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GENE：GHRL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GHRL
FullNmae ghrelin and obestatin prepropeptide
LocusType gene with protein product
Status Approved
HGNC_id HGNC:18129
EnsembleID ENSG00000157017
Uniprot Q9UBU3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GHRL apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GHRL GO:0001664,GO:0001696,GO:0001937,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0006006,GO:0007186,GO:0007186,GO:0007204,GO:0007416,GO:0008154,GO:0008343,GO:0009725,GO:0009755,GO:0016358,GO:0016525,GO:0016608,GO:0016608,GO:0016608,GO:0030252,GO:0030296,GO:0030424,GO:0031768,GO:0031768,GO:0031768,GO:0032024,GO:0032095,GO:0032100,GO:0032691,GO:0032715,GO:0032720,GO:0034774,GO:0035774,GO:0040010,GO:0040013,GO:0040018,GO:0042127,GO:0042322,GO:0043066,GO:0043400,GO:0043410,GO:0043627,GO:0046010,GO:0046676,GO:0046697,GO:0050728,GO:0050728,GO:0051216,GO:0051461,GO:0051464,GO:0051602,GO:0051965,GO:0051969,GO:0060079,GO:0060124,GO:0060124,GO:0060399,GO:0098685,GO:0098794,GO:0098978,GO:0099170,GO:0099175,GO:0120058,GO:0120162,GO:1903012,GO:1903672,GO:1904000,GO:1904179,GO:1904346,GO:1904349,GO:1905333,GO:1905564

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GHRL hsa:51738 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
GHRL hsa:51738 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
GHRL hsa:51738 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 GHRL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 GHRL 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
USF1 GHRL N/A trascriptional regulation,stimulation inferred by curator TFlink
USF2 GHRL N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MLNR GHRL 25361965 interaction type N/A PTMCode2
GHRL MLNR 25361965 interaction type N/A PTMCode2
LEP GHRL 25361965 interaction type N/A PTMCode2
GHRL LEP 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PTGIR GHRL 25348397 N/A physical interaction ComPPI
UBQLN2 GHRL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ACE2 GHRL 11815627 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GHRL GHSR 10604470 11227737 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GHRL MLNR 12606621 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GHRL AGRP 11196643 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GHRL NPY 11196643 12663466 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GHRL LEP 11196643 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GHRL TBXA2R 25348397 N/A physical interaction ComPPI
GHRL PTGER3 25348397 N/A physical interaction ComPPI
GHRL UBQLN1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GHRL GHRHR 10461027 14525934 N/A experimental interaction detection HPRD
PRKCB GHRL 18343535 27898060 N/A N/A OmniPath
GHRL GHSR 10604470 10628755 11227737 11314756 12907757 15070777 15905359 21402696 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B5424 GHRL 27087310 direct interaction,inhibition N/A NPInter

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