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GENE：IRAK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRAK2
FullNmae interleukin 1 receptor associated kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6113
EnsembleID ENSG00000134070
Uniprot O43187

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRAK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRAK2 GO:0001959,GO:0002755,GO:0004672,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0005886,GO:0006468,GO:0006954,GO:0007249,GO:0008063,GO:0010008,GO:0031663,GO:0032088,GO:0034142,GO:0035556,GO:0042803,GO:0046982,GO:0051092,GO:0051092,GO:0060090,GO:0070498,GO:0070498,GO:0070555,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRAK2 hsa:3656 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
IRAK2 hsa:3656 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CD14 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 21903422 23180781 23508573 23681101 23811849 26192618 9743347 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
LY96 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP IRAK2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 21903422 23180781 23508573 23681101 23811849 26192618 9743347 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IRAK2 IL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 PYCARD 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 IL6 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 CXCL10 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 IRAK1 10383454 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16024789 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 21903422 23180781 23508573 23681101 23811849 24973222 26192618 9743347 interaction type,phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay,Split renilla luciferase complementation ACSN,InnateDB
IRAK2 FLT3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 CCL2 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 VEGFA 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 TIMP1 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 TRAF6 10383454 12659850 21903422 23180781 24973222 9374458 physical association anti tag coimmunoprecipitation,gst pull down,Split renilla luciferase complementation InnateDB
IRAK2 MYD88 10383454 12659850 20485341 23180781 9374458 physical association anti tag coimmunoprecipitation,gst pull down,pull down,x-ray crystallography InnateDB
IRAK2 IL1R1 12659850 23180781 9374458 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
IRAK2 TIRAP 11544529 23180781 physical association anti tag coimmunoprecipitation InnateDB
HRAS IRAK2 11744690 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IL1RAP 12659850 23180781 physical association gst pull down InnateDB
IRAK2 AKT1 12906710 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 CTCF 15670593 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 TMED7 12721283 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 TLR3 17878161 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 PSEN2 18996842 23180781 physical association anti tag coimmunoprecipitation InnateDB
PSEN1 IRAK2 18996842 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IRAK4 20485341 23180781 24973222 physical association pull down,x-ray crystallography,Split renilla luciferase complementation InnateDB
IRAK1 IRAK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IQSEC1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 CDC37 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IQCB1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 ARAF 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 SNRNP200 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 ZC3H12C 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 STT3A 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 SESTD1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 YTHDF1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 TARDBP 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 BAG3 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 ZC3H12A 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 COQ8A 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 FASTKD5 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK3 IRAK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
SARM1 IRAK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TOLLIP IRAK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 IRAK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK2 IRAK2 23180781 24973222 physical association Split renilla luciferase complementation InnateDB
IL1R1 IRAK2 23331499 9374458 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR IRAK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA1 IRAK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IRAK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C IRAK2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IRAK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IRAK2 15670593 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IRAK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2B IRAK2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001EFBE3 IRAK2 20124483 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 IRAK2 18927107 19596990 20124483 25416803 25889446 28077577 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr miR2Disease,TarBase
URS0000237AF9 IRAK2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000568FF8 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000027352D IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006F90B IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003D4175 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043C1C3 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000030F801 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C0099 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021202F IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC4BD IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000021D08 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075A608 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075CC78 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000355E82 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D814 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001012BC IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000209F04 IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041FA2C IRAK2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IRAK2 TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 IRAK2 25361965 interaction type N/A PTMCode2
IRAK2 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 IRAK2 25361965 interaction type N/A PTMCode2
IRAK2 PELI1 25361965 interaction type N/A PTMCode2
PELI1 IRAK2 25361965 interaction type N/A PTMCode2
IRAK2 TIRAP 25361965 interaction type N/A PTMCode2
TIRAP IRAK2 25361965 interaction type N/A PTMCode2
IRAK2 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK2 25361965 interaction type N/A PTMCode2
IRAK2 IRAK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BAG3 IRAK2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFAIP3 IRAK2 25348397 N/A physical interaction ComPPI
TRAF6 IRAK2 10383454 14525934 21903422 21988832 24234451 25348397 9374458 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vivo ComPPI,HPRD,IntAct
ZC3H12A IRAK2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AB1 IRAK2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
HRAS IRAK2 11744690 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARAF IRAK2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD2 IRAK2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSP90AA1 IRAK2 25348397 N/A physical interaction ComPPI
TIRAP IRAK2 11544529 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
TUBA4A IRAK2 25348397 N/A physical interaction ComPPI
IRAK1 IRAK2 10383454 14525934 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RBBP4 IRAK2 21903422 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
IRAK2 MYD88 10383454 12659850 14525934 24234451 25348397 9374458 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IRAK2 IRAK3 10383454 14525934 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
IRAK2 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK2 SMURF1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRAK2 TLR4 14525934 25348397 9625770 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRAK2 PELI2 14525934 17675297 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRAK2 PELI3 14525934 17675297 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRAK2 IL1R1 12659850 14525934 25348397 9374458 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IRAK2 TLR3 25348397 N/A physical interaction ComPPI
IRAK2 MME 17342744 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 IQSEC1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 YTHDF1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 ZC3H12C 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 COQ8A 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 CDC37 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 IQCB1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 SNRNP200 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 STT3A 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 TARDBP 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 IRAK4 20485341 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,molecular sieving,pull down,x-ray crystallography,physical interaction ComPPI,IntAct
IRAK2 SARM1 25348397 N/A physical interaction ComPPI
IRAK2 TOLLIP 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 PSEN1 25348397 N/A physical interaction ComPPI
IRAK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
IRAK2 TNFSF9 25348397 N/A physical interaction ComPPI
IRAK2 N4BP2L2 25348397 N/A physical interaction ComPPI
IRAK2 TRIM25 25348397 N/A physical interaction ComPPI
IRAK2 CCDC47 21903422 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
IRAK2 YTHDF2 21903422 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FASTKD5 IRAK2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PELI1 IRAK2 14525934 17675297 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SESTD1 IRAK2 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IRAK2 IRAK2 10383454 14525934 24234451 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
HRAS IRAK2 11744690 27898060 N/A N/A OmniPath
TRAF6 IRAK2 10383454 12659850 17878161 21903422 21988832 24973222 26250868 27898060 9374458 N/A N/A OmniPath
IRAK2 AKT1 12906710 27898060 N/A N/A OmniPath
MYD88 IRAK2 10383454 12659850 20485341 22011580 27898060 9374458 N/A N/A OmniPath
IRAK2 IL1R1 12659850 27898060 9374458 N/A N/A OmniPath
IL1R1 IRAK2 12659850 27898060 9374458 stimulant N/A OmniPath
TLR3 IRAK2 17878161 27898060 N/A N/A OmniPath
IRAK2 TLR3 17878161 27898060 N/A N/A OmniPath
IRAK2 TIRAP 11544529 21903422 27898060 N/A N/A OmniPath
TIRAP IRAK2 11544529 21903422 27898060 N/A N/A OmniPath
IRAK2 IRAK1 10383454 12138165 16024789 21903422 24973222 27898060 N/A N/A OmniPath
IRAK1 IRAK2 10383454 12138165 16024789 21903422 24973222 27898060 stimulant N/A OmniPath
IRAK4 IRAK2 20485341 21903422 24973222 27898060 N/A N/A OmniPath
IRAK2 TOLLIP 21903422 27898060 N/A N/A OmniPath
TOLLIP IRAK2 21903422 27898060 N/A N/A OmniPath

Visualization










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