Gene Information gene info

GENE:PSMB4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMB4
FullNmae proteasome 20S subunit beta 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9541
EnsembleID ENSG00000159377
Uniprot P28070

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMB4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMB4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSMB4 GO:0000502,GO:0000502,GO:0001530,GO:0002862,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005839,GO:0005839,GO:0010498,GO:0019774,GO:0019774,GO:0036064,GO:0043161,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMB4 hsa:5692 path:hsa03050 Proteasome - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05020 Prion disease - Homo sapiens (human)
PSMB4 hsa:5692 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PSMB4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PSMB4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 PSMB4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PSMB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PSMB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PSMB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PSMB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PSMB4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000C85B2 PSMB4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PSMA4 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMA4 25361965 interaction type N/A PTMCode2
PSMC1 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMC1 25361965 interaction type N/A PTMCode2
PSMA5 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMA5 25361965 interaction type N/A PTMCode2
PSMD11 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMD11 25361965 interaction type N/A PTMCode2
PSMB4 PSMC3 25361965 interaction type N/A PTMCode2
PSMC3 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMA1 25361965 interaction type N/A PTMCode2
PSMA1 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMB10 25361965 interaction type N/A PTMCode2
PSMB10 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMA7 25361965 interaction type N/A PTMCode2
PSMA7 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMB4 25361965 interaction type N/A PTMCode2
PSMD7 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMD7 25361965 interaction type N/A PTMCode2
PSMA3 PSMB4 25361965 interaction type N/A PTMCode2
PSMB4 PSMA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPL PSMB4 25348397 N/A physical interaction ComPPI
PSMB4 SMAD1 11438941 11571290 12097147 14525934 15231748 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PSMB4 PLK1 11205743 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSMB4 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB4 OAZ1 25348397 N/A physical interaction ComPPI
PSMB4 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB4 MYC 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PSMB4 PSMA2 15887188 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB4 PCK1 25348397 N/A physical interaction ComPPI
PSMB4 RAD23A 25348397 N/A physical interaction ComPPI
PSMB4 SEM1 25348397 N/A physical interaction ComPPI
PSMB4 SEM1 25348397 N/A physical interaction ComPPI
PSMB4 PSMA4 25348397 N/A physical interaction ComPPI
PSMB4 PRPF19 25348397 N/A physical interaction ComPPI
PSMB4 NUB1 25348397 N/A physical interaction ComPPI
PSMB4 UBD 25348397 N/A physical interaction ComPPI
PSMB4 PSMC5 25348397 N/A physical interaction ComPPI
PSMB4 USP7 25348397 N/A physical interaction ComPPI
PSMB4 CUL1 25348397 N/A physical interaction ComPPI
PSMB4 UCHL5 18922472 19490896 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB4 PSMB3 25348397 N/A physical interaction ComPPI
PSMB4 PSMB5 17948026 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMB4 PSMB7 17948026 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMB4 PSMB8 25348397 N/A physical interaction ComPPI
PSMB4 POMP 17948026 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMB4 PSMB10 25348397 N/A physical interaction ComPPI
PSMB4 CRBN 23026050 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMB4 AKT1 25348397 N/A physical interaction ComPPI
PSMB4 APP 25348397 N/A physical interaction ComPPI
PSMB4 PSMA1 12376572 24234451 25348397 25599644 29568061 association,physical association affinity chromatography technology,pull down,x-ray crystallography,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PSMB4 PSMA3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMB4 PSMA5 25348397 N/A physical interaction ComPPI
PSMB4 PSMA6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB4 PSMA7 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB4 PSMB1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 PSMB2 25348397 N/A physical interaction ComPPI
PSMB4 PSMB6 25348397 N/A physical interaction ComPPI
PSMB4 PSMC3 25348397 N/A physical interaction ComPPI
PSMB4 PSMD7 25348397 N/A physical interaction ComPPI
PSMB4 PSMD1 25348397 N/A physical interaction ComPPI
PSMB4 PSMD2 25348397 N/A physical interaction ComPPI
PSMB4 PSMD3 25348397 N/A physical interaction ComPPI
PSMB4 PSMD8 25348397 N/A physical interaction ComPPI
PSMB4 PSMD4 25348397 N/A physical interaction ComPPI
PSMB4 PSMD6 25348397 N/A physical interaction ComPPI
PSMB4 PSMD14 25348397 N/A physical interaction ComPPI
PSMB4 PSMD13 25348397 N/A physical interaction ComPPI
PSMB4 PSMD11 25348397 N/A physical interaction ComPPI
PSMB4 PSME3 25348397 N/A physical interaction ComPPI
PSMB4 PSMD12 25348397 N/A physical interaction ComPPI
PSMB4 PSMC2 25348397 N/A physical interaction ComPPI
PSMB4 PSMD5 25348397 N/A physical interaction ComPPI
PSMB4 PSMA8 25348397 N/A physical interaction ComPPI
PSMB4 EEF1A1 25348397 N/A physical interaction ComPPI
PSMB4 EEF1A1P5 25348397 N/A physical interaction ComPPI
PSMB4 USP9X 25348397 N/A physical interaction ComPPI
PSMB4 SYAP1 25348397 N/A physical interaction ComPPI
PSMB4 YBX1 25348397 N/A physical interaction ComPPI
PSMB4 SULT1A3 25348397 N/A physical interaction ComPPI
PSMB4 IQCB1 25348397 N/A physical interaction ComPPI
PSMB4 CFTR 25348397 N/A physical interaction ComPPI
PSMB4 PRKN 25348397 N/A physical interaction ComPPI
PSMB4 BAG3 25348397 N/A physical interaction ComPPI
PSMB4 PRKCA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PSMB4 HNRNPA2B1 25348397 N/A physical interaction ComPPI
PSMB4 DDB2 25348397 N/A physical interaction ComPPI
PSMB4 EPB41L1 25348397 N/A physical interaction ComPPI
PSMB4 KIF5B 25348397 N/A physical interaction ComPPI
PSMB4 RPP38 25348397 N/A physical interaction ComPPI
PSMB4 PSMG3 25348397 N/A physical interaction ComPPI
PSMB4 PSMD9 25348397 N/A physical interaction ComPPI
PSMB4 HNRNPA1 25348397 N/A physical interaction ComPPI
PSMB4 FSD2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMB4 AMFR 25348397 N/A physical interaction ComPPI
PSMB4 SYVN1 25348397 N/A physical interaction ComPPI
PSMB4 PSME4 25348397 N/A physical interaction ComPPI
PSMB4 PSME1 25348397 N/A physical interaction ComPPI
PSMB4 FBXO7 25348397 N/A physical interaction ComPPI
PSMB4 PSMG2 25348397 N/A physical interaction ComPPI
PSMB4 PSME2 25348397 N/A physical interaction ComPPI
PSMB4 PSMF1 25348397 N/A physical interaction ComPPI
PSMB4 PSMB9 25348397 N/A physical interaction ComPPI
PSMB4 CPSF2 25348397 N/A physical interaction ComPPI
PSMB4 NELFE 25348397 N/A physical interaction ComPPI
PSMB4 PEX19 25348397 N/A physical interaction ComPPI
PSMB4 ADRM1 25348397 N/A physical interaction ComPPI
PSMB4 CLIC4 25348397 N/A physical interaction ComPPI
PSMB4 PSMC1 25348397 N/A physical interaction ComPPI
PSMB4 PSMC4 25348397 N/A physical interaction ComPPI
PSMB4 PSMC6 25348397 N/A physical interaction ComPPI
PSMB4 U2AF2 25348397 N/A physical interaction ComPPI
PSMB4 UBA2 25348397 N/A physical interaction ComPPI
PSMB4 HERC2 25348397 N/A physical interaction ComPPI
PSMB4 HERC2P3 25348397 N/A physical interaction ComPPI
PSMB4 FOXJ3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PSMB4 FOXP3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
PSMB4 MID1 25348397 N/A physical interaction ComPPI
PSMB4 PSMG1 25348397 N/A physical interaction ComPPI
PSMB4 YAP1 25348397 N/A physical interaction ComPPI
PSMB4 TRAF6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 NME2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 L3MBTL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMB4 SKP1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMB4 MAPK6 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMB4 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 BCL6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 KANK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 C1ORF109 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 MYOZ3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 PKN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 GABARAPL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 GCA 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 HGS 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 HEMK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 SPG21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 DTX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 SMN1 25348397 N/A two hybrid ComPPI
PSMB4 TFAP2D 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 PROP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 SOHLH1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 TEKT5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 P4HA3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 PFDN5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 KRTAP19-5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB4 RAB11A 24234451 25348397 29568061 association pull down ComPPI,IntAct
PSMB4 SHLD3 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
DAG1 PSMB4 24234451 association cross-linking study IntAct

Visualization