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GENE：CFL2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CFL2
FullNmae cofilin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1875
EnsembleID ENSG00000165410
Uniprot Q9Y281

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CFL2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CFL2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CFL2 GO:0005515,GO:0005615,GO:0005737,GO:0007519,GO:0015629,GO:0016363,GO:0030018,GO:0030042,GO:0030042,GO:0030043,GO:0030836,GO:0031674,GO:0045214,GO:0046716,GO:0051014,GO:0051015,GO:0051015,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CFL2 hsa:1073 path:hsa04360 Axon guidance - Homo sapiens (human)
CFL2 hsa:1073 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
CFL2 hsa:1073 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
CFL2 hsa:1073 path:hsa05133 Pertussis - Homo sapiens (human)
CFL2 hsa:1073 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CFL2 IL7R 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB
CFL2 ACTG1 16189514 23180781 25416956 physical association two hybrid,pull down InnateDB
CFL2 ACTB 16189514 23180781 25416956 physical association two hybrid,pull down InnateDB

Source Target Pmid Interactiontype Methods Database
AR CFL2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 CFL2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 CFL2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 CFL2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CFL2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D CFL2 17991735 rna interference,inhibition array technology,western blot miRSponge
URS0000508C13 CFL2 N/A 15685193 rna interference,inhibition array technology miRSponge
URS0000508C13 CFL2 15685193 25416803 mrna cleavage,inhibition array technology,array technology,experimental interaction detection TarBase
URS00000ED600 CFL2 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 CFL2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000F31F4 CFL2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 CFL2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000171525 CFL2 23497265 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000045DBD CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F CFL2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F CFL2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 CFL2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001C85C7 CFL2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000023F008 CFL2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 CFL2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C CFL2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000427B68 CFL2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB CFL2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 CFL2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 CFL2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 CFL2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002004E0 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA CFL2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 CFL2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 CFL2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 CFL2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 CFL2 21572407 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00004A9320 CFL2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CFL2 SSH1 25361965 interaction type N/A PTMCode2
SSH1 CFL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MAD2L2 CFL2 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
LDHB CFL2 25348397 N/A physical interaction ComPPI
LDHA CFL2 25348397 N/A physical interaction ComPPI
ACTG1 CFL2 14525934 16189514 24234451 25348397 25910212 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CFL1 CFL2 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCM5 CFL2 25348397 N/A physical interaction ComPPI
ACTB CFL2 14525934 16189514 21516116 24234451 25348397 25910212 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PPP1CB CFL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KEAP1 CFL2 25348397 N/A physical interaction ComPPI
CD81 CFL2 25348397 N/A physical interaction ComPPI
DSTN CFL2 25348397 N/A physical interaction ComPPI
GRB2 CFL2 12577067 24234451 25348397 association pull down ComPPI,IntAct
FLNA CFL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PIR CFL2 25348397 N/A physical interaction ComPPI
ST13 CFL2 25348397 N/A physical interaction ComPPI
IQGAP1 CFL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AKR1B1 CFL2 25348397 N/A physical interaction ComPPI
MYO18A CFL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB2A CFL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PPA1 CFL2 25348397 N/A physical interaction ComPPI
STK11 CFL2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LIMK1 CFL2 12684437 14525934 25348397 8824278 9655398 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RNF4 CFL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WDR1 CFL2 25348397 N/A physical interaction ComPPI
POT1 CFL2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CFL2 SSH1 12684437 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CFL2 PAN2 25348397 N/A physical interaction ComPPI
CFL2 IGSF8 25348397 N/A physical interaction ComPPI
CFL2 CAP2 25348397 N/A physical interaction ComPPI
CFL2 LUZP4 25348397 N/A physical interaction ComPPI
CFL2 ABAT 25348397 N/A physical interaction ComPPI
CFL2 ALDH4A1 25348397 N/A physical interaction ComPPI
CFL2 CAT 25348397 N/A physical interaction ComPPI
CFL2 CRIP1 25348397 N/A physical interaction ComPPI
CFL2 MEMO1 25348397 N/A physical interaction ComPPI
CFL2 SOD1 25348397 N/A physical interaction ComPPI
CFL2 ST13P4 25348397 N/A physical interaction ComPPI
CFL2 LDHAL6A 25348397 N/A physical interaction ComPPI
CFL2 NME2 25348397 N/A physical interaction ComPPI
CFL2 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 MYO1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFL2 NANOGP8 25348397 N/A physical interaction ComPPI
CFL2 NANOG 25348397 N/A physical interaction ComPPI
CFL2 MAP3K3 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CFL2 CSRP3 24234451 24860983 25348397 N/A far western blotting ComPPI,IntAct
CFL2 TRIM7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IL7R CFL2 20167604 27898060 N/A N/A OmniPath
CFL2 ACTC1 16530787 18957424 27898060 inhibition,stimulant N/A OmniPath
LIMK1 CFL2 12684437 19413330 19651622 20068231 27898060 8079118 8824278 9655398 inhibition,stimulant N/A OmniPath
GRK2 CFL2 27898060 9677407 N/A N/A OmniPath
TESK2 CFL2 11418599 27898060 inhibition N/A OmniPath
SSH1 CFL2 12684437 27898060 inhibition N/A OmniPath
TESK1 CFL2 11418599 27898060 inhibition N/A OmniPath

Visualization










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