Gene Information gene info

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GENE：PSMA6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMA6
FullNmae proteasome 20S subunit alpha 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9535
EnsembleID ENSG00000100902
Uniprot P60900

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMA6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMA6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMA6 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
PSMA6 GO:0000502,GO:0000502,GO:0000932,GO:0003723,GO:0003723,GO:0004175,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0005839,GO:0005839,GO:0005844,GO:0010498,GO:0016363,GO:0019773,GO:0019773,GO:0019773,GO:0019773,GO:0030016,GO:0030017,GO:0035639,GO:0043161,GO:0050727,GO:0051059,GO:0051092,GO:0051603,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMA6 hsa:5687 path:hsa03050 Proteasome - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05020 Prion disease - Homo sapiens (human)
PSMA6 hsa:5687 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PSMA6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PSMA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001DE669 PSMA6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 PSMA6 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PSMA4 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMA4 25361965 interaction type N/A PTMCode2
PSMA6 USP14 25361965 interaction type N/A PTMCode2
USP14 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMD11 25361965 interaction type N/A PTMCode2
PSMD11 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMA5 25361965 interaction type N/A PTMCode2
PSMA5 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMC3 25361965 interaction type N/A PTMCode2
PSMC3 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMD1 25361965 interaction type N/A PTMCode2
PSMD1 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMA1 25361965 interaction type N/A PTMCode2
PSMA1 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 CUL1 25361965 interaction type N/A PTMCode2
CUL1 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMB10 25361965 interaction type N/A PTMCode2
PSMB10 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMA7 25361965 interaction type N/A PTMCode2
PSMA7 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA6 25361965 interaction type N/A PTMCode2
PSMC1 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMC1 25361965 interaction type N/A PTMCode2
PSMD7 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMD7 25361965 interaction type N/A PTMCode2
PSMA3 PSMA6 25361965 interaction type N/A PTMCode2
PSMA6 PSMA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOSC5 PSMA6 25348397 N/A physical interaction ComPPI
RTP5 PSMA6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMCO3 PSMA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZKSCAN4 PSMA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF1B PSMA6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
POLR2L PSMA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BAG3 PSMA6 25348397 N/A physical interaction ComPPI
SNRPA1 PSMA6 25348397 N/A physical interaction ComPPI
PSMC3 PSMA6 25348397 N/A physical interaction ComPPI
PSMC6 PSMA6 25348397 N/A physical interaction ComPPI
CCND1 PSMA6 25348397 N/A physical interaction ComPPI
KRTAP4-2 PSMA6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMD14 PSMA6 25348397 N/A physical interaction ComPPI
TRAF6 PSMA6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMD7 PSMA6 19581590 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP PSMA6 25348397 N/A physical interaction ComPPI
SKP1 PSMA6 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
KEAP1 PSMA6 25348397 N/A physical interaction ComPPI
MAP1LC3B PSMA6 25348397 N/A physical interaction ComPPI
PSMB2 PSMA6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DDIT4L PSMA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZBTB44 PSMA6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
JUN PSMA6 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
COPS5 PSMA6 25348397 N/A physical interaction ComPPI
LIG4 PSMA6 25348397 N/A physical interaction ComPPI
PSMA3 PSMA6 14525934 16169070 17948026 24234451 25348397 25416956 9451443 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
PSMD11 PSMA6 25348397 N/A physical interaction ComPPI
PAXIP1 PSMA6 25348397 N/A physical interaction ComPPI
RBX1 PSMA6 25348397 N/A physical interaction ComPPI
ACTN4 PSMA6 25348397 N/A physical interaction ComPPI
UBB PSMA6 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
UBC PSMA6 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
RPS27A PSMA6 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 PSMA6 25348397 N/A anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI
NTRK1 PSMA6 25348397 N/A physical interaction ComPPI
PLK1 PSMA6 11205743 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PSMA1 PSMA6 12376572 15225636 17948026 24234451 25348397 25599644 association,physical association affinity chromatography technology,anti bait coimmunoprecipitation,cosedimentation in solution,x-ray crystallography,physical interaction ComPPI,IntAct
PSMA6 PSMA4 14525934 15225636 17948026 19581590 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
PSMA6 PSMA7 14525934 14733938 15225636 17948026 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
PSMA6 PSMA2 14525934 14733938 15887188 17948026 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PSMA6 PSMD13 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 UBQLN2 10983987 25348397 26075709 27898060 N/A physical interaction ComPPI,OmniPath
PSMA6 USP14 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 SLX1A 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 CUL1 25348397 N/A physical interaction ComPPI
PSMA6 RNF185 25348397 N/A physical interaction ComPPI
PSMA6 XBP1 25348397 N/A pull down,physical interaction ComPPI
PSMA6 UBD 16707496 22072791 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMA6 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMD1 25348397 N/A physical interaction ComPPI
PSMA6 TXNL1 25348397 N/A physical interaction ComPPI
PSMA6 RAD23A 25348397 N/A physical interaction ComPPI
PSMA6 SEM1 25348397 N/A physical interaction ComPPI
PSMA6 PSME1 25348397 N/A physical interaction ComPPI
PSMA6 PPP3CA 21420386 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PSMA6 CCNE1 25348397 N/A physical interaction ComPPI
PSMA6 CCNA2 25348397 N/A physical interaction ComPPI
PSMA6 CCNB1 25348397 N/A physical interaction ComPPI
PSMA6 CDK4 25348397 N/A physical interaction ComPPI
PSMA6 CDK1 25348397 N/A physical interaction ComPPI
PSMA6 CDK2 25348397 N/A physical interaction ComPPI
PSMA6 CCNF 25348397 N/A physical interaction ComPPI
PSMA6 GPS1 25348397 N/A physical interaction ComPPI
PSMA6 PSMD6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMC1 25348397 N/A physical interaction ComPPI
PSMA6 FKBP8 25348397 N/A physical interaction ComPPI
PSMA6 NEDD8 25348397 N/A physical interaction ComPPI
PSMA6 DNAJB2 25348397 N/A physical interaction ComPPI
PSMA6 COPS2 25348397 N/A physical interaction ComPPI
PSMA6 UCHL5 16990800 18922472 19490896 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 POMP 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMB6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMB5 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMB8 25348397 N/A physical interaction ComPPI
PSMA6 USP4 25348397 N/A physical interaction ComPPI
PSMA6 PSMA5 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMB7 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 PSMC4 25348397 N/A physical interaction ComPPI
PSMA6 PSMC2 25348397 N/A physical interaction ComPPI
PSMA6 PSMD2 25348397 N/A physical interaction ComPPI
PSMA6 PSMD3 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMA6 PSMD8 25348397 N/A physical interaction ComPPI
PSMA6 PSMC5 25348397 N/A physical interaction ComPPI
PSMA6 PSMD12 25348397 N/A physical interaction ComPPI
PSMA6 PSMD5 25348397 N/A physical interaction ComPPI
PSMA6 PSME2 25348397 N/A physical interaction ComPPI
PSMA6 PSME3 25348397 N/A physical interaction ComPPI
PSMA6 PSMA8 25348397 N/A physical interaction ComPPI
PSMA6 SF3A1 25348397 N/A physical interaction ComPPI
PSMA6 CCT5 25348397 N/A physical interaction ComPPI
PSMA6 TPM4 25348397 N/A physical interaction ComPPI
PSMA6 CCT4 25348397 N/A physical interaction ComPPI
PSMA6 CCT3 25348397 N/A physical interaction ComPPI
PSMA6 EEF1A1 25348397 N/A physical interaction ComPPI
PSMA6 EEF1A1P5 25348397 N/A physical interaction ComPPI
PSMA6 CCT8 25348397 N/A physical interaction ComPPI
PSMA6 TARDBP 25348397 N/A physical interaction ComPPI
PSMA6 BRCA1 25348397 N/A physical interaction ComPPI
PSMA6 ECT2 25348397 N/A physical interaction ComPPI
PSMA6 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PSMA6 VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PSMA6 IQCB1 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 NOS2 25348397 N/A physical interaction ComPPI
PSMA6 ITGA4 25348397 N/A physical interaction ComPPI
PSMA6 PRKN 25348397 N/A physical interaction ComPPI
PSMA6 CAST 25348397 N/A physical interaction ComPPI
PSMA6 HNRNPA2B1 25348397 N/A physical interaction ComPPI
PSMA6 PYCR3 25348397 N/A physical interaction ComPPI
PSMA6 RPP30 25348397 N/A physical interaction ComPPI
PSMA6 RPP38 25348397 N/A physical interaction ComPPI
PSMA6 PSMG1 25348397 N/A physical interaction ComPPI
PSMA6 PSMG3 25348397 N/A physical interaction ComPPI
PSMA6 PSMG2 25348397 N/A physical interaction ComPPI
PSMA6 AURKA 25348397 N/A physical interaction ComPPI
PSMA6 HUWE1 25348397 N/A physical interaction ComPPI
PSMA6 CADM1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMA6 TRIM39 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMA6 BRME1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMA6 RNF170 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMA6 RNF2 25348397 N/A physical interaction ComPPI
PSMA6 AMFR 25348397 N/A physical interaction ComPPI
PSMA6 SYVN1 25348397 N/A physical interaction ComPPI
PSMA6 BUB1B 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 UBQLN1 25348397 N/A physical interaction ComPPI
PSMA6 PSMB9 25348397 N/A physical interaction ComPPI
PSMA6 HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
PSMA6 AMBRA1 25348397 N/A physical interaction ComPPI
PSMA6 CAND2 25348397 N/A physical interaction ComPPI
PSMA6 CAPZA1 25348397 N/A physical interaction ComPPI
PSMA6 ELP6 25348397 N/A physical interaction ComPPI
PSMA6 EXOSC4 25348397 N/A physical interaction ComPPI
PSMA6 EXOSC6 25348397 N/A physical interaction ComPPI
PSMA6 EXOSC9 25348397 N/A physical interaction ComPPI
PSMA6 ISY1 25348397 N/A physical interaction ComPPI
PSMA6 NELFE 25348397 N/A physical interaction ComPPI
PSMA6 PGK1 25348397 N/A physical interaction ComPPI
PSMA6 POLR2A 25348397 N/A physical interaction ComPPI
PSMA6 DNAJA2 25348397 N/A physical interaction ComPPI
PSMA6 TPM3 25348397 N/A physical interaction ComPPI
PSMA6 WDR11 25348397 N/A physical interaction ComPPI
PSMA6 FBXO7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMA6 MID1 25348397 N/A physical interaction ComPPI
PSMA6 CEP85 25348397 N/A physical interaction ComPPI
PSMA6 DERL1 25348397 N/A physical interaction ComPPI
PSMA6 CYLD 25348397 N/A physical interaction ComPPI
PSMA6 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMA6 SQSTM1 25348397 N/A physical interaction ComPPI
PSMA6 CFTR 25348397 N/A physical interaction ComPPI
PSMA6 ALKBH4 23145062 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMA6 HLA-C 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 TFE3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 FBXO11 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 FTSJ1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 SGK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 RIPK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 TIMP2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMA6 MDM2 22659184 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA6 DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
PSMA6 TEPSIN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMA6 DMBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMA6 ZNF596 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEM1 PSMA6 25348397 N/A physical interaction ComPPI
PSMB4 PSMA6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB1 PSMA6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB3 PSMA6 17948026 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ERH PSMA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ADRM1 PSMA6 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP53 PSMA6 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBXN4 PSMA6 25348397 N/A physical interaction ComPPI
ECPAS PSMA6 25348397 N/A physical interaction ComPPI
LIMD2 PSMA6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct

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