Gene Information gene info

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GENE：PSMB6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMB6
FullNmae proteasome 20S subunit beta 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9543
EnsembleID ENSG00000142507
Uniprot P28072

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMB6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMB6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSMB6 GO:0000502,GO:0000502,GO:0004175,GO:0004175,GO:0004298,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0005839,GO:0005839,GO:0010498,GO:0019774,GO:0019774,GO:0043161,GO:0045296,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMB6 hsa:5694 path:hsa03050 Proteasome - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05020 Prion disease - Homo sapiens (human)
PSMB6 hsa:5694 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PSMB6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A PSMB6 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PSMB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PSMB6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002367FA PSMB6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000008F0CF PSMB6 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PSMA4 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMA4 25361965 interaction type N/A PTMCode2
PSMB6 PSMA5 25361965 interaction type N/A PTMCode2
PSMA5 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMD1 25361965 interaction type N/A PTMCode2
PSMD1 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMA1 25361965 interaction type N/A PTMCode2
PSMA1 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMA7 25361965 interaction type N/A PTMCode2
PSMA7 PSMB6 25361965 interaction type N/A PTMCode2
PSMD11 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMD11 25361965 interaction type N/A PTMCode2
PSMD7 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMD7 25361965 interaction type N/A PTMCode2
PSMA3 PSMB6 25361965 interaction type N/A PTMCode2
PSMB6 PSMA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPL PSMB6 25348397 N/A physical interaction ComPPI
PSMB10 PSMB6 25348397 N/A physical interaction ComPPI
GET3 PSMB6 25348397 N/A physical interaction ComPPI
PSMC3 PSMB6 25348397 N/A physical interaction ComPPI
PSMC6 PSMB6 25348397 N/A physical interaction ComPPI
KIF5B PSMB6 25348397 N/A physical interaction ComPPI
PSMD14 PSMB6 25348397 N/A physical interaction ComPPI
TRAF6 PSMB6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSMD7 PSMB6 25348397 N/A physical interaction ComPPI
SKP1 PSMB6 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
MCM2 PSMB6 25348397 N/A physical interaction ComPPI
PSMB2 PSMB6 25348397 N/A physical interaction ComPPI
ERRFI1 PSMB6 25348397 N/A physical interaction ComPPI
EZH2 PSMB6 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
JUN PSMB6 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
USP7 PSMB6 25348397 N/A physical interaction ComPPI
PSMA3 PSMB6 25348397 N/A physical interaction ComPPI
PSMD11 PSMB6 25348397 N/A physical interaction ComPPI
UBC PSMB6 25348397 N/A physical interaction ComPPI
CDH1 PSMB6 25348397 N/A physical interaction ComPPI
PLK1 PSMB6 11205743 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PSMA1 PSMB6 12376572 24234451 25348397 25599644 29568061 association,physical association affinity chromatography technology,x-ray crystallography,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PSMA6 PSMB6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA5 PSMB6 25348397 N/A physical interaction ComPPI
PSMB9 PSMB6 25348397 N/A physical interaction ComPPI
CAPZA1 PSMB6 25348397 N/A physical interaction ComPPI
DCTN1 PSMB6 25348397 N/A physical interaction ComPPI
PSMD8 PSMB6 25348397 N/A physical interaction ComPPI
PSMB8 PSMB6 25348397 N/A physical interaction ComPPI
PSMD1 PSMB6 25348397 N/A physical interaction ComPPI
SYVN1 PSMB6 25348397 N/A physical interaction ComPPI
PSMC5 PSMB6 25348397 N/A physical interaction ComPPI
RAD23A PSMB6 25348397 N/A physical interaction ComPPI
PDCD4 PSMB6 25348397 N/A physical interaction ComPPI
SAE1 PSMB6 25348397 N/A physical interaction ComPPI
MDM2 PSMB6 22659184 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2 PSMB6 25348397 N/A physical interaction ComPPI
CUL1 PSMB6 25348397 N/A physical interaction ComPPI
TUBA1A PSMB6 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PSMC4 PSMB6 25348397 N/A physical interaction ComPPI
PSMD2 PSMB6 25348397 N/A physical interaction ComPPI
VCAM1 PSMB6 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 PSMB6 25348397 N/A physical interaction ComPPI
MID1 PSMB6 25348397 N/A physical interaction ComPPI
PRKN PSMB6 25348397 N/A physical interaction ComPPI
PSMD4 PSMB6 25348397 N/A physical interaction ComPPI
PSMB5 PSMB6 25348397 N/A physical interaction ComPPI
PSME1 PSMB6 25348397 N/A physical interaction ComPPI
PSME2 PSMB6 25348397 N/A physical interaction ComPPI
PSMC1 PSMB6 25348397 N/A physical interaction ComPPI
AMFR PSMB6 25348397 N/A physical interaction ComPPI
DERL1 PSMB6 25348397 N/A physical interaction ComPPI
ESR2 PSMB6 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
FBXO7 PSMB6 25348397 N/A physical interaction ComPPI
PSMB4 PSMB6 25348397 N/A physical interaction ComPPI
PSMB1 PSMB6 25348397 N/A physical interaction ComPPI
PSMB3 PSMB6 25348397 N/A physical interaction ComPPI
PSMB7 PSMB6 14525934 14733938 17948026 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PSMA7 PSMB6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA4 PSMB6 25348397 N/A physical interaction ComPPI
SOD1 PSMB6 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
POMP PSMB6 14525934 14733938 17948026 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PSMD5 PSMB6 25348397 N/A physical interaction ComPPI
IQCB1 PSMB6 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NDOR1 PSMB6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DCTN2 PSMB6 25348397 N/A physical interaction ComPPI
VPS16 PSMB6 25348397 N/A physical interaction ComPPI
IKBKE PSMB6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CPSF2 PSMB6 25348397 N/A physical interaction ComPPI
UCHL5 PSMB6 18922472 19615732 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
L3MBTL1 PSMB6 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
AGL PSMB6 25348397 N/A physical interaction ComPPI
ADRM1 PSMB6 25348397 N/A physical interaction ComPPI
PSMD13 PSMB6 25348397 N/A physical interaction ComPPI
PSMD12 PSMB6 25348397 N/A physical interaction ComPPI
CYLD PSMB6 25348397 N/A physical interaction ComPPI
CCND2 PSMB6 25348397 N/A physical interaction ComPPI
PSMC2 PSMB6 25348397 N/A physical interaction ComPPI
PSMD6 PSMB6 25348397 N/A physical interaction ComPPI
PSMA2 PSMB6 15887188 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NELFE PSMB6 25348397 N/A physical interaction ComPPI
PSMG2 PSMB6 25348397 N/A physical interaction ComPPI
ZCCHC8 PSMB6 25348397 N/A physical interaction ComPPI
PSMD3 PSMB6 25348397 N/A physical interaction ComPPI
HLA-B PSMB6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CAPZA2 PSMB6 25348397 N/A physical interaction ComPPI
PSMB6 PSMA8 25348397 N/A physical interaction ComPPI
PSMB6 ELP6 25348397 N/A physical interaction ComPPI
PSMB6 LRRC47 25348397 N/A physical interaction ComPPI
PSMB6 PSME4 25348397 N/A physical interaction ComPPI
PSMB6 CLEC14A 25348397 N/A physical interaction ComPPI
PSMB6 L3MBTL4 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMB6 FBL 12388758 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath

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