Gene Information gene info

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GENE：SIGMAR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SIGMAR1
FullNmae sigma non-opioid intracellular receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8157
EnsembleID ENSG00000147955
Uniprot Q99720

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SIGMAR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SIGMAR1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SIGMAR1 GO:0004985,GO:0005515,GO:0005635,GO:0005637,GO:0005640,GO:0005783,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006869,GO:0007399,GO:0014069,GO:0016020,GO:0030426,GO:0031410,GO:0038003,GO:0043523,GO:0070161,GO:0070207,GO:0098839

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SIGMAR1 hsa:10280 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
SIGMAR1 hsa:10280 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 SIGMAR1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 SIGMAR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NR1I2 SIGMAR1 19129222 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SIGMAR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SIGMAR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SIGMAR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SIGMAR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SIGMAR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 SIGMAR1 22079628 trascriptional regulation,stimulation inferred by curator TFlink
MYC SIGMAR1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 SIGMAR1 N/A rna interference,inhibition experimental interaction detection miRSponge
URS0000016914 SIGMAR1 20065103 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000016914 SIGMAR1 20065103 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000324096 SIGMAR1 17699775 18668040 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS0000122ED0 SIGMAR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000002103A SIGMAR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000070B1D SIGMAR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F SIGMAR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CF056 SIGMAR1 20371350 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000B7E30 SIGMAR1 20371350 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000028DE3F SIGMAR1 20371350 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004719AB SIGMAR1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000FFE5F SIGMAR1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075A760 SIGMAR1 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000759F6E SIGMAR1 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HNRNPL SIGMAR1 25348397 N/A physical interaction ComPPI
CFTR SIGMAR1 25348397 N/A physical interaction ComPPI
PDZD11 SIGMAR1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
AK2 SIGMAR1 25348397 N/A physical interaction ComPPI
ANK2 SIGMAR1 11149946 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SIGMAR1 ITPR3 11149946 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SIGMAR1 CLN3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIGMAR1 MOV10 25348397 N/A physical interaction ComPPI
SIGMAR1 NXF1 25348397 N/A physical interaction ComPPI
SIGMAR1 ACAT1 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009B90EC SIGMAR1 27087310 direct interaction,inhibition N/A NPInter

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