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GENE：PRKACB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKACB
FullNmae protein kinase cAMP-activated catalytic subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9381
EnsembleID ENSG00000142875
Uniprot P22694

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKACB pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKACB apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKACB GO:0000287,GO:0001843,GO:0003091,GO:0004674,GO:0004679,GO:0004691,GO:0004691,GO:0004691,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0005829,GO:0005886,GO:0005952,GO:0005952,GO:0006468,GO:0007165,GO:0007188,GO:0010737,GO:0018105,GO:0031625,GO:0034380,GO:0070062,GO:0070613,GO:0097546,GO:0106310,GO:1901621,GO:1904262

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKACB hsa:5567 path:hsa01522 Endocrine resistance - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04340 Hedgehog signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04530 Tight junction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04540 Gap junction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04611 Platelet activation - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04713 Circadian entrainment - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04714 Thermogenesis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04720 Long-term potentiation - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04727 GABAergic synapse - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04740 Olfactory transduction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04742 Taste transduction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04911 Insulin secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04916 Melanogenesis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04924 Renin secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04934 Cushing syndrome - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04970 Salivary secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa04976 Bile secretion - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05012 Parkinson disease - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05020 Prion disease - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05030 Cocaine addiction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05032 Morphine addiction - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05034 Alcoholism - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05110 Vibrio cholerae infection - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05146 Amoebiasis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PRKACB hsa:5567 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOXA1 PRKACB 20110267 23180781 phosphorylation reaction in-gel kinase assay InnateDB
PRKACB PREX1 16301320 23109003 inhibition N/A SignaLink
CAMP PRKACB 15539636 16460834 23109003 7935349 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR PRKACB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PRKACB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PRKACB 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRKACB 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 PRKACB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PRKACB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000183BED PRKACB 22449550 24916040 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunocytochemistry,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 PRKACB 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00002075FA PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004DA9DB PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000D6C3F PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 PRKACB 21572407 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACB NGFR 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PDE4DIP PRKACB 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPRE1 PRKACB 23455922 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
GPKOW PRKACB 25348397 N/A two hybrid ComPPI
DYNLL1 PRKACB 23455922 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CEP43 PRKACB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR2B PRKACB 23455922 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PKIG PRKACB 25348397 N/A physical interaction ComPPI
TRAF6 PRKACB 25348397 N/A physical interaction ComPPI
RABGGTB PRKACB 25348397 N/A physical interaction ComPPI
AVPI1 PRKACB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TNP2 PRKACB 25348397 N/A physical interaction ComPPI
HSP90AB1 PRKACB 22939624 23455922 24234451 25348397 association,physical association physical interaction,tandem affinity purification,luminescence based mammalian interactome mapping ComPPI,IntAct
APPBP2 PRKACB 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PRKACB PKIA 12798691 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
PRKACB PKIB 14525934 25348397 7684369 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKACB NGFR 12682012 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PRKACB RYR2 25348397 N/A physical interaction ComPPI
PRKACB TNP1 25348397 N/A physical interaction ComPPI
PRKACB SPP1 25348397 N/A physical interaction ComPPI
PRKACB PRKAR2A 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB PRKACA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB HSP90AA1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKACB CSNK2A1 25348397 N/A physical interaction,protein kinase assay ComPPI
PRKACB ARFGAP1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKACB RPS6 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKACB RPL27A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKACB ACVR1B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKACB KIFBP 25348397 N/A physical interaction ComPPI
PRKACB ACTR2 25348397 N/A physical interaction ComPPI
PRKACB ACTR3 25348397 N/A physical interaction ComPPI
PRKACB ARPC1B 25348397 N/A physical interaction ComPPI
PRKACB ARPC2 25348397 N/A physical interaction ComPPI
PRKACB ARPC4 25348397 N/A physical interaction ComPPI
PRKACB PFDN1 25348397 N/A physical interaction ComPPI
PRKACB SUMO1 25348397 N/A physical interaction ComPPI
PRKACB TPRKB 25348397 N/A physical interaction ComPPI
PRKACB VAPB 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB PRKAR1A 23455922 24234451 25348397 association two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB AKAP5 23455922 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB PRKAR1B 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB DCAF7 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB TRAP1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB DYRK1A 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB AKAP1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB CDK5RAP2 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB AKAP9 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB VAPA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB AKAP7 25348397 N/A physical interaction ComPPI
PRKACB AKAP7 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB AKAP11 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKACB MLF1 25348397 N/A physical interaction ComPPI
PRKACB NAPG 25348397 N/A physical interaction ComPPI
PRKACB PER1 25348397 N/A physical interaction ComPPI
PRKACB TALDO1 25348397 N/A physical interaction ComPPI
PRKACB C11ORF49 25348397 N/A physical interaction ComPPI
PRKACB AP2M1 25348397 N/A physical interaction ComPPI
PRKACB DCLRE1C 25348397 N/A physical interaction ComPPI
PRKACB CCNL2 25348397 N/A physical interaction ComPPI
PRKACB AKAP14 25348397 N/A physical interaction ComPPI
PRKACB ARF1 25348397 N/A physical interaction ComPPI
PRKACB RPE 25348397 N/A physical interaction ComPPI
PRKACB NTRK1 25348397 N/A physical interaction ComPPI
PRKACB XPO1 25348397 N/A physical interaction ComPPI
PRKACB GPR161 25348397 N/A physical interaction ComPPI
PRKACB PRKACG 25348397 N/A physical interaction ComPPI
PRKACB FKBP5 25348397 N/A physical interaction ComPPI
PRKACB BMP1 25348397 N/A physical interaction ComPPI
PRKACB MRPS15 25348397 N/A physical interaction ComPPI
PRKACB ETFB 25348397 N/A physical interaction ComPPI
PRKACB NPAS1 25348397 N/A physical interaction ComPPI
PRKACB DFFB 25348397 N/A physical interaction ComPPI
PRKACB RAPGEF5 25348397 N/A physical interaction ComPPI
PRKACB KLHL28 25348397 N/A physical interaction ComPPI
PRKACB DNA2 25348397 N/A physical interaction ComPPI
PRKACB TRIM25 25348397 N/A physical interaction ComPPI
PRKACB HNRNPL 25348397 N/A physical interaction ComPPI
PRKACB MAVS 25348397 N/A physical interaction ComPPI
PRKACB TRAF3 25348397 N/A physical interaction ComPPI
PRKACB FLNA 15225631 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PRKACB RCAN1 19755121 24234451 25348397 27898060 phosphorylation reaction protein kinase assay ComPPI,IntAct,OmniPath
PRKACB PITX2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKACB CBFB 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PRKACB CEP170P1 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKACB GSK3B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TP53RK PRKACB 25348397 N/A physical interaction ComPPI
H2BC9 PRKACB 24234451 30021884 physical association cross-linking study IntAct
PRKACB BAD 10949026 27898060 inhibition,stimulant N/A OmniPath
PRKACB NOXA1 20110267 27898060 N/A N/A OmniPath
PRKACB NGFR 12682012 26119933 27898060 stimulant N/A OmniPath
PRKACB MYBPC3 20151718 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B2C47 PRKACB 27087310 direct interaction,inhibition N/A NPInter

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