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GENE：BIRC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BIRC2
FullNmae baculoviral IAP repeat containing 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:590
EnsembleID ENSG00000110330
Uniprot Q13490

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BIRC2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BIRC2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BIRC2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BIRC2 apoptosis 37524969 The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. retulator signature

Go Annotation:

GeneSymbol Go id
BIRC2 GO:0000209,GO:0001666,GO:0001741,GO:0001890,GO:0003713,GO:0004842,GO:0004842,GO:0004842,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0006915,GO:0007166,GO:0007249,GO:0008270,GO:0009898,GO:0016740,GO:0031398,GO:0033209,GO:0034121,GO:0035631,GO:0038061,GO:0039535,GO:0042127,GO:0042802,GO:0042981,GO:0043027,GO:0043066,GO:0043066,GO:0043066,GO:0043123,GO:0043130,GO:0043161,GO:0044877,GO:0045088,GO:0045471,GO:0045595,GO:0045893,GO:0050727,GO:0051087,GO:0051591,GO:0051726,GO:0051726,GO:0060544,GO:0060544,GO:0060546,GO:0061630,GO:0070266,GO:0070424,GO:0098770,GO:1901222,GO:1902443,GO:1902523,GO:1902524,GO:1902527,GO:2000116,GO:2000377

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BIRC2 hsa:329 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04210 Apoptosis - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04217 Necroptosis - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04510 Focal adhesion - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
BIRC2 hsa:329 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
BIRC2 hsa:329 path:hsa05132 Salmonella infection - Homo sapiens (human)
BIRC2 hsa:329 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
BIRC2 hsa:329 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
BIRC2 hsa:329 path:hsa05200 Pathways in cancer - Homo sapiens (human)
BIRC2 hsa:329 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
BIRC2 hsa:329 path:hsa05222 Small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKB1 BIRC2 21725609 23178297 23572150 26192618 interaction type N/A ACSN
BIRC2 CASP9 16339151 23180781 25416956 9545235 physical association two hybrid,gst pull down InnateDB
BIRC2 BIRC5 15218035 23180781 physical association gst pull down InnateDB
HTRA2 BIRC2 11606597 12865429 23180781 physical association affinity chromatography technology InnateDB
GSPT1 BIRC2 12865429 23180781 ubiquitination reaction ubiquitination reaction InnateDB
BIRC2 BIRC2 14960576 15078891 18230607 18997794 20651737 23180781 26467481 ubiquitination reaction,down-regulates quantity by destabilization ubiquitination reaction,enzymatic study InnateDB,Signor
BIRC2 TRAF2 16263936 16282325 16891304 21653699 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,pull down,ubiquitin binding InnateDB
DIABLO BIRC2 11606597 16282325 23180781 ubiquitination reaction,physical association affinity chromatography technology,ubiquitination reaction InnateDB
BIRC2 CHEK1 14759516 23180781 physical association gst pull down InnateDB
BIRC2 CASP7 16339151 23180781 physical association gst pull down InnateDB
XAF1 BIRC2 17613533 23180781 physical association anti tag coimmunoprecipitation InnateDB
SH3KBP1 BIRC2 15707590 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIRC2 TNFRSF1B 23180781 8548810 9718306 physical association anti tag coimmunoprecipitation,pull down InnateDB
BIRC2 MAP3K5 17220297 23180781 physical association pull down InnateDB
MXD1 BIRC2 18082613 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,enzymatic study InnateDB
RIPK1 BIRC2 15147886 18570872 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,enzymatic study InnateDB
UBE2D3 BIRC2 12525502 12867425 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,enzymatic study InnateDB
BIRC2 UBE2D1 12525502 14960576 18230607 23180781 ubiquitination reaction,physical association anti tag coimmunoprecipitation,enzymatic study InnateDB
UBE2L3 BIRC2 12525502 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFSF14 BIRC2 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
LTBR BIRC2 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
UBE2E1 BIRC2 14960576 23180781 ubiquitination reaction enzymatic study InnateDB
FBXO7 BIRC2 16510124 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
MAP3K14 BIRC2 18022362 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNF BIRC2 12887920 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP3 BIRC2 17069460 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIRC2 XIAP 17069460 23180781 physical association anti tag coimmunoprecipitation InnateDB
UBE2N BIRC2 18570872 23180781 ubiquitination reaction enzymatic study InnateDB
RIPK2 BIRC2 19464198 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MAP4K4 BIRC2 20184394 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF3 BIRC2 20097753 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 BIRC2 20097753 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAVS BIRC2 20097753 23180781 physical association anti tag coimmunoprecipitation InnateDB
DDX58 BIRC2 21419663 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIRC2 E2F1 21653699 23180781 physical association pull down InnateDB
E2F1 BIRC2 21653699 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
CCNE1 BIRC2 21653699 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCNA2 BIRC2 21653699 23180781 physical association anti tag coimmunoprecipitation InnateDB
TANK BIRC2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TOLLIP BIRC2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF2 BIRC2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF1 BIRC2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG BIRC2 12867425 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIRC2 IKBKG 12867425 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDC42 BIRC2 23180781 24276241 physical association anti tag coimmunoprecipitation,pull down,surface plasmon resonance array InnateDB
TNFRSF1A BIRC2 23180781 23815148 physical association anti tag coimmunoprecipitation InnateDB
BCL3 BIRC2 23180781 25089799 physical association anti tag coimmunoprecipitation InnateDB
BIRC2 GFAP 23180781 25416956 physical association two hybrid InnateDB
BIRC2 NMB 23180781 25416956 physical association two hybrid InnateDB
BIRC2 BOLA1 23180781 25416956 physical association two hybrid InnateDB
BIRC2 NTAQ1 23180781 25416956 physical association two hybrid InnateDB
BIRC2 EAF2 23180781 25416956 physical association two hybrid InnateDB
BIRC2 EXOSC5 23180781 25416956 physical association two hybrid InnateDB
BIRC2 BIRC7 23180781 25416956 physical association two hybrid InnateDB
BIRC2 GCC1 23180781 25416956 physical association two hybrid InnateDB
BIRC2 TSGA10 23180781 25416956 physical association two hybrid InnateDB
BIRC2 PPM1K 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
BIRC2 RIPK2 20005715 interaction type N/A PSP
BIRC2 RAF1 20005715 interaction type N/A PSP,SignaLink
BIRC2 CASP8 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR BIRC2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BIRC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 BIRC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 BIRC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 BIRC2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 BIRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BIRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BIRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BIRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 BIRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BIRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 BIRC2 12010810 12687011 15050749 15756023 16453001 17673602 18566231 20103608 trascriptional regulation,stimulation inferred by curator TFlink
RELA BIRC2 12010810 12687011 15050749 15756023 16453001 17673602 18566231 20103608 trascriptional regulation,stimulation inferred by curator TFlink
TP53 BIRC2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000029D9F1 BIRC2 21282569 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 BIRC2 21282569 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 BIRC2 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
RIPK2 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 RIPK2 25361965 interaction type N/A PTMCode2
TNFRSF1A BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 TNFRSF1A 25361965 interaction type N/A PTMCode2
BIRC2 LTBR 25361965 interaction type N/A PTMCode2
LTBR BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 GATA5 25361965 interaction type N/A PTMCode2
GATA5 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 RIPK1 25361965 interaction type N/A PTMCode2
RIPK1 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 BCL10 25361965 interaction type N/A PTMCode2
BCL10 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 CASP7 25361965 interaction type N/A PTMCode2
CASP7 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 BIRC5 25361965 interaction type N/A PTMCode2
BIRC5 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 CASP3 25361965 interaction type N/A PTMCode2
CASP3 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 CASP9 25361965 interaction type N/A PTMCode2
CASP9 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 TRADD 25361965 interaction type N/A PTMCode2
TRADD BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 XIAP 25361965 interaction type N/A PTMCode2
XIAP BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 CASP8 25361965 interaction type N/A PTMCode2
CASP8 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 XAF1 25361965 interaction type N/A PTMCode2
XAF1 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 IKBKG 25361965 interaction type N/A PTMCode2
IKBKG BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 CD40 25361965 interaction type N/A PTMCode2
CD40 BIRC2 25361965 interaction type N/A PTMCode2
BIRC2 TNF 25361965 interaction type N/A PTMCode2
TNF BIRC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOSC5 BIRC2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GCC1 BIRC2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
AIMP2 BIRC2 25348397 N/A physical interaction ComPPI
VPS4B BIRC2 25348397 N/A physical interaction ComPPI
CDC42 BIRC2 25348397 N/A physical interaction ComPPI
SH3KBP1 BIRC2 25348397 N/A physical interaction ComPPI
BOLA1 BIRC2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TNFAIP3 BIRC2 24234451 25348397 30561431 association physical interaction,virotrap ComPPI,IntAct
TRAF6 BIRC2 25348397 N/A physical interaction ComPPI
XIAP BIRC2 25348397 N/A physical interaction ComPPI
CASP9 BIRC2 11084335 14525934 19153467 24234451 25241761 25348397 25416956 9545235 physical association anti tag coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,proximity ligation assay,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
TRIM32 BIRC2 25348397 N/A physical interaction ComPPI
UBE2D1 BIRC2 21931591 24234451 25348397 ubiquitination reaction physical interaction,enzymatic study ComPPI,IntAct
RAC1 BIRC2 22117219 24234451 25348397 association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
EGLN3 BIRC2 25348397 N/A physical interaction ComPPI
CASP3 BIRC2 11084335 14525934 24234451 25348397 9384571 physical association experimental interaction detection,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
CBLC BIRC2 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
DHX9 BIRC2 25348397 N/A physical interaction ComPPI
USP7 BIRC2 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BLK BIRC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D2 BIRC2 25348397 N/A physical interaction ComPPI
UBE2L3 BIRC2 25348397 N/A physical interaction ComPPI
RHOA BIRC2 25348397 N/A physical interaction ComPPI
GSK3B BIRC2 25348397 N/A physical interaction ComPPI
JUP BIRC2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBB BIRC2 14525934 16510124 25348397 N/A experimental interaction detection,physical interaction,bio-layer interferometry ComPPI,HPRD
UBC BIRC2 19373254 24234451 25348397 N/A pull down,physical interaction,bio-layer interferometry ComPPI,IntAct
RPS27A BIRC2 25348397 N/A physical interaction,bio-layer interferometry ComPPI
UBA52 BIRC2 25348397 N/A physical interaction,bio-layer interferometry ComPPI
UBE2N BIRC2 25348397 N/A physical interaction ComPPI
E2F1 BIRC2 25348397 N/A physical interaction ComPPI
HSP90B1 BIRC2 18239673 25348397 25361076 27898060 N/A physical interaction ComPPI,OmniPath
CASP7 BIRC2 11084335 14525934 24234451 25348397 9384571 physical association experimental interaction detection,pull down,physical interaction,enzymatic study,in vitro ComPPI,HPRD,IntAct
CASP8 BIRC2 12887920 22274400 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF3 BIRC2 23524849 24234451 25348397 30561431 association anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
TNFRSF1A BIRC2 18022363 24234451 25348397 30561431 8943045 association anti bait coimmunoprecipitation,coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
DNAJB2 BIRC2 25348397 N/A physical interaction ComPPI
NFKBIA BIRC2 25348397 N/A physical interaction ComPPI
UBR5 BIRC2 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TNF BIRC2 12887920 21822306 23815148 24234451 25348397 25911380 30561431 association anti tag coimmunoprecipitation,pull down,physical interaction,tandem affinity purification,virotrap ComPPI,IntAct
SPINK7 BIRC2 25348397 N/A physical interaction ComPPI
UBE2B BIRC2 25348397 N/A physical interaction ComPPI
RABGEF1 BIRC2 25348397 N/A physical interaction ComPPI
TRAF1 BIRC2 11907583 14525934 21988832 23524849 24234451 25348397 30561431 9384571 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,virotrap ComPPI,HPRD,IntAct
TRAF2 BIRC2 11907583 14525934 16189514 16282325 18997794 20562859 21988832 23524849 24234451 25241761 25348397 30561431 8643514 9384571 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,proximity ligation assay,two hybrid prey pooling approach,two hybrid,virotrap ComPPI,HPRD,IntAct
CLEC11A BIRC2 25348397 N/A physical interaction ComPPI
EGFR BIRC2 25348397 N/A physical interaction ComPPI
CD27 BIRC2 25348397 N/A physical interaction ComPPI
GLMN BIRC2 25348397 N/A physical interaction ComPPI
BMX BIRC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MXD1 BIRC2 25348397 N/A physical interaction ComPPI
RAF1 BIRC2 25348397 N/A physical interaction ComPPI
TSG101 BIRC2 25348397 N/A physical interaction ComPPI
CASP10 BIRC2 25348397 N/A physical interaction ComPPI
RIPK1 BIRC2 21931591 24234451 25348397 30561431 ubiquitination reaction,association,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study,virotrap ComPPI,IntAct
RIPK2 BIRC2 14525934 21931591 24234451 25348397 9642260 ubiquitination reaction,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,enzymatic study,in vivo ComPPI,HPRD,IntAct
RIPK3 BIRC2 21931591 24234451 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study ComPPI,IntAct
MAP3K14 BIRC2 18022362 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSE1L BIRC2 25348397 26668314 27898060 N/A physical interaction ComPPI,OmniPath
C1R BIRC2 25348397 N/A physical interaction ComPPI
DIABLO BIRC2 10929712 12525502 14525934 16282325 19153467 24234451 25348397 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
HTRA2 BIRC2 11583623 11604410 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
XAF1 BIRC2 25348397 N/A physical interaction ComPPI
TOLLIP BIRC2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CD40LG BIRC2 25348397 N/A physical interaction ComPPI
CASP2 BIRC2 25348397 N/A physical interaction ComPPI
UBE2D3 BIRC2 25348397 N/A physical interaction,physical interaction,bio-layer interferometry ComPPI
CD40 BIRC2 11562359 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBA1 BIRC2 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKB2 BIRC2 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUFT1 BIRC2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EAF2 BIRC2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ADAMTS4 BIRC2 25348397 N/A physical interaction ComPPI
RFC5 BIRC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM25 BIRC2 25348397 N/A physical interaction ComPPI
UBE2L6 BIRC2 25348397 N/A physical interaction ComPPI
WDR1 BIRC2 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRADD BIRC2 14525934 24234451 25348397 30561431 8943045 association experimental interaction detection,in vivo,virotrap ComPPI,HPRD,IntAct
BIRC2 LTBR 12571250 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BIRC2 UBE2J1 14525934 15861135 19690564 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro ComPPI,HPRD,IntAct
BIRC2 MAGEA11 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BIRC2 FBXO7 14525934 16510124 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BIRC2 GAS1 11906213 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
BIRC2 GSPT1 25348397 N/A physical interaction ComPPI
BIRC2 TNFSF14 25348397 N/A physical interaction ComPPI
BIRC2 UBE2W 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIRC2 BIRC5 25348397 N/A physical interaction ComPPI
BIRC2 IKBKG 12867425 14525934 23524849 24234451 25348397 30561431 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,virotrap ComPPI,HPRD,IntAct
BIRC2 TNFRSF12A 21525013 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 UBE2Q2 25348397 N/A physical interaction ComPPI
BIRC2 UBE2S 25348397 N/A physical interaction ComPPI
BIRC2 BIRC7 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC2 MAVS 25348397 N/A physical interaction ComPPI
BIRC2 RIPK4 21931591 24234451 25348397 ubiquitination reaction,physical association anti tag coimmunoprecipitation,pull down,physical interaction,enzymatic study ComPPI,IntAct
BIRC2 UBXN7 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 USP19 25348397 N/A physical interaction ComPPI
BIRC2 NOD2 25348397 N/A physical interaction ComPPI
BIRC2 BIRC3 25348397 N/A physical interaction ComPPI
BIRC2 ILF3 25348397 N/A physical interaction ComPPI
BIRC2 IGF2BP1 19893574 24704827 25348397 27898060 N/A physical interaction ComPPI,OmniPath
BIRC2 UBE2V1 25348397 N/A physical interaction ComPPI
BIRC2 PGAM5 25348397 N/A physical interaction ComPPI
BIRC2 IKBKE 25348397 N/A physical interaction ComPPI
BIRC2 RNF31 23524849 24234451 25348397 30561431 association anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
BIRC2 UBR4 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 DCAF7 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 WDR82 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 USP15 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 USP9X 23524849 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 OTUB1 23524849 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 TNFSF12 23524849 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 TRIM34 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIRC2 RNF181 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIRC2 DZIP3 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
BIRC2 PACS2 25348397 N/A physical interaction ComPPI
BIRC2 MAP3K2 25348397 N/A physical interaction ComPPI
BIRC2 MAP3K3 25348397 N/A physical interaction ComPPI
BIRC2 PCSK9 25348397 N/A physical interaction ComPPI
BIRC2 ENDOG 25348397 N/A physical interaction ComPPI
BIRC2 GFAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC2 NMB 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC2 NTAQ1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC2 TSGA10 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC2 PPM1K 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BIRC2 PRDX3 25348397 N/A physical interaction ComPPI
BIRC2 TAS2R7 25348397 N/A physical interaction ComPPI
BIRC2 FSD1 25348397 N/A physical interaction ComPPI
BIRC2 DNASE2B 25348397 N/A physical interaction ComPPI
BIRC2 UBXN1 18775313 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIRC2 ABHD17A 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BIRC2 TLR3 25348397 N/A physical interaction ComPPI
BIRC2 ULK1 25348397 N/A physical interaction ComPPI
BIRC2 TOMM20 25348397 N/A physical interaction ComPPI
BIRC2 LRRN2 25348397 N/A physical interaction ComPPI
BIRC2 LPIN3 25348397 N/A physical interaction ComPPI
BIRC2 KCTD7 25348397 N/A physical interaction ComPPI
BIRC2 TMEM9B 25348397 N/A physical interaction ComPPI
BIRC2 LYG2 25348397 N/A physical interaction ComPPI
BIRC2 C19ORF44 25348397 N/A physical interaction ComPPI
BIRC2 CCNYL1 25348397 N/A physical interaction ComPPI
BIRC2 ZFAND6 25348397 N/A physical interaction ComPPI
BIRC2 DCAF12 25348397 N/A physical interaction ComPPI
BIRC2 TAFA3 25348397 N/A physical interaction ComPPI
BIRC2 GPR107 25348397 N/A physical interaction ComPPI
BIRC2 GAP43 25348397 N/A physical interaction ComPPI
BIRC2 CYLD 25348397 N/A physical interaction ComPPI
BIRC2 LTA 23815148 24234451 25348397 association tandem affinity purification ComPPI,IntAct
BIRC2 SHARPIN 24234451 25348397 27070702 association anti bait coimmunoprecipitation ComPPI,IntAct
BIRC2 NXF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIRC2 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BIRC2 KDM1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BCL10 BIRC2 25348397 N/A physical interaction ComPPI
ILF2 BIRC2 25348397 N/A physical interaction ComPPI
TANK BIRC2 21903422 23524849 24234451 25348397 30561431 association anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
GNAZ BIRC2 25348397 N/A physical interaction ComPPI
ADRM1 BIRC2 25348397 N/A physical interaction ComPPI
CSTF2T BIRC2 25348397 N/A physical interaction ComPPI
BIRC2 BIRC2 22493164 24234451 30561431 association,physical association two hybrid array,virotrap IntAct
BIRC2 PLOD1 24234451 30561431 association virotrap IntAct
BIRC2 DIPK2A 24234451 30561431 association virotrap IntAct
BIRC2 UMAD1 24234451 30561431 association virotrap IntAct
BIRC2 RNF115 24234451 30561431 association virotrap IntAct
BIRC2 HBE1 24234451 30561431 association virotrap IntAct
BIRC2 LGR4 24234451 30561431 association virotrap IntAct
BIRC2 HAPLN3 24234451 30561431 association virotrap IntAct
BIRC2 UEVLD 24234451 30561431 association virotrap IntAct
BIRC2 TNIP2 24234451 30561431 association virotrap IntAct
BIRC2 OPTN 24234451 30561431 association virotrap IntAct
BIRC2 PLEKHB2 24234451 30561431 association virotrap IntAct
BIRC2 ULK3 24234451 30561431 association virotrap IntAct
BIRC2 TNIP1 24234451 30561431 association virotrap IntAct
BIRC2 AKR7A2 24234451 30561431 association virotrap IntAct
BIRC2 MYCBPAP 24234451 30561431 association virotrap IntAct
BIRC2 YOD1 24234451 30561431 association virotrap IntAct
BIRC2 TAX1BP1 24234451 30561431 association virotrap IntAct
BIRC2 EFNA5 24234451 30561431 association virotrap IntAct
BIRC2 CD82 24234451 30561431 association virotrap IntAct
BIRC2 UBE2V2 24234451 30561431 association virotrap IntAct
EIF2AK3 BIRC2 19029953 27898060 stimulant N/A OmniPath
BIRC2 CHEK1 14759516 27898060 N/A N/A OmniPath
TRAF2 BIRC2 10753917 11181075 11907583 15861135 16189514 16263936 16282325 16891304 18621737 18981220 18997794 19506082 19584093 19815541 20184394 20348096 20447407 20562859 20651737 21331077 21653699 21903422 21988832 23007157 23524849 24276241 25241761 25681446 25716317 27898060 8548810 8643514 8943045 9384571 stimulant N/A OmniPath
BIRC2 TRAF2 10753917 11181075 11907583 15861135 16189514 16263936 16282325 16891304 18621737 18981220 18997794 19506082 19584093 19815541 20184394 20348096 20447407 20562859 20651737 21331077 21653699 21903422 21988832 23007157 23524849 24276241 25241761 25681446 25716317 27898060 8548810 8643514 8943045 9384571 inhibition N/A OmniPath
BIRC2 RIPK2 19464198 21931591 27898060 9642260 9705938 stimulant N/A OmniPath
BIRC2 CASP7 11084335 15580265 16339151 19258326 27898060 9384571 inhibition N/A OmniPath
BIRC2 MAP3K14 18022362 19284370 20184394 25246529 27898060 inhibition N/A OmniPath
MAP3K14 BIRC2 18022362 20184394 25246529 27898060 N/A N/A OmniPath
CASP3 BIRC2 11084335 11106668 12042762 17069460 19258326 27898060 9384571 9990849 inhibition N/A OmniPath
BIRC2 CASP3 11084335 11106668 11382748 12042762 17069460 19258326 27898060 9384571 9990849 inhibition N/A OmniPath
BIRC2 CASP9 11084335 15069192 16339151 16701639 19153467 25241761 25416956 27898060 9545235 9990849 inhibition N/A OmniPath
TRAF6 BIRC2 20097753 20932475 27898060 N/A N/A OmniPath
BIRC2 TNFRSF1B 27898060 8548810 9718306 N/A N/A OmniPath
MAVS BIRC2 20097753 27898060 N/A N/A OmniPath
XIAP BIRC2 16263936 17069460 22711539 27898060 N/A N/A OmniPath
BIRC2 MAP3K5 17220297 27898060 N/A N/A OmniPath
BIRC2 IKBKG 12867425 19223549 20301198 20932475 22990857 23524849 23732909 27898060 stimulant N/A OmniPath
IKBKG BIRC2 12867425 20932475 22990857 23524849 23732909 27898060 N/A N/A OmniPath
BIRC2 UBE2D3 12525502 12867425 21113135 25383668 27898060 N/A N/A OmniPath
BIRC2 CASP2 16701639 27898060 inhibition N/A OmniPath
TNFSF14 BIRC2 12571250 27898060 N/A N/A OmniPath
TRADD BIRC2 27898060 8943045 stimulant N/A OmniPath
BIRC2 E2F1 21653699 27898060 N/A N/A OmniPath
BIRC2 LTBR 12571250 27898060 N/A N/A OmniPath
BIRC7 BIRC2 21113135 22711539 25416956 26186194 27898060 N/A N/A OmniPath
TNF BIRC2 12887920 20005846 25911380 27898060 N/A N/A OmniPath
EIF4G2 BIRC2 14960583 27898060 stimulant N/A OmniPath
BIRC3 BIRC2 23070005 27898060 stimulant N/A OmniPath
DDX58 BIRC2 21419663 27898060 N/A N/A OmniPath
BIRC5 BIRC2 15218035 15665297 25635055 27898060 N/A N/A OmniPath
BIRC2 XAF1 17613533 27898060 N/A N/A OmniPath
XAF1 BIRC2 17613533 27898060 inhibition N/A OmniPath
BIRC2 RIPK1 15147886 16603398 18570872 18621737 19284370 19854138 21113135 21931591 23972990 26612615 27898060 inhibition,stimulant N/A OmniPath
RIPK1 BIRC2 15147886 18570872 19854138 21113135 21931591 23972990 26612615 27898060 N/A N/A OmniPath
CDC42 BIRC2 24276241 27898060 N/A N/A OmniPath
BIRC2 CDC42 24276241 27898060 N/A N/A OmniPath
TNFRSF1A BIRC2 12887920 18022363 19815541 23815148 25681446 27898060 8943045 N/A N/A OmniPath
HTRA2 BIRC2 11583623 11604410 11606597 12865429 27898060 inhibition N/A OmniPath
BIRC2 HTRA2 11583623 11604410 11606597 12865429 27898060 N/A N/A OmniPath
TRAF3 BIRC2 20097753 23524849 27898060 N/A N/A OmniPath
BIRC2 DIABLO 10929712 11606597 12218061 12525502 12865429 14960576 16282325 18022362 18022363 19153467 19506082 20957035 25065467 25246529 27898060 N/A N/A OmniPath
DIABLO BIRC2 10929712 11606597 12218061 12525502 12865429 14960576 16282325 18022362 18022363 19153467 19506082 20957035 25065467 25246529 27898060 inhibition,stimulant N/A OmniPath
BIRC2 UBE2D1 12525502 14960576 18230607 19854138 21048196 21113135 21931591 22117219 24633224 24975362 25527291 27898060 N/A N/A OmniPath
BIRC2 TANK 21903422 23524849 27898060 N/A N/A OmniPath
BIRC2 MXD1 18082613 27898060 N/A N/A OmniPath
BIRC2 TRAF1 11907583 16891304 20447407 21903422 21988832 23524849 25996949 27898060 8548810 8943045 9384571 N/A N/A OmniPath
BIRC2 UBE2L3 12525502 27898060 N/A N/A OmniPath
TSGA10 BIRC2 21516116 25416956 27898060 N/A N/A OmniPath
BIRC2 FBXO7 16510124 22212761 27898060 N/A N/A OmniPath
TOLLIP BIRC2 21903422 27898060 N/A N/A OmniPath
MAP4K4 BIRC2 20184394 27898060 N/A N/A OmniPath
GSPT1 BIRC2 12865429 27898060 N/A N/A OmniPath
BIRC2 GSPT1 12865429 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009C357C BIRC2 27087310 direct interaction,inhibition N/A NPInter

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