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GENE：PRKAR2A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKAR2A
FullNmae protein kinase cAMP-dependent type II regulatory subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9391
EnsembleID ENSG00000114302
Uniprot P13861

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKAR2A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKAR2A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKAR2A GO:0004862,GO:0004862,GO:0005515,GO:0005737,GO:0005813,GO:0005829,GO:0005829,GO:0005886,GO:0005925,GO:0005930,GO:0005952,GO:0005952,GO:0008603,GO:0008603,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031625,GO:0032991,GO:0034236,GO:0034236,GO:0035556,GO:0044853,GO:0070062,GO:0097546,GO:2000480,GO:2000480

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKAR2A hsa:5576 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUZ12 PRKAR2A 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
PRKAR2A RET 20005715 interaction type N/A PSP
PRKAR2A SCTR 20005715 interaction type N/A PSP
PRKAR2A GSK3B 20005715 interaction type N/A PSP
PRKAR2A AKAP13 20005715 interaction type N/A PSP
PRKAR2A GNA13 20005715 interaction type N/A PSP
PRKAR2A RET 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PRKAR2A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PRKAR2A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRKAR2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRKAR2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKAR2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKAR2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PRKAR2A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F4AC3 PRKAR2A 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 PRKAR2A 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000324096 PRKAR2A 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00004E008F PRKAR2A 23446348 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000239117 PRKAR2A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000475586 PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001310DE PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000081D1E PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A PRKAR2A 20371350 21572407 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000D2680 PRKAR2A 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000035AC91 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001DA458 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 PRKAR2A 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 PRKAR2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD PRKAR2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 PRKAR2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018E6CD PRKAR2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 PRKAR2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PRKAR2A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCDA3 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000048F59D PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002075FA PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000017CCCB PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000B989F PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000299AD8 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001481F9 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002CEB74 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00005F9738 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000047A8F PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000214763 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000E7139 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075BDAA PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075D860 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000049FAE8 PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000EC1BE PRKAR2A 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPRE1 PRKAR2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLL1 PRKAR2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP43 PRKAR2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IMPDH2 PRKAR2A 25348397 N/A physical interaction ComPPI
TOMM22 PRKAR2A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKAR2B PRKAR2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP PRKAR2A 25348397 N/A physical interaction ComPPI
PPP1CB PRKAR2A 10209101 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 PRKAR2A 14525934 14966294 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
KEAP1 PRKAR2A 25348397 N/A physical interaction ComPPI
PRKACB PRKAR2A 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PDE4A PRKAR2A 25348397 N/A physical interaction ComPPI
JUN PRKAR2A 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD3 PRKAR2A 14525934 14966294 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN22 PRKAR2A 25348397 N/A physical interaction ComPPI
PRKACA PRKAR2A 23455922 24234451 24605759 25348397 phosphorylation reaction,association physical interaction,protein kinase assay,tandem affinity purification ComPPI,IntAct
AKAP13 PRKAR2A 12672969 14525934 1618839 25348397 7929081 N/A experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD
RYR2 PRKAR2A 10830164 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GSK3B PRKAR2A 25348397 N/A physical interaction ComPPI
DLD PRKAR2A 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CAV1 PRKAR2A 19706440 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK1E PRKAR2A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KCNQ1 PRKAR2A 25348397 N/A physical interaction ComPPI
WASF1 PRKAR2A 10970852 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP2 PRKAR2A 2147685 25348397 2561973 2701845 27898060 N/A biophysical,physical interaction,in vivo ComPPI,OmniPath
PRKAR2A SCTR 14525934 25348397 9506976 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKAR2A SEMG2 12399526 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKAR2A PRKX 10026146 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKAR2A AKAP14 12475942 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKAR2A AKAP1 10764601 14525934 16642035 24083380 24234451 25348397 26496610 9065479 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
PRKAR2A CBFA2T3 11823486 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PRKAR2A AKAP3 10319321 11278869 11696326 24234451 25348397 27898060 physical association two hybrid,pull down,physical interaction,in vitro ComPPI,IntAct,OmniPath
PRKAR2A AKAP6 10413680 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKAR2A AKAP10 14525934 25348397 9326583 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKAR2A AKAP11 10209101 12147701 12672969 14525934 25348397 27898060 8621616 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PRKAR2A AKAP12 11316952 14525934 16642035 24234451 25348397 physical association experimental interaction detection,filter binding,physical interaction,in vitro ComPPI,HPRD,IntAct
PRKAR2A NBEA 11102458 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKAR2A RAB32 12186851 12672969 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
PRKAR2A AKAP2 12672969 14525934 25348397 27898060 9497389 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PRKAR2A MYCBPAP 12151104 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PRKAR2A AKAP7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PRKAR2A CFTR 10799517 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
PRKAR2A RET 11886862 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKAR2A EZR 12080047 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKAR2A RUNX1T1 11593431 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PRKAR2A AKAP7 25348397 N/A physical interaction ComPPI
PRKAR2A AKAP5 11557526 12672969 14525934 16642035 1860836 22343722 24234451 25348397 26496610 27898060 association,physical association anti tag coimmunoprecipitation,biophysical,experimental interaction detection,filter binding,fluorescent resonance energy transfer,molecular sieving,physical interaction ComPPI,HPRD,IntAct,OmniPath
PRKAR2A AKAP9 25348397 N/A physical interaction ComPPI
PRKAR2A ARFGEF2 12571360 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PRKAR2A AKAP8 10601332 14525934 24234451 25348397 9473338 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,far western blotting,physical interaction,fluorescence microscopy ComPPI,HPRD,IntAct
PRKAR2A GNA13 25348397 N/A physical interaction ComPPI
PRKAR2A AKAP4 25348397 N/A physical interaction ComPPI
PRKAR2A PJA2 24083380 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2A ELAVL1 25348397 N/A physical interaction ComPPI
PRKAR2A CIRBP 25348397 N/A physical interaction ComPPI
PRKAR2A GCH1 25348397 N/A physical interaction ComPPI
PRKAR2A CSRP1 25348397 N/A physical interaction ComPPI
PRKAR2A GPS1 25348397 N/A physical interaction ComPPI
PRKAR2A SUZ12 25348397 N/A physical interaction ComPPI
PRKAR2A ABCE1 25348397 N/A physical interaction ComPPI
PRKAR2A SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PRKAR2A XPO1 25348397 N/A physical interaction ComPPI
PRKAR2A CLTC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2A PCNT 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2A OFD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2A SEC16A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2A SFN 11414803 24234451 25348397 27898060 physical association two hybrid ComPPI,IntAct,OmniPath
PRKAR2A MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAR2A CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAR2A CCND3 16721056 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAR2A CCNE1 16721056 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRKAR2A TOMM20 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKAR2A LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MAPK6 PRKAR2A 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
KPNA6 PRKAR2A 25348397 N/A physical interaction ComPPI
PRKAR2A PRKAR2A 11823486 12672969 14525934 6293815 N/A experimental interaction detection HPRD
PRKAR2A IFNGR2 24234451 27621415 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy IntAct
PPP3CA PRKAR2A 27898060 9660947 N/A N/A OmniPath
PRKCA PRKAR2A 11263724 27898060 N/A N/A OmniPath
PPP3CB PRKAR2A 27898060 9660947 N/A N/A OmniPath
PPP3CC PRKAR2A 27898060 9660947 N/A N/A OmniPath
PDE4DIP PRKAR2A 21569246 27898060 stimulant N/A OmniPath

Visualization










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