GENE：NFAT5
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NFAT5 |
| FullNmae | nuclear factor of activated T cells 5 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7774 |
| EnsembleID | ENSG00000102908 |
| Uniprot | O94916 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NFAT5 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NFAT5 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NFAT5 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NFAT5 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NFAT5 | GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001816,GO:0003682,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006366,GO:0006974,GO:0007165,GO:0008134,GO:0010628,GO:0033173,GO:0045944,GO:0062176,GO:0070884,GO:0071345,GO:0071474,GO:1901224,GO:1904996,GO:1990837 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NFAT5 | TNF | 11485737 16027109 23180781 | physical association | anti tag coimmunoprecipitation,DNase I footprinting | InnateDB |
| NFAT5 | S100A4 | 21289293 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFAT5 | RELA | 20685965 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| PTPN6 | NFAT5 | 20351292 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFAT5 | PLCG1 | 20080774 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFAT5 | AR | 20080774 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| CYP3A7 | NFAT5 | 17600221 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| SLC5A3 | NFAT5 | 17600221 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFAT5 | CYP2E1 | 17440116 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| NFAT5 | PARP1 | 17148781 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HSP90AA1 | NFAT5 | 17148781 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| NFAT5 | AKR1B1 | 16644704 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NFAT5 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | NFAT5 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | NFAT5 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | NFAT5 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SOX17 | NFAT5 | 24407731 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | NFAT5 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000001EB3 | NFAT5 | 19524507 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS0000001EB3 | NFAT5 | 19524507 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000237AF9 | NFAT5 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | NFAT5 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000070B1D | NFAT5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000013DD8 | NFAT5 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002075FA | NFAT5 | 20371350 21572407 22473208 23446348 23592263 23622248 25416803 27292025 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS0000044FD7 | NFAT5 | 24039954 25416803 | mrna cleavage,inhibition | array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000065D58 | NFAT5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000005CF5F | NFAT5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | NFAT5 | 22473208 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001DE669 | NFAT5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | NFAT5 | 20371350 21572407 22473208 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | NFAT5 | 20371350 21572407 22473208 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000302909 | NFAT5 | 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | NFAT5 | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | NFAT5 | 20371350 21572407 22473208 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | NFAT5 | 20371350 21572407 22473208 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | NFAT5 | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | NFAT5 | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | NFAT5 | 20371350 21572407 22473208 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000049FAE8 | NFAT5 | 23313552 23592263 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045B99E | NFAT5 | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B0F6 | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | NFAT5 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | NFAT5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E628F | NFAT5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000243FF1 | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | NFAT5 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075994C | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | NFAT5 | 20371350 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | NFAT5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000338542 | NFAT5 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | NFAT5 | 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000060AABB | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | NFAT5 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00005F1B8C | NFAT5 | 23592263 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000016914 | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D860 | NFAT5 | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000034B6F5 | NFAT5 | 20371350 21572407 23446348 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002394F5 | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002578DA | NFAT5 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075CC78 | NFAT5 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | NFAT5 | 23824327 24906430 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | NFAT5 | 23313552 23824327 24906430 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFBE3 | NFAT5 | 25416803 25515214 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS000005D4F5 | NFAT5 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C403E | NFAT5 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077DDE | NFAT5 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | NFAT5 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004D84DB | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB0E | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001496AE | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C4B1 | NFAT5 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ABL1 | NFAT5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CDK5 | NFAT5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CSNK1A1 | NFAT5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| ATM | NFAT5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| CSNK1A1L | NFAT5 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PTPN6 | NFAT5 | 25348397 | N/A | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,dephosphorylation reaction,physical interaction,protein phosphatase assay | ComPPI |
| DDX17 | NFAT5 | 22266867 24234451 25348397 | physical association | anti tag coimmunoprecipitation,proximity ligation assay | ComPPI,IntAct |
| JUN | NFAT5 | 25348397 | N/A | physical interaction | ComPPI |
| PRKACA | NFAT5 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | NFAT5 | 25348397 | N/A | physical interaction | ComPPI |
| DDX5 | NFAT5 | 22266867 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,proximity ligation assay | ComPPI,IntAct |
| TRIM25 | NFAT5 | 25348397 | N/A | physical interaction | ComPPI |
| TBC1D4 | NFAT5 | 12421765 14525934 24234451 25348397 | physical association | two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| NFAT5 | FOXP3 | 14525934 15790681 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NFAT5 | FOS | 25348397 | N/A | physical interaction | ComPPI |
| NFAT5 | PLCG1 | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| NFAT5 | NFAT5 | 11780147 14525934 | N/A | experimental interaction detection | HPRD |
| NFAT5 | RELA | 20685965 27898060 | N/A | N/A | OmniPath |
| CDK5 | NFAT5 | 21209322 27898060 | stimulant | N/A | OmniPath |
| NFAT5 | SLC5A3 | 15522988 27898060 | stimulant | N/A | OmniPath |
| ATM | NFAT5 | 15173573 27898060 | stimulant | N/A | OmniPath |
| NFAT5 | AKR1B1 | 15522988 18056707 27898060 | stimulant | N/A | OmniPath |
| FOS | NFAT5 | 18056707 27898060 | stimulant | N/A | OmniPath |
| PTPN6 | NFAT5 | 20351292 27898060 | inhibition | N/A | OmniPath |
| NFAT5 | SLC6A12 | 15522988 27898060 | stimulant | N/A | OmniPath |
| NFAT5 | GBGT1 | 18056707 27898060 | stimulant | N/A | OmniPath |
| ABL1 | NFAT5 | 20080774 27898060 | N/A | N/A | OmniPath |
| CDK1 | NFAT5 | 21209322 27898060 | stimulant | N/A | OmniPath |
| JUN | NFAT5 | 18056707 27898060 | stimulant | N/A | OmniPath |
| CSNK1A1L | NFAT5 | 18411282 27898060 | N/A | N/A | OmniPath |