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GENE：BMPR1B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BMPR1B
FullNmae bone morphogenetic protein receptor type 1B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1077
EnsembleID ENSG00000138696
Uniprot O00238

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BMPR1B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMPR1B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BMPR1B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BMPR1B GO:0001502,GO:0001550,GO:0001649,GO:0001654,GO:0002063,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005886,GO:0005886,GO:0006468,GO:0006468,GO:0006954,GO:0009953,GO:0010628,GO:0021953,GO:0030166,GO:0030425,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0031290,GO:0032332,GO:0036122,GO:0042698,GO:0043025,GO:0043235,GO:0043235,GO:0045669,GO:0045944,GO:0046332,GO:0046332,GO:0046872,GO:0060041,GO:0060350,GO:0061036,GO:0071363,GO:0071773,GO:0098821,GO:1902043,GO:1902731,GO:1990712

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BMPR1B hsa:658 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
BMPR1B hsa:658 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
BMPR1B hsa:658 path:hsa04360 Axon guidance - Homo sapiens (human)
BMPR1B hsa:658 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
BMPR1B hsa:658 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
BMPR1B hsa:658 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BMPR1B SQSTM1 15761153 23180781 physical association luminescence based mammalian interactome mapping InnateDB
BMPR1B SMAD5 23331499 9766532 stimulation N/A SignaLink,SignaLink
BMPR1B SMAD1 23331499 9766532 stimulation N/A SignaLink,SignaLink
ROR2 BMPR1B 15569154 23331499 stimulation N/A SignaLink,SignaLink
ACVR2B BMPR1B 16446785 23331499 stimulation N/A SignaLink,SignaLink
BMPR2 BMPR1B 10712517 16446785 21071413 23331499 7791754 stimulation N/A SignaLink,SignaLink
BAMBI BMPR1B 10519551 23331499 stimulation N/A SignaLink
SMAD6 BMPR1B 10564272 23331499 stimulation N/A SignaLink
SMAD7 BMPR1B 10564272 23331499 stimulation N/A SignaLink
AMHR2 BMPR1B 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SNX6 BMPR1B 20005715 interaction type N/A PSP
SOCS6 BMPR1B 20005715 interaction type N/A PSP
SQSTM1 BMPR1B 20005715 interaction type N/A PSP
SQSTM1 BMPR1B 20005715 20005715 N/A N/A SignaLink
SNX6 BMPR1B 11279102 18988627 20005715 20005715 N/A N/A SignaLink
SOCS6 BMPR1B 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR BMPR1B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 BMPR1B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BMPR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 BMPR1B 24163368 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00001067D1 BMPR1B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF BMPR1B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 BMPR1B 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BMPR1B SMAD2 22135298 phosphorylation N/A PhosphoSite
BMPR1B SMAD1 22135298 phosphorylation N/A PhosphoSite
BMPR1B SMAD6 25361965 interaction type N/A PTMCode2
SMAD6 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B GDF9 25361965 interaction type N/A PTMCode2
GDF9 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMP8A 25361965 interaction type N/A PTMCode2
BMP8A BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B GDF5 25361965 interaction type N/A PTMCode2
GDF5 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMP2 25361965 interaction type N/A PTMCode2
BMP2 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMP7 25361965 interaction type N/A PTMCode2
BMP7 BMPR1B 25361965 interaction type N/A PTMCode2
BMP4 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMP4 25361965 interaction type N/A PTMCode2
SMAD7 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B SMAD7 25361965 interaction type N/A PTMCode2
BMPR1A BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMPR1A 25361965 interaction type N/A PTMCode2
BMP15 BMPR1B 25361965 interaction type N/A PTMCode2
BMPR1B BMP15 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SH3KBP1 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
OXSR1 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMP7 BMPR1B 14525934 25348397 8605097 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TRAF6 BMPR1B 14525934 18758450 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RAN BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
XIAP BMPR1B 25348397 N/A physical interaction ComPPI
PAK1 BMPR1B 25348397 N/A in vivo ComPPI
SMAD7 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SRGAP1 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMP4 BMPR1B 11282024 14525934 25348397 7811286 8702914 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RRAS2 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RASD2 BMPR1B 25348397 N/A in vivo ComPPI
UBB BMPR1B 25348397 N/A in vivo ComPPI
UBC BMPR1B 25348397 N/A in vivo ComPPI
RPS27A BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBA52 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SNX6 BMPR1B 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HNRNPL BMPR1B 25348397 N/A physical interaction ComPPI
BMPR2 BMPR1B 10712517 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PPP2CA BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SQSTM1 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAP2A BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PLEKHB1 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
AMHR2 BMPR1B 11420127 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B BMP2 14525934 15064755 19229295 24234451 25348397 7811286 9872992 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
BMPR1B BMP6 10504300 11401330 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B GDF5 16127465 19229295 24234451 25348397 N/A surface plasmon resonance,x-ray crystallography,physical interaction,in vitro ComPPI,IntAct
BMPR1B BMPR1A 10712517 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR1B GDF9 12135884 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B STAMBP 11483516 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B GDF6 14525934 25348397 9525338 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMPR1B ARHGEF6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B CDK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B CHN1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B FANCL 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B DCAF6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B KLHL1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B NKIRAS1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B CDK14 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B PPP3CC 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RAB25 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RAB38 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RAB6B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RASL12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RHEBL1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RHOD 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B RHOJ 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B SMAD6 14525934 15761153 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BMPR1B SOCS6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B STK35 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B STUB1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B TNNT1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B TTC17 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B VEPH1 25348397 N/A in vivo ComPPI
BMPR1B DCAF12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B DCAF7 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B BMP15 12419820 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR1B POMK 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B TTC27 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B UBE2Z 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B SASH3 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B UBXN1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B TSC22D1 25348397 N/A physical interaction ComPPI
BMPR1B IGSF1 25348397 N/A physical interaction ComPPI
BMPR1B SMURF1 25348397 N/A physical interaction ComPPI
BMPR1B BAMBI 25348397 N/A physical interaction ComPPI
BMPR1B APP 25348397 N/A physical interaction ComPPI
BMPR1B PEG10 25348397 N/A physical interaction ComPPI
BMPR1B USP15 25348397 N/A physical interaction ComPPI
BMPR1B EVA1C 25348397 N/A physical interaction ComPPI
BMPR1B OTUB1 25348397 N/A physical interaction ComPPI
BMPR1B TPRA1 25348397 N/A physical interaction ComPPI
BMPR1B RGMB 25348397 N/A physical interaction ComPPI
LZTR1 BMPR1B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR1B TGFBR1 11420127 14525934 N/A experimental interaction detection HPRD
BMPR1B BMPR1B 10712517 14525934 7811286 N/A experimental interaction detection HPRD
BMPR1B SMAD1 10085121 19620713 27898060 9136927 9335504 9748228 stimulant N/A OmniPath
BMPR1B SMAD5 10564272 19620713 27898060 stimulant N/A OmniPath
BMPR1B SMAD2 11043574 11879191 12145287 15134444 15731757 16121194 19120698 19540220 21532621 22393057 23166821 24244313 25727005 25872870 27898060 8980228 9136927 9346908 9346966 N/A N/A OmniPath
BMPR1B ROR2 15569154 27898060 N/A N/A OmniPath
ROR2 BMPR1B 15569154 27898060 stimulant N/A OmniPath
BMPR1B SMAD9 19620713 27898060 stimulant N/A OmniPath
BMPR1A BMPR1B 10712517 27898060 stimulant N/A OmniPath
SMAD7 BMPR1B 10564272 15761153 27898060 inhibition,stimulant N/A OmniPath
BMP2 BMPR1B 12700180 15064755 19229295 27898060 7811286 9872992 N/A N/A OmniPath
BAMBI BMPR1B 10519551 27898060 stimulant N/A OmniPath
SMAD6 BMPR1B 10564272 11483516 15761153 27898060 9436979 stimulant N/A OmniPath
BMPR2 BMPR1B 10712517 18756288 27898060 7791754 stimulant N/A OmniPath
ACVR2B BMPR1B 16446785 27898060 stimulant N/A OmniPath
NOG BMPR1B 22298955 27898060 inhibition N/A OmniPath
BMP10 BMPR1B 16049014 27898060 N/A N/A OmniPath
AMHR2 BMPR1B 11420127 14746809 27898060 stimulant N/A OmniPath
BMPR1B STAMBP 11483516 27898060 N/A N/A OmniPath

Visualization










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