJ2BP | 25361965 | interaction type | N/A | PTMCode2 |
| INHBC | ACVR2B | 25361965 | interaction type | N/A | PTMCode2 |
| ACVR2B | INHBC | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMP7 | ACVR2B | 14525934 25348397 9748228 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| HSP90AB1 | ACVR2B | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| ERBIN | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| TGFBR2 | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| SMAD7 | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| SMAD2 | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| PDGFRB | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| SNX1 | ACVR2B | 11279102 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| SNX2 | ACVR2B | 11279102 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| SNX6 | ACVR2B | 11279102 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| HNRNPL | ACVR2B | 25348397 | N/A | physical interaction | ComPPI |
| SYNJ2BP | ACVR2B | 11882656 14525934 15451561 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| ACVR1B | ACVR2B | 14525934 25348397 8622651 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| TGFBRAP1 | ACVR2B | 11278302 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| IGSF1 | ACVR2B | 11266516 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ACVR2B | GDF5 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| ACVR2B | INHBC | 12651901 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACVR2B | MSTN | 11459935 14525934 23829672 24234451 25348397 | physical association | experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| ACVR2B | GDF11 | 14525934 16845371 21054789 24234451 25348397 | N/A | experimental interaction detection,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| ACVR2B | BMP2 | 14525934 15064755 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| ACVR2B | INHBA | 14525934 25348397 9202237 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ACVR2B | INHBB | 14525934 25348397 9202237 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ACVR2B | ENG | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | BMP6 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | SMAD6 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | PEG10 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | GDF2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | BMP10 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | TMEM30A | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | DLK1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | PTGER3 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | LDLRAD4 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | LRRIQ1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | PCDHGA5 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | GRPR | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | CD79B | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | IZUMO1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | ZNRF4 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | MAS1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | CNGA3 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | ADGRG5 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | KIR3DL2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | MANSC1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | MRAP2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | IL17RC | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | IL4R | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | PCDHGB4 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | HEPACAM2 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | RUSF1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | GINM1 | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | IL17RB | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | RGMB | 25348397 | N/A | physical interaction | ComPPI |
| ACVR2B | FSTL1 | 20860622 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| ACVR2B | BMPR1A | 16446785 17295905 27898060 | stimulant | N/A | OmniPath |
| ACVR2B | BMPR1B | 16446785 27898060 | stimulant | N/A | OmniPath |
| ACVR2B | ACVR1 | 16446785 27898060 | stimulant | N/A | OmniPath |
| BMP2 | ACVR2B | 15064755 1644679 17295905 27898060 | stimulant | N/A | OmniPath |
| ERBIN | ACVR2B | 15123239 27898060 | N/A | N/A | OmniPath |
| ACVR2B | ACVR1B | 12364468 16446785 27898060 8612709 862265 8622651 | stimulant | N/A | OmniPath |
| ACVR2B | ACVRL1 | 16446785 27898060 | stimulant | N/A | OmniPath |
| GDF11 | ACVR2B | 12414726 16845371 21054789 27898060 | stimulant | N/A | OmniPath |
| GDF2 | ACVR2B | 15851468 27898060 | N/A | N/A | OmniPath |
| BMP7 | ACVR2B | 27898060 9748228 | stimulant | N/A | OmniPath |
| INHBA | ACVR2B | 20860622 27898060 8242742 8622651 9202237 | stimulant | N/A | OmniPath |
| NODAL | ACVR2B | 11952836 27898060 | stimulant | N/A | OmniPath |
| INHBE | ACVR2B | 22710174 27898060 | stimulant | N/A | OmniPath |
| INHBC | ACVR2B | 12651901 22710174 27898060 | stimulant | N/A | OmniPath |
| BMP3 | ACVR2B | 22074949 27898060 | N/A | N/A | OmniPath |