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GENE：PPP2R1B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP2R1B
FullNmae protein phosphatase 2 scaffold subunit Abeta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9303
EnsembleID ENSG00000137713
Uniprot P30154

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP2R1B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP2R1B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP2R1B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PPP2R1B GO:0000159,GO:0005515,GO:0005737,GO:0006470,GO:0019888,GO:0045121,GO:0060561,GO:0070062,GO:2001241

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP2R1B hsa:5519 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04110 Cell cycle - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04530 Tight junction - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa04730 Long-term depression - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa05142 Chagas disease - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa05160 Hepatitis C - Homo sapiens (human)
PPP2R1B hsa:5519 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PPP2R1B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PPP2R1B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PPP2R1B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PPP2R1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PPP2R1B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000BE495 PPP2R1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000034B6F5 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00006097A6 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002367FA PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000053B1E8 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EE123 PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000034979B PPP2R1B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 PPP2R1B 21572407 22927820 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000134ADC PPP2R1B 22927820 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PPP2R1B 21572407 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 PPP2R1B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 PPP2R1B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E PPP2R1B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 PPP2R1B 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PPP2CA PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2CA 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R1A 25361965 interaction type N/A PTMCode2
PPP2R1A PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPM1A 25361965 interaction type N/A PTMCode2
PPM1A PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R5C 25361965 interaction type N/A PTMCode2
PPP2R5C PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R2B 25361965 interaction type N/A PTMCode2
PPP2R2B PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R5E 25361965 interaction type N/A PTMCode2
PPP2R5E PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PDCD10 25361965 interaction type N/A PTMCode2
PDCD10 PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B HSPD1 25361965 interaction type N/A PTMCode2
HSPD1 PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B STK3 25361965 interaction type N/A PTMCode2
STK3 PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R5D 25361965 interaction type N/A PTMCode2
PPP2R5D PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R5B PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R5B 25361965 interaction type N/A PTMCode2
SIK2 PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B SIK2 25361965 interaction type N/A PTMCode2
PPP2R5A PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B PPP2R5A 25361965 interaction type N/A PTMCode2
RALA PPP2R1B 25361965 interaction type N/A PTMCode2
PPP2R1B RALA 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 PPP2R1B 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BHLHE40 PPP2R1B 23555304 24234451 25348397 physical association two hybrid ComPPI,IntAct
RPN1 PPP2R1B 25348397 N/A physical interaction ComPPI
CEP43 PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
TNFAIP3 PPP2R1B 25348397 N/A physical interaction ComPPI
PPP2R1A PPP2R1B 18782753 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP62 PPP2R1B 24234451 25348397 25435324 N/A pull down,physical interaction ComPPI,IntAct
SET PPP2R1B 14525934 25348397 9353299 N/A experimental interaction detection,in vitro ComPPI,HPRD
STRN PPP2R1B 14525934 17540176 24234451 24366813 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PDCD10 PPP2R1B 18782753 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SIK2 PPP2R1B 16306228 24234451 25348397 association tandem affinity purification ComPPI,IntAct
ZNF219 PPP2R1B 25348397 N/A physical interaction ComPPI
POLA1 PPP2R1B 25348397 N/A physical interaction ComPPI
RAB7A PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PRKAA1 PPP2R1B 25348397 N/A physical interaction ComPPI
STRN3 PPP2R1B 14525934 17540176 18782753 24234451 24366813 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CAV1 PPP2R1B 25348397 N/A physical interaction ComPPI
PPP2R5A PPP2R1B 17540176 18782753 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PRDX1 PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2CB PPP2R1B 19156129 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RALA PPP2R1B 14525934 17540176 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HNRNPL PPP2R1B 25348397 N/A physical interaction ComPPI
CFTR PPP2R1B 14525934 15936019 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
PPP2R5C PPP2R1B 11929880 14525934 16456541 17540176 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2CA PPP2R1B 14525934 17540176 18715871 18782753 19156129 24234451 25348397 28330616 8392071 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,chromatography technology,pull down,physical interaction,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
RELA PPP2R1B 11591705 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPP2R5E PPP2R1B 14525934 17540176 23555304 24234451 25348397 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CLTC PPP2R1B 25348397 N/A physical interaction ComPPI
PDCD4 PPP2R1B 25348397 N/A physical interaction ComPPI
EGFR PPP2R1B 25348397 N/A physical interaction ComPPI
FGFR1 PPP2R1B 25348397 N/A physical interaction ComPPI
RAB11A PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
JAK2 PPP2R1B 11440634 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PPP2R2A PPP2R1B 1328247 14525934 17540176 24234451 25348397 26496610 28330616 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,proximity-dependent biotin identification ComPPI,HPRD,IntAct
PPP2R3B PPP2R1B 25348397 N/A physical interaction ComPPI
TRIM25 PPP2R1B 25348397 N/A physical interaction ComPPI
NCBP1 PPP2R1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WNT3A PPP2R1B 25348397 N/A physical interaction ComPPI
STK24 PPP2R1B 18782753 23455922 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CRY2 PPP2R1B 25348397 N/A physical interaction ComPPI
PPP2R3A PPP2R1B 24234451 25348397 8392071 physical association chromatography technology,physical interaction ComPPI,IntAct
FOXO3 PPP2R1B 25348397 N/A physical interaction ComPPI
STRN4 PPP2R1B 18782753 24234451 25348397 association tandem affinity purification ComPPI,IntAct
CDK4 PPP2R1B 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MCM3 PPP2R1B 17540176 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,in vivo ComPPI,IntAct
MAP3K3 PPP2R1B 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PPP2R1B PRDX2 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2R1B PARK7 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2R1B RAB18 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2R1B HSPD1 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
PPP2R1B EEF2 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2R1B ANXA5 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PPP2R1B MOB4 18782753 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPP2R1B STK25 18782753 23455922 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PPP2R1B PPP2R2C 18782753 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PPP2R1B PPP2R5B 25348397 N/A physical interaction ComPPI
PPP2R1B ZRANB1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B INTS1 25348397 N/A physical interaction ComPPI
PPP2R1B INTS3 25348397 N/A physical interaction ComPPI
PPP2R1B INTS5 25348397 N/A physical interaction ComPPI
PPP2R1B INTS6 25348397 N/A physical interaction ComPPI
PPP2R1B PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PPP2R1B PPP2R2D 19156129 24234451 25348397 28330616 association anti tag coimmunoprecipitation,pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PPP2R1B CDK1 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PPP2R1B HDAC1 14525934 17540176 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
PPP2R1B STAT3 25348397 N/A physical interaction ComPPI
PPP2R1B FBXW4 25348397 N/A physical interaction ComPPI
PPP2R1B DNAAF5 25348397 N/A physical interaction ComPPI
PPP2R1B ARPC1A 25348397 N/A physical interaction ComPPI
PPP2R1B ARPC5 25348397 N/A physical interaction ComPPI
PPP2R1B IKBKG 25348397 N/A physical interaction ComPPI
PPP2R1B UNC5B 25348397 N/A physical interaction ComPPI
PPP2R1B DAPK1 21172653 24234451 25348397 colocalization cosedimentation through density gradient,physical interaction ComPPI,IntAct
PPP2R1B CSNK2B 23555304 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP2R1B DELEC1 25348397 N/A physical interaction ComPPI
PPP2R1B RORC 23555304 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP2R1B CLOCK 25348397 N/A physical interaction ComPPI
PPP2R1B CRY1 25348397 N/A physical interaction ComPPI
PPP2R1B BHLHE41 25348397 N/A physical interaction ComPPI
PPP2R1B FBXW11 25348397 N/A physical interaction ComPPI
PPP2R1B FOXS1 25348397 N/A physical interaction ComPPI
PPP2R1B SERTAD4 25348397 N/A physical interaction ComPPI
PPP2R1B FAM43A 25348397 N/A physical interaction ComPPI
PPP2R1B SGO2 14525934 16541025 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction,two hybrid ComPPI,HPRD,IntAct
PPP2R1B ZNF114 25348397 N/A physical interaction ComPPI
PPP2R1B IER2 25348397 N/A physical interaction ComPPI
PPP2R1B ACADM 25348397 N/A physical interaction ComPPI
PPP2R1B SLC25A3 25348397 N/A physical interaction ComPPI
PPP2R1B PPP4R1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B FGFR1OP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B SIKE1 18782753 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B DCAF1 25348397 N/A physical interaction ComPPI
PPP2R1B FOXD4 25348397 N/A physical interaction ComPPI
PPP2R1B TBCCD1 25348397 N/A physical interaction ComPPI
PPP2R1B CDCA4 25348397 N/A physical interaction ComPPI
PPP2R1B PRR14 25348397 N/A physical interaction ComPPI
PPP2R1B PTPDC1 25348397 N/A physical interaction ComPPI
PPP2R1B ZNF550 25348397 N/A physical interaction ComPPI
PPP2R1B TRIM35 25348397 N/A physical interaction ComPPI
PPP2R1B TRAF3IP3 18782753 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2R1B NCAPD3 25348397 N/A physical interaction ComPPI
PPP2R1B TAFA3 25348397 N/A physical interaction ComPPI
PPP2R1B ZNF331 25348397 N/A physical interaction ComPPI
PPP2R1B ZNF785 25348397 N/A physical interaction ComPPI
PPP2R1B MAX 25348397 N/A physical interaction ComPPI
PPP2R1B EP400 25348397 N/A physical interaction ComPPI
PPP2R1B DOCK5 19156129 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R1B STRIP1 18782753 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R1B CTTNBP2 18782753 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R1B TNIP3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R1B ULK2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R1B ESPL1 24234451 24781523 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PPP2R5D PPP2R1B 14525934 16541025 17540176 23555304 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
USP53 PPP2R1B 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLMAP PPP2R1B 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTTNBP2NL PPP2R1B 18782753 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SGO1 PPP2R1B 14525934 16541024 16541025 N/A experimental interaction detection,two hybrid HPRD
PPP2R1B BSG 14525934 17540176 N/A experimental interaction detection HPRD
PPP2R1B PPP2R1B 23555304 24234451 physical association two hybrid IntAct
PPP2R1B RALA 17540176 27898060 N/A N/A OmniPath
PPP2R1B PPP2CA 12370081 17540176 18715871 18782753 19114990 19156129 22939629 26344197 26496610 27898060 stimulant N/A OmniPath

Visualization










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