GENE：MAPK11
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAPK11 |
| FullNmae | mitogen-activated protein kinase 11 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6873 |
| EnsembleID | ENSG00000185386 |
| Uniprot | Q15759 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAPK11 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK11 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MAPK11 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAPK11 | GO:0001649,GO:0004674,GO:0004674,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010628,GO:0016310,GO:0031098,GO:0032735,GO:0035556,GO:0038066,GO:0038066,GO:0051149,GO:0051403,GO:0060038,GO:0060044,GO:0060348,GO:0071347,GO:0071493,GO:0090398,GO:0098586,GO:0106310 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAPK11 | hsa:5600 | path:hsa01522 | Endocrine resistance - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04148 | Efferocytosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04714 | Thermogenesis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04932 | Non-alcoholic fatty liver disease - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05133 | Pertussis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05140 | Leishmaniasis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05142 | Chagas disease - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05161 | Hepatitis B - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05208 | Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
| MAPK11 | hsa:5600 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TAB1 | MAPK11 | 16648477 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK11 | DYRK1B | 12384504 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK11 | MAP2K4 | 12788955 23180781 | physical association | gst pull down | InnateDB |
| MAPK11 | ATF2 | 15192015 23180781 | phosphorylation reaction | protein kinase assay | InnateDB |
| MAPK11 | DUSP1 | 11359773 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK11 | DUSP10 | 11359773 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| MAPK11 | MAPKAPK5 | 23180781 23331499 9628874 | phosphorylation reaction,stimulation | in-gel kinase assay | InnateDB,SignaLink |
| MAPK11 | RPS6KA5 | 21071413 23331499 9687510 | stimulation | N/A | SignaLink,SignaLink |
| MAP2K3 | MAPK11 | 11242034 23331499 | stimulation | N/A | SignaLink,SignaLink |
| MAP2K6 | MAPK11 | 11242034 23331499 | stimulation | N/A | SignaLink,SignaLink |
| MAPK11 | SMAD2 | 20820849 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | MAPK11 | 19296470 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00003380CC | MAPK11 | 19296470 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPK11 | SOD2 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | MAPK11 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | EEF2K | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| MAPK11 | HSF1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | RPTOR | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | E2F1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | EGFR | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | MAPKAPK5 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| MAPK11 | CDC25B | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | HNF4A | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | ATF7 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | GYS1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | PRKCE | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | EWSR1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | CCND3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | NR3C1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK11 | ESR1 | 25361965 | interaction type | N/A | PTMCode2 |
| ESR1 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | ELK4 | 25361965 | interaction type | N/A | PTMCode2 |
| ELK4 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | DUSP10 | 25361965 | interaction type | N/A | PTMCode2 |
| DUSP10 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | JUN | 25361965 | interaction type | N/A | PTMCode2 |
| JUN | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| ATF2 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | ATF2 | 25361965 | interaction type | N/A | PTMCode2 |
| TP53 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | TP53 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPKAPK5 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | BCL2 | 25361965 | interaction type | N/A | PTMCode2 |
| ELK1 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | ELK1 | 25361965 | interaction type | N/A | PTMCode2 |
| DUSP16 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | DUSP16 | 25361965 | interaction type | N/A | PTMCode2 |
| HDAC3 | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| MAPK11 | HDAC3 | 25361965 | interaction type | N/A | PTMCode2 |
| EEF2K | MAPK11 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SOCS3 | MAPK11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| BAG3 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| CCND1 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| ZNHIT1 | MAPK11 | 17380123 24234451 25348397 | phosphorylation reaction,physical association | two hybrid,pull down,protein kinase assay | ComPPI,IntAct |
| SP1 | MAPK11 | 14676314 24234451 25348397 | association | coimmunoprecipitation | ComPPI,IntAct |
| JUN | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| HDAC3 | MAPK11 | 25348397 | N/A | two hybrid,physical interaction,in vitro,in vivo | ComPPI |
| MAPKAPK5 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| MAPK14 | MAPK11 | 21900206 23602568 24234451 25348397 | association,physical association | two hybrid,physical interaction,tandem affinity purification | ComPPI,IntAct |
| PKN1 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| MAPT | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| PTPN7 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| ELK1 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| PTPRR | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| DUSP16 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| RPS6KA5 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| MBP | MAPK11 | 25348397 | N/A | physical interaction,in vitro | ComPPI |
| POLR3D | MAPK11 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MTREX | MAPK11 | 14676314 24234451 25348397 | association | coimmunoprecipitation | ComPPI,IntAct |
| SH2D1A | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| MAPKAPK2 | MAPK11 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| BCL2 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| HTRA2 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| CUL7 | MAPK11 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ELK4 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| MAPKAPK3 | MAPK11 | 21988832 23602568 24234451 25348397 | association,physical association | two hybrid,physical interaction,tandem affinity purification | ComPPI,IntAct |
| DUSP2 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| EEF2K | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| DUSP10 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| ESR2 | MAPK11 | 25348397 | N/A | in vitro | ComPPI |
| PML | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| KRT1 | MAPK11 | 14676314 24234451 25348397 | association | coimmunoprecipitation | ComPPI,IntAct |
| NOXA1 | MAPK11 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK11 | C9ORF78 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MAPK11 | CPNE6 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MAPK11 | APP | 25348397 | N/A | physical interaction | ComPPI |
| MAPK11 | OBSL1 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK11 | MKNK1 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK11 | DUSP9 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK11 | VARS1 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK11 | CCDC8 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK11 | ARHGAP12 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK11 | HDAC1 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK11 | PPM1G | 25348397 | N/A | physical interaction | ComPPI |
| MAPK11 | TAB1 | 24234451 25241761 25348397 | physical association | physical interaction,proximity ligation assay | ComPPI,IntAct |
| MAPK11 | MYB | 14676314 24234451 25348397 | association | coimmunoprecipitation | ComPPI,IntAct |
| MAPK11 | TP53 | 17254968 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| ATF2 | MAPK11 | 17254968 24234451 25348397 | phosphorylation reaction | physical interaction,protein kinase assay,in vitro | ComPPI,IntAct |
| MAPK11 | EGFR | 16932740 27898060 | inhibition | N/A | OmniPath |
| MAPK11 | TCF3 | 15719023 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | RPS6KA5 | 27898060 9687510 | stimulant | N/A | OmniPath |
| MAPK11 | KRT8 | 11788583 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | CCND3 | 15252116 15326477 16331257 22885699 27898060 | N/A | N/A | OmniPath |
| MAP2K4 | MAPK11 | 12788955 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | ATF2 | 10085140 11274345 12110590 12761180 14734562 15192015 15304344 17081983 17145710 17254968 17380123 18669648 19413330 19690332 20506250 27898060 9155018 9235954 9430721 | stimulant | N/A | OmniPath |
| MAP2K3 | MAPK11 | 11242034 18083107 19369195 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | TP53 | 17254968 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | TWIST1 | 21502402 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | HBP1 | 14612426 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | GYS1 | 14680475 17167773 17698598 19339242 19664994 19764811 20153492 21668450 22510711 27898060 | N/A | N/A | OmniPath |
| MAPK11 | SMAD2 | 20820849 27898060 | inhibition,stimulant | N/A | OmniPath |
| MAPK11 | NFE2L2 | 16951197 27898060 | inhibition | N/A | OmniPath |
| MAPK11 | DUSP1 | 11359773 27898060 | N/A | N/A | OmniPath |
| MAP2K6 | MAPK11 | 11242034 27898060 8621675 9430721 | stimulant | N/A | OmniPath |
| MAPK11 | RPTOR | 21757713 27898060 | N/A | N/A | OmniPath |
| TAB1 | MAPK11 | 11847341 16648477 25241761 27898060 | N/A | N/A | OmniPath |
| MAPK11 | TAB1 | 11847341 16648477 25241761 27898060 | inhibition | N/A | OmniPath |
| MAPK11 | MAPKAPK5 | 18669648 19690332 27898060 9628874 | stimulant | N/A | OmniPath |
| MAPK11 | DUSP10 | 11359773 27898060 | N/A | N/A | OmniPath |
| MAPK11 | ATF7 | 17081983 18669648 18950637 19413330 19690332 27898060 | N/A | N/A | OmniPath |
| SPAG9 | MAPK11 | 17074887 27898060 | stimulant | N/A | OmniPath |
| MAPK11 | DYRK1B | 12384504 27898060 | N/A | N/A | OmniPath |
| MAPK11 | HNF4A | 12740371 16351573 17317687 21708125 27898060 | N/A | N/A | OmniPath |
| MAPK11 | ZNHIT1 | 17380123 27898060 | N/A | N/A | OmniPath |