GENE：LTBP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | LTBP1 |
| FullNmae | latent transforming growth factor beta binding protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6714 |
| EnsembleID | ENSG00000049323 |
| Uniprot | Q14766 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| LTBP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| LTBP1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| LTBP1 | GO:0001527,GO:0005024,GO:0005201,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005788,GO:0007178,GO:0031012,GO:0031012,GO:0032991,GO:0035583,GO:0035583,GO:0050431,GO:0050436,GO:0050436,GO:0060090,GO:0062023,GO:0062023,GO:1901388 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| LTBP1 | hsa:4052 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TGFB1 | LTBP1 | 10025398 10544215 11133108 11766992 14557817 15548370 15611103 16139227 16474430 16710477 17934056 18342983 18423981 18802007 19010789 19109155 19741094 19854168 19909365 19920116 20519943 20535745 20644162 21278795 21883891 21900405 21909923 22703233 23620508 25732845 26192618 26552706 26711338 7594497 8570922 9314552 9931372 | interaction type | N/A | ACSN |
| MMP2 | LTBP1 | 21900405 23691193 24376839 26192618 | interaction type | N/A | ACSN |
| MMP9 | LTBP1 | 21900405 26192618 | interaction type | N/A | ACSN |
| THBS1 | LTBP1 | 10657674 11982756 14568985 14996710 21900405 22943793 26192618 8349738 | interaction type | N/A | ACSN |
| MMP13 | LTBP1 | 21900405 26192618 | interaction type | N/A | ACSN |
| MMP14 | LTBP1 | 21900405 21909923 23691193 24376839 26192618 | interaction type | N/A | ACSN |
| LTBP1 | CEBPD | 21072181 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| LTBP1 | LTBP1 | 26467481 8432736 | bind,up-regulates activity | N/A | Signor |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | LTBP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | LTBP1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | LTBP1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | LTBP1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | LTBP1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | LTBP1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | LTBP1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | LTBP1 | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | LTBP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | LTBP1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | LTBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT3 | LTBP1 | 22814105 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ZNF408 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| TGFB1 | LTBP1 | 12429738 24234451 25348397 | colocalization | transmission electron microscopy,light scattering,molecular sieving,pull down,physical interaction | ComPPI,IntAct |
| MMP3 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGB5 | LTBP1 | 12358597 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| KBTBD7 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| TGM2 | LTBP1 | 14525934 25348397 27898060 9060478 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| CDH5 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| PCOLCE | LTBP1 | 24117177 24234451 25348397 | N/A | surface plasmon resonance array | ComPPI,IntAct |
| PTPN4 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| BCHE | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| MMP10 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| CACNA1A | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| MED23 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| EFEMP1 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| FBN1 | LTBP1 | 12429738 24234451 25348397 | colocalization | in vitro,in vivo,confocal microscopy | ComPPI,IntAct |
| SMURF1 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| PCDHA4 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP3 | LTBP1 | 12962157 14525934 25348397 27898060 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,OmniPath |
| CSN1S1 | LTBP1 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | FBN2 | 12429738 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| LTBP1 | ATN1 | 14525934 16713569 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| LTBP1 | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | HLA-DPA1 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | GINM1 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | ZFP41 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | IGFBP5 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | ALKBH3 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | ZNF131 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | KLRG2 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | PCDHB11 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | PCDH20 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | PCDH12 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | VWCE | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | PCDHGB4 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | PCDHGA5 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | DEFA5 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | ODAPH | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | PCDHA12 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | LOXL3 | 25348397 | N/A | physical interaction | ComPPI |
| LTBP1 | FAM20C | 22582013 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| LTBP1 | LTBP1 | 10930463 14525934 8617200 | N/A | experimental interaction detection | HPRD |
| LTBP1 | FN1 | 14525934 27898060 8756760 | N/A | experimental interaction detection | HPRD,OmniPath |
| LTBP1 | TGFB1 | 10930463 12429738 21677751 27898060 8432736 | inhibition,stimulant | N/A | OmniPath |