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GENE：PSMC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMC2
FullNmae proteasome 26S subunit, ATPase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9548
EnsembleID ENSG00000161057
Uniprot P35998

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMC2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMC2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMC2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSMC2 GO:0000502,GO:0000502,GO:0000932,GO:0001649,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0006511,GO:0008540,GO:0016020,GO:0016887,GO:0022624,GO:0034774,GO:0036402,GO:0036402,GO:0036402,GO:0036464,GO:0043161,GO:0043161,GO:1901800,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMC2 hsa:5701 path:hsa03050 Proteasome - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05020 Prion disease - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PSMC2 hsa:5701 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PSMC2 TRAF6 14743216 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PSMC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PSMC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PSMC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PSMC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PSMC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE PSMC2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000D5659 PSMC2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 PSMC2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNW1 PSMC2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC73 PSMC2 25348397 N/A physical interaction ComPPI
CDC5L PSMC2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NDC80 PSMC2 14525934 25348397 9295362 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RPN1 PSMC2 25348397 N/A physical interaction ComPPI
BAG3 PSMC2 25348397 N/A physical interaction ComPPI
LDHB PSMC2 25348397 N/A physical interaction ComPPI
LDHA PSMC2 25348397 N/A physical interaction ComPPI
CDKN1A PSMC2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
SKIL PSMC2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PSMC3 PSMC2 22901813 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMC2 19490896 22901813 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
TUBB PSMC2 25348397 N/A physical interaction ComPPI
PSMD14 PSMC2 19615732 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 PSMC2 14525934 14743216 24234451 25348397 physical association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
PSMD7 PSMC2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD21 PSMC2 25348397 N/A physical interaction ComPPI
GTF2B PSMC2 11118327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PSMB2 PSMC2 25348397 N/A physical interaction ComPPI
VBP1 PSMC2 25348397 N/A physical interaction ComPPI
INSIG2 PSMC2 25348397 N/A physical interaction ComPPI
ABRAXAS2 PSMC2 19214193 24234451 25348397 association biochemical ComPPI,IntAct
TBP PSMC2 11118327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRB2 PSMC2 25348397 N/A physical interaction ComPPI
JUN PSMC2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMA3 PSMC2 25348397 N/A physical interaction ComPPI
PSMD11 PSMC2 25348397 N/A physical interaction ComPPI
CUL3 PSMC2 25348397 N/A physical interaction ComPPI
GTF2H1 PSMC2 11118327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBB PSMC2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC PSMC2 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
RPS27A PSMC2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 PSMC2 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
NTRK1 PSMC2 25348397 N/A physical interaction ComPPI
CANX PSMC2 25348397 N/A physical interaction ComPPI
YBX1 PSMC2 25348397 N/A physical interaction ComPPI
PTPN2 PSMC2 25348397 N/A physical interaction ComPPI
PSMA1 PSMC2 25348397 N/A physical interaction ComPPI
PSMA6 PSMC2 25348397 N/A physical interaction ComPPI
PSMA5 PSMC2 25348397 N/A physical interaction ComPPI
PSMB9 PSMC2 25348397 N/A physical interaction ComPPI
MAP3K5 PSMC2 25348397 N/A physical interaction ComPPI
MYC PSMC2 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPT PSMC2 25348397 N/A physical interaction ComPPI
UBR5 PSMC2 25348397 N/A physical interaction ComPPI
CAD PSMC2 25348397 N/A physical interaction ComPPI
DUSP16 PSMC2 24234451 25348397 28330616 association pull down ComPPI,IntAct
CFTR PSMC2 25348397 N/A physical interaction ComPPI
MAPK6 PSMC2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMD8 PSMC2 25348397 N/A physical interaction ComPPI
SQSTM1 PSMC2 25348397 N/A physical interaction ComPPI
NDRG1 PSMC2 14525934 17220478 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
RELA PSMC2 25348397 N/A physical interaction ComPPI
PSMB8 PSMC2 25348397 N/A physical interaction ComPPI
PSMD1 PSMC2 25348397 N/A physical interaction ComPPI
UBR2 PSMC2 25348397 N/A physical interaction ComPPI
GRK5 PSMC2 25348397 N/A physical interaction ComPPI
XPO1 PSMC2 25348397 N/A physical interaction ComPPI
AHR PSMC2 25348397 N/A physical interaction ComPPI
PSMC5 PSMC2 16763564 19490896 22901813 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ABCE1 PSMC2 25348397 N/A physical interaction ComPPI
HUWE1 PSMC2 25348397 N/A physical interaction ComPPI
UBQLN2 PSMC2 25348397 N/A physical interaction ComPPI
RAD23A PSMC2 16712842 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
SMC1A PSMC2 25348397 N/A physical interaction ComPPI
PSMC4 PSMC2 11361004 14525934 17353931 22901813 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HSPA4 PSMC2 25348397 N/A physical interaction ComPPI
RNF2 PSMC2 25348397 N/A physical interaction ComPPI
CIITA PSMC2 25348397 N/A physical interaction ComPPI
GTF2F1 PSMC2 11118325 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
YAP1 PSMC2 25348397 N/A physical interaction ComPPI
SMC3 PSMC2 25348397 N/A physical interaction ComPPI
NOS2 PSMC2 25348397 N/A physical interaction ComPPI
PSMD2 PSMC2 10625621 14525934 22901813 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
DNM1L PSMC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HIF1AN PSMC2 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
RAD23B PSMC2 16712842 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
MID1 PSMC2 25348397 N/A physical interaction ComPPI
MID2 PSMC2 25348397 N/A physical interaction ComPPI
PRKN PSMC2 25348397 N/A physical interaction ComPPI
PSMD10 PSMC2 17353931 19490896 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD4 PSMC2 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SUCLA2 PSMC2 25348397 N/A physical interaction ComPPI
FKBP8 PSMC2 25348397 N/A physical interaction ComPPI
NFKB1 PSMC2 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
SEM1 PSMC2 24234451 24811749 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMB5 PSMC2 22901813 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSME3 PSMC2 25348397 N/A physical interaction ComPPI
PSME1 PSMC2 25348397 N/A physical interaction ComPPI
PSME2 PSMC2 25348397 N/A physical interaction ComPPI
CRY2 PSMC2 25348397 N/A physical interaction ComPPI
UBQLN1 PSMC2 25348397 N/A physical interaction ComPPI
PSMC1 PSMC2 10625621 14525934 19490896 22901813 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
AMFR PSMC2 25348397 N/A physical interaction ComPPI
DERL1 PSMC2 25348397 N/A physical interaction ComPPI
ESR1 PSMC2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
ESR2 PSMC2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
RPS6KB2 PSMC2 25348397 N/A physical interaction ComPPI
SNRNP200 PSMC2 25348397 N/A physical interaction ComPPI
KPNA6 PSMC2 25348397 N/A physical interaction ComPPI
BRCA1 PSMC2 25348397 N/A physical interaction ComPPI
MCFD2 PSMC2 25348397 N/A physical interaction ComPPI
PSMB4 PSMC2 25348397 N/A physical interaction ComPPI
BAP1 PSMC2 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMB1 PSMC2 25348397 N/A physical interaction ComPPI
PSMB3 PSMC2 25348397 N/A physical interaction ComPPI
PSMB7 PSMC2 25348397 N/A physical interaction ComPPI
PSMA7 PSMC2 25348397 N/A physical interaction ComPPI
PSMA4 PSMC2 25348397 N/A physical interaction ComPPI
SOD1 PSMC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
ATXN7 PSMC2 25348397 N/A physical interaction ComPPI
POMP PSMC2 25348397 N/A physical interaction ComPPI
DNAJA1 PSMC2 25348397 N/A physical interaction ComPPI
PSMD5 PSMC2 10625621 14525934 16189514 19490896 21516116 24234451 25348397 25416956 27107012 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
TPM4 PSMC2 25348397 N/A physical interaction ComPPI
DCTN2 PSMC2 25348397 N/A physical interaction ComPPI
PPM1D PSMC2 24234451 25348397 28330616 association pull down ComPPI,IntAct
IKBKE PSMC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RAB5C PSMC2 25348397 N/A physical interaction ComPPI
UBE2C PSMC2 25348397 N/A physical interaction ComPPI
SEC23A PSMC2 25348397 N/A physical interaction ComPPI
MPG PSMC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SHMT2 PSMC2 25348397 N/A physical interaction ComPPI
TRIM5 PSMC2 22078707 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UCHL5 PSMC2 18922472 19490896 19615732 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
L3MBTL1 PSMC2 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PMS2 PSMC2 25348397 N/A physical interaction ComPPI
ADRM1 PSMC2 24234451 24811749 25348397 association physical interaction,blue native page ComPPI,IntAct
PSMD13 PSMC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMD12 PSMC2 25348397 N/A physical interaction ComPPI
CYLD PSMC2 25348397 N/A physical interaction ComPPI
CCND2 PSMC2 25348397 N/A physical interaction ComPPI
FTSJ3 PSMC2 25348397 N/A physical interaction ComPPI
PSMD9 PSMC2 25348397 N/A physical interaction ComPPI
UBLCP1 PSMC2 25348397 N/A physical interaction ComPPI
PSMC2 SUMO4 14525934 16236267 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PSMC2 PSMD6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC2 PAAF1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC2 MYZAP 25348397 N/A physical interaction,two hybrid fragment pooling approach ComPPI
PSMC2 POLR2M 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
PSMC2 USP14 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC2 PMS2CL 25348397 N/A physical interaction ComPPI
PSMC2 ATG4C 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC2 RNF185 25348397 N/A physical interaction ComPPI
PSMC2 SEM1 25348397 N/A physical interaction ComPPI
PSMC2 PCK1 25348397 N/A physical interaction ComPPI
PSMC2 SIRT7 25348397 N/A physical interaction ComPPI
PSMC2 PSMA2 25348397 N/A physical interaction ComPPI
PSMC2 PSMD3 25348397 N/A physical interaction ComPPI
PSMC2 PSMB6 25348397 N/A physical interaction ComPPI
PSMC2 PSMA8 25348397 N/A physical interaction ComPPI
PSMC2 CCT8 25348397 N/A physical interaction ComPPI
PSMC2 ZCCHC8 25348397 N/A physical interaction ComPPI
PSMC2 UFC1 25348397 N/A physical interaction ComPPI
PSMC2 MRPS16 25348397 N/A physical interaction ComPPI
PSMC2 VPS26A 25348397 N/A physical interaction ComPPI
PSMC2 PCDH10 25348397 N/A physical interaction ComPPI
PSMC2 FBXO6 25348397 N/A physical interaction ComPPI
PSMC2 CLIP1 25348397 N/A physical interaction ComPPI
PSMC2 RPS21 25348397 N/A physical interaction ComPPI
PSMC2 TXNL1 25348397 N/A physical interaction ComPPI
PSMC2 SPRTN 25348397 N/A physical interaction ComPPI
PSMC2 NXF1 25348397 N/A physical interaction ComPPI
PSMC2 CCDC74B 25348397 N/A physical interaction ComPPI
PSMC2 NEURL4 25348397 N/A physical interaction ComPPI
PSMC2 MTMR1 25348397 N/A physical interaction ComPPI
PSMC2 COX7A2 25348397 N/A physical interaction ComPPI
PSMC2 AMBRA1 25348397 N/A physical interaction ComPPI
PSMC2 CCT2 25348397 N/A physical interaction ComPPI
PSMC2 CCT3 25348397 N/A physical interaction ComPPI
PSMC2 DNAJA4 25348397 N/A physical interaction ComPPI
PSMC2 GFPT1 25348397 N/A physical interaction ComPPI
PSMC2 NFS1 25348397 N/A physical interaction ComPPI
PSMC2 CCT4 25348397 N/A physical interaction ComPPI
PSMC2 CCT6A 25348397 N/A physical interaction ComPPI
PSMC2 CCT6B 25348397 N/A physical interaction ComPPI
PSMC2 IPO4 25348397 N/A physical interaction ComPPI
PSMC2 MTCH1 25348397 N/A physical interaction ComPPI
PSMC2 HERC3 25348397 N/A physical interaction ComPPI
PSMC2 CEP85 25348397 N/A physical interaction ComPPI
PSMC2 ATOH1 25348397 N/A physical interaction ComPPI
PSMC2 CCDC92 25348397 N/A physical interaction ComPPI
PSMC2 USP44 25348397 N/A physical interaction ComPPI
PSMC2 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC2 ASXL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC2 UNC45B 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PSMC2 NBEAL2 24234451 25348397 29187380 association tandem affinity purification ComPPI,IntAct
ACADM PSMC2 25348397 N/A physical interaction ComPPI
GH1 PSMC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ECPAS PSMC2 25348397 N/A physical interaction ComPPI
PSMC2 POLR2M 14525934 16169070 N/A two hybrid HPRD
TRAF6 PSMC2 14743216 27898060 N/A N/A OmniPath

Visualization










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