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GENE：IRAK4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRAK4
FullNmae interleukin 1 receptor associated kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17967
EnsembleID ENSG00000198001
Uniprot Q9NWZ3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRAK4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRAK4 GO:0000287,GO:0002224,GO:0002446,GO:0002755,GO:0004674,GO:0004674,GO:0004674,GO:0005149,GO:0005515,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0007254,GO:0008063,GO:0009986,GO:0010008,GO:0016301,GO:0016310,GO:0019221,GO:0019897,GO:0019901,GO:0034142,GO:0034162,GO:0035556,GO:0038172,GO:0043123,GO:0043123,GO:0045087,GO:0048661,GO:0070498,GO:0070498,GO:0071222,GO:0106310,GO:1990266

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRAK4 hsa:51135 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05132 Salmonella infection - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05133 Pertussis - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05135 Yersinia infection - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05142 Chagas disease - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05152 Tuberculosis - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05161 Hepatitis B - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05162 Measles - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05164 Influenza A - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IRAK4 hsa:51135 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRAK4 IL1R1 11274345 12609980 12620219 12682231 14660645 16878026 17704786 18977329 19161412 23180781 23681101 23811849 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IRAK4 IL1RAP 11274345 12620219 12682231 14660645 16878026 17704786 18977329 19161412 23681101 23811849 26192618 interaction type N/A ACSN
MYD88 IRAK4 10679398 11274345 11592085 11960013 11964313 12150927 12620219 12682231 12860405 12907458 14504095 14607900 14660645 14662834 15084582 15099563 15749884 15749903 15802534 15905496 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17486091 17704786 18633355 18977329 19161412 19167362 20485341 20547845 20966070 21372296 21826665 23180781 23508573 23681101 23811849 26192618 26885855 27048821 27066895 9469432 9743347 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,pull down,x-ray crystallography ACSN,InnateDB
IRAK4 CD14 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 21903422 23180781 23508573 23681101 23811849 26192618 9743347 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IRAK4 LY96 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 TIRAP 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 IL18 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IRAK4 IL18R1 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IRAK4 IL18RAP 10679398 11274345 11592085 12620219 12682231 14504095 14660645 14662834 15099563 15802534 16878026 17704786 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type N/A ACSN
IRAK4 IRAK1 10679398 11274345 11592085 11960013 12538665 12620219 12682231 12738796 12860405 14504095 14660645 14662834 15084582 15099563 15125833 15802534 16252010 16878026 17276401 17704786 17948050 18264787 18758450 18855897 18922473 18977329 19161412 21614932 21903422 23070005 23180781 23681101 23811849 26192618 26885855 27048821 27066895 9469432 interaction type,phosphorylation reaction,physical association anti tag coimmunoprecipitation,two hybrid,in-gel kinase assay ACSN,InnateDB
IRAK4 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 PYCARD 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 CXCL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 VEGFA 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
PELI2 IRAK4 12860405 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 IL1RL1 12538665 15084582 16286016 23180781 physical association anti tag coimmunoprecipitation InnateDB
NCF1 IRAK4 17217339 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 TLR5 17138965 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 PTPRC 16574867 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 IRAK4 11960013 17141195 21220427 23180781 24567333 26467481 phosphorylation reaction,up-regulates activity in-gel kinase assay,protein kinase assay InnateDB,Signor
IRAK4 TRAF6 11960013 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 TBPL1 16169070 23180781 physical association two hybrid InnateDB
IRAK4 PELI1 17997719 23180781 phosphorylation reaction protein kinase assay InnateDB
IRAK4 TLR4 21220427 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IRAK4 20485341 23180781 24973222 physical association pull down,x-ray crystallography,Split renilla luciferase complementation InnateDB
IRAK4 TNFRSF13B 20676093 23180781 physical association pull down InnateDB
YWHAQ IRAK4 21827211 23180781 physical association pull down InnateDB
AGER IRAK4 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
TLR4 IRAK4 21829704 23180781 physical association anti tag coimmunoprecipitation InnateDB
TIRAP IRAK4 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK4 UNC5CL 22158417 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK1 IRAK4 15905496 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL1R1 IRAK4 15905496 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SMARCA4 IRAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IRAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IRAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IRAK4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F31F4 IRAK4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 IRAK4 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00001AFC71 IRAK4 23264652 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000028BB8 IRAK4 23264652 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000009A9A2 IRAK4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 IRAK4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C IRAK4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE IRAK4 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 IRAK4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A IRAK4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 IRAK4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C4762 IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075D814 IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075CC78 IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B83FE IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 IRAK4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 IRAK4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 IRAK4 25416803 26821827 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
IRAK4 PELI1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IRAK4 IRAK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IRAK4 IRAK4 22135298 phosphorylation N/A PhosphoSite
IRAK4 NCF1 22135298 phosphorylation N/A PhosphoSite
PELI3 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 PELI3 25361965 interaction type N/A PTMCode2
IRAK2 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 IRAK2 25361965 interaction type N/A PTMCode2
IL1RL1 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 IL1RL1 25361965 interaction type N/A PTMCode2
TRAF6 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 TRAF6 25361965 interaction type N/A PTMCode2
PELI1 IRAK4 25361965 interaction type N/A PTMCode2
IRAK1 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 IRAK4 11960013 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TIRAP IRAK4 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AGER IRAK4 21829704 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
EIF4EBP1 IRAK4 25348397 N/A physical interaction ComPPI
IRAK1 IRAK4 11960013 12860405 14525934 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
H1-4 IRAK4 25348397 N/A physical interaction ComPPI
MBP IRAK4 25348397 N/A physical interaction ComPPI
H1-5 IRAK4 25348397 N/A physical interaction ComPPI
IRAK2 IRAK4 20485341 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,molecular sieving,pull down,x-ray crystallography,physical interaction ComPPI,IntAct
TLR4 IRAK4 21829704 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYD88 IRAK4 11960013 12860405 14525934 24234451 25348397 25910212 26871637 physical association two hybrid,experimental interaction detection,light scattering,molecular sieving,nuclear magnetic resonance,pull down,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid ComPPI,HPRD,IntAct
IRAK3 IRAK4 25348397 N/A physical interaction ComPPI
IRAK4 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK4 PELI2 12860405 14525934 17675297 24234451 25348397 phosphorylation reaction,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vivo ComPPI,HPRD,IntAct
IRAK4 PELI3 14525934 17675297 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRAK4 H1-1 25348397 N/A physical interaction ComPPI
IRAK4 H1-2 25348397 N/A physical interaction ComPPI
IRAK4 H1-3 25348397 N/A physical interaction ComPPI
IRAK4 H1-6 25348397 N/A physical interaction ComPPI
IRAK4 IL1R1 25348397 N/A physical interaction ComPPI
IRAK4 IL1RL1 16286016 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK4 TNFRSF13B 20676093 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
IRAK4 SASH1 25348397 N/A physical interaction ComPPI
IRAK4 ARNT 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK4 IKBKG 25348397 N/A physical interaction ComPPI
IRAK4 KIF11 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK4 VSIG8 25348397 N/A physical interaction ComPPI
IRAK4 ZNF597 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IRAK4 TRIM7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TBPL1 IRAK4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
IL36RN IRAK4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PELI1 IRAK4 12496252 14525934 17675297 19264966 24234451 25348397 phosphorylation reaction,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,phosphorylation reaction,physical interaction,protein kinase assay ComPPI,HPRD,IntAct
IRAK4 IRAK4 24234451 24316379 N/A molecular sieving IntAct
IRAK4 TRAF6 11960013 23381138 27898060 stimulant N/A OmniPath
IRAK4 TLR4 17635639 21220427 21829704 27898060 N/A N/A OmniPath
IRAK4 TLR5 17138965 27898060 N/A N/A OmniPath
MYD88 IRAK4 11960013 12150927 12297423 12538665 12860405 15084582 15905496 16410796 17486091 17548806 18221795 19167362 19592493 19679662 20485341 20966070 21179087 22011580 24735611 25416956 27898060 stimulant N/A OmniPath
IRAK4 MYD88 11960013 12150927 12538665 12860405 15084582 15905496 17486091 17548806 18221795 19167362 19592493 19679662 20485341 20966070 21179087 22011580 24735611 25416956 27898060 N/A N/A OmniPath
IL1R1 IRAK4 12609980 15292196 15905496 17507369 27898060 N/A N/A OmniPath
IRAK4 TIRAP 18221795 21903422 27898060 N/A N/A OmniPath
IRAK1 IRAK4 11960013 12538665 12860405 14751757 15084582 15292196 15905496 16024789 16951688 17276401 17785851 18221795 18524972 19166926 21903422 24735611 27898060 N/A N/A OmniPath
IRAK4 IRAK1 11960013 11976320 12538665 12860405 14751757 15084582 15292196 15905496 16024789 16951688 17276401 17785851 18221795 18252867 18524972 19166926 19775907 21903422 24735611 27898060 stimulant N/A OmniPath
IL1RL1 IRAK4 12538665 15084582 16286016 27898060 N/A N/A OmniPath
IRAK4 IL1RL1 12538665 15084582 16286016 27898060 N/A N/A OmniPath
IRAK4 PELI2 12860405 17675297 27898060 stimulant N/A OmniPath
TNFRSF13B IRAK4 20676093 27898060 N/A N/A OmniPath
UNC5CL IRAK4 22158417 27898060 N/A N/A OmniPath
IRAK4 NCF1 11535139 17217339 27898060 stimulant N/A OmniPath
IRAK3 IRAK4 25290089 27898060 inhibition N/A OmniPath
PELI1 IRAK4 12496252 16951688 17675297 17997719 19264966 21204785 27898060 N/A N/A OmniPath
IRAK4 PELI1 12496252 16951688 17675297 17997719 19264966 21204785 27898060 N/A N/A OmniPath
IRAK4 IRAK2 20485341 21903422 24973222 27898060 N/A N/A OmniPath
IRAK4 TBPL1 16169070 27898060 N/A N/A OmniPath

Visualization










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