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GENE：IRAK3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRAK3
FullNmae interleukin 1 receptor associated kinase 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17020
EnsembleID ENSG00000090376
Uniprot Q9Y616

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRAK3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRAK3 GO:0000287,GO:0001819,GO:0001960,GO:0002755,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005886,GO:0006468,GO:0008063,GO:0009615,GO:0010933,GO:0010936,GO:0019221,GO:0019901,GO:0032088,GO:0032494,GO:0032496,GO:0032695,GO:0032695,GO:0032695,GO:0032715,GO:0032715,GO:0032720,GO:0032720,GO:0034122,GO:0035556,GO:0042177,GO:0042803,GO:0042803,GO:0043242,GO:0043244,GO:0043330,GO:0043407,GO:0043407,GO:0045824,GO:0046982,GO:0051092,GO:0051092,GO:0070498,GO:0070498,GO:0070555,GO:0071222

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRAK3 hsa:11213 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRAK3 TRAF6 12150927 12620219 14660645 18264787 26192618 interaction type N/A ACSN
MYD88 IRAK3 10383454 12150927 23180781 physical association anti tag coimmunoprecipitation InnateDB
TRAF6 IRAK3 10383454 21098228 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK3 IRAK1 10383454 21903422 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
TMED7 IRAK3 12721283 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP6 IRAK3 21098228 23180781 protein cleavage,physical association anti tag coimmunoprecipitation,protease assay InnateDB
IRAK3 IRAK2 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK3 JUN 22154382 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 IRAK3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 IRAK3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IRAK3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 IRAK3 20852130 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000338542 IRAK3 20852130 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000075C1E1 IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C IRAK3 20371350 21572407 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 IRAK3 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E IRAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004E78D3 IRAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000365675 IRAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A IRAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075ABF4 IRAK3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IRAK3 TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 IRAK3 25361965 interaction type N/A PTMCode2
IRAK3 IRAK1 25361965 interaction type N/A PTMCode2
IRAK1 IRAK3 25361965 interaction type N/A PTMCode2
IRAK3 MYD88 25361965 interaction type N/A PTMCode2
MYD88 IRAK3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 IRAK3 10383454 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
HSP90AB1 IRAK3 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
NONO IRAK3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AA1 IRAK3 25348397 N/A physical interaction ComPPI
COPB1 IRAK3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK1 IRAK3 10383454 14525934 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
LDB1 IRAK3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IRAK2 IRAK3 10383454 14525934 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
MYD88 IRAK3 10383454 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
IRAK3 TICAM2 12721283 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK3 IRAK4 25348397 N/A physical interaction ComPPI
IRAK3 HSP90AA2P 25348397 N/A physical interaction ComPPI
IRAK3 ATP6V0B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK3 ECM1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK3 NSA2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IRAK3 ADH1B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IRAK3 CD14 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
IRAK3 FOLR1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK3 NTRK3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IRAK3 CDCA5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRAK3 STAT3 24234451 25348397 27150039 physical association proximity ligation assay ComPPI,IntAct
HOXB7 IRAK3 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
IRAK3 IRAK3 10383454 14525934 24234451 physical association anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
KRT8 IRAK3 24234451 30021884 physical association cross-linking study IntAct
KRT18 IRAK3 24234451 30021884 physical association cross-linking study IntAct
TRAF6 IRAK3 10383454 21098228 27898060 N/A N/A OmniPath
IRAK3 TRAF6 10383454 21098228 27898060 stimulant N/A OmniPath
MYD88 IRAK3 10383454 12150927 27898060 N/A N/A OmniPath
IRAK3 MYD88 10383454 12150927 27898060 N/A N/A OmniPath
IRAK1 IRAK3 10383454 12138165 19166926 21903422 27898060 stimulant N/A OmniPath
IRAK3 IRAK1 10383454 12138165 19166926 21903422 27898060 inhibition N/A OmniPath
IRAK3 IRAK4 25290089 27898060 inhibition N/A OmniPath

Visualization










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