Gene Information gene info

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GENE：LEFTY2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LEFTY2
FullNmae left-right determination factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3122
EnsembleID ENSG00000143768
Uniprot O00292

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LEFTY2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LEFTY2 GO:0005125,GO:0005160,GO:0005576,GO:0005615,GO:0007165,GO:0008083,GO:0009948,GO:0031093,GO:0062023

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LEFTY2 hsa:7044 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
LEFTY2 hsa:7044 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 LEFTY2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ZNF263 LEFTY2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070CD2 LEFTY2 21266536 rna interference,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS000041E949 LEFTY2 21266536 rna interference,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000070CD2 LEFTY2 21266536 25416803 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000041E949 LEFTY2 21266536 25416803 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000508C13 LEFTY2 24709321 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000011DF LEFTY2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA LEFTY2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK8IP2 LEFTY2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LEFTY2 POU5F1 20505756 24234451 physical association cross-linking study IntAct
LEFTY2 TDGF1 22710174 27898060 N/A N/A OmniPath

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