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GENE：PRKACG

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKACG
FullNmae protein kinase cAMP-activated catalytic subunit gamma
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9382
EnsembleID ENSG00000165059
Uniprot P22612

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKACG apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKACG GO:0003091,GO:0004674,GO:0004679,GO:0004691,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0005952,GO:0007283,GO:0008584,GO:0010737,GO:0016310,GO:0018105,GO:0034237,GO:0034380,GO:0097546,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKACG hsa:5568 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04530 Tight junction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04540 Gap junction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04611 Platelet activation - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04713 Circadian entrainment - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04714 Thermogenesis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04720 Long-term potentiation - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04727 GABAergic synapse - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04740 Olfactory transduction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04742 Taste transduction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04911 Insulin secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04916 Melanogenesis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04924 Renin secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04934 Cushing syndrome - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04970 Salivary secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa04976 Bile secretion - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05012 Parkinson disease - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05020 Prion disease - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05030 Cocaine addiction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05032 Morphine addiction - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05034 Alcoholism - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05110 Vibrio cholerae infection - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05146 Amoebiasis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PRKACG hsa:5568 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRKACG PREX1 16301320 23109003 inhibition N/A SignaLink
CAMP PRKACG 15539636 16460834 23109003 7935349 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PRKACG 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 PRKACG 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRKACG 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PRKACG 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRKACG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PRKACG 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RYR2 PRKACG 25361965 interaction type N/A PTMCode2
PRKACG RYR2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PDE4DIP PRKACG 25348397 N/A physical interaction ComPPI
HSPA8 PRKACG 25348397 N/A physical interaction ComPPI
PRKAR2B PRKACG 25348397 N/A physical interaction ComPPI
TNP2 PRKACG 25348397 N/A physical interaction ComPPI
PRKACB PRKACG 25348397 N/A physical interaction ComPPI
PRKACA PRKACG 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RYR2 PRKACG 25348397 N/A physical interaction ComPPI
PRKAR1A PRKACG 25348397 N/A physical interaction ComPPI
UBB PRKACG 25348397 N/A physical interaction ComPPI
AKAP14 PRKACG 25348397 N/A physical interaction ComPPI
AKAP1 PRKACG 25348397 N/A physical interaction ComPPI
AKAP7 PRKACG 25348397 N/A physical interaction ComPPI
PRKAR1B PRKACG 25348397 N/A physical interaction ComPPI
VAPB PRKACG 25348397 N/A physical interaction ComPPI
CDK17 PRKACG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CETP PRKACG 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HMGN1 PRKACG 25348397 N/A physical interaction ComPPI
AKAP9 PRKACG 25348397 N/A physical interaction ComPPI
MLF1 PRKACG 25348397 N/A physical interaction ComPPI
AKAP5 PRKACG 25348397 N/A physical interaction ComPPI
AKAP7 PRKACG 25348397 N/A physical interaction ComPPI
PRKACG GPR161 25348397 N/A physical interaction ComPPI
PRKACG ENDOG 25348397 N/A physical interaction ComPPI
PRKACG TTC9C 25348397 N/A physical interaction ComPPI
PRKACG MRPS15 25348397 N/A physical interaction ComPPI
TNP1 PRKACG 25348397 N/A physical interaction ComPPI
PRKACG NOS3 11729179 27898060 stimulant N/A OmniPath
PRKACG KCNQ4 15660259 27898060 stimulant N/A OmniPath
PRKACG BAD 10230396 10949026 27898060 inhibition,stimulant N/A OmniPath
PRKACG MYBPC3 20151718 27898060 stimulant N/A OmniPath

Visualization










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