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GENE：SHC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SHC2
FullNmae SHC adaptor protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29869
EnsembleID ENSG00000129946
Uniprot P98077

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SHC2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SHC2 GO:0005515,GO:0005575,GO:0005829,GO:0005886,GO:0007169,GO:0030971,GO:0035556

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SHC2 hsa:25759 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
SHC2 hsa:25759 path:hsa01522 Endocrine resistance - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04510 Focal adhesion - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
SHC2 hsa:25759 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05034 Alcoholism - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05214 Glioma - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05224 Breast cancer - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
SHC2 hsa:25759 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGFR SHC2 23331499 8760305 stimulation N/A SignaLink
SHC2 KDR 10749680 1220983 23331499 stimulation N/A SignaLink
KDR SHC2 10749680 23331499 9790910 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SHC2 ERBB2 20005715 interaction type N/A PSP,SignaLink
SHC2 NTRK1 20005715 interaction type N/A PSP
SHC2 KDR 20005715 interaction type N/A PSP,SignaLink
SHC2 NTRK3 20005715 interaction type N/A PSP
SHC2 NTRK2 20005715 interaction type N/A PSP
SHC2 NTRK3 12006576 18988627 20005715 N/A N/A SignaLink
SHC2 NTRK1 12006576 18988627 20005715 20005715 9507002 N/A N/A SignaLink
SHC2 NTRK2 12006576 18988627 20005715 20005715 9507002 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 SHC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SHC2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 SHC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SHC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 SHC2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
KDR SHC2 25361965 interaction type N/A PTMCode2
SHC2 KDR 25361965 interaction type N/A PTMCode2
SHC2 EGFR 25361965 interaction type N/A PTMCode2
EGFR SHC2 25361965 interaction type N/A PTMCode2
SHC2 NTRK2 25361965 interaction type N/A PTMCode2
NTRK2 SHC2 25361965 interaction type N/A PTMCode2
SHC2 FLT1 25361965 interaction type N/A PTMCode2
FLT1 SHC2 25361965 interaction type N/A PTMCode2
SHC2 INSR 25361965 interaction type N/A PTMCode2
INSR SHC2 25361965 interaction type N/A PTMCode2
SHC2 GRB2 25361965 interaction type N/A PTMCode2
GRB2 SHC2 25361965 interaction type N/A PTMCode2
SHC2 ERBB4 25361965 interaction type N/A PTMCode2
ERBB4 SHC2 25361965 interaction type N/A PTMCode2
SHC2 RET 25361965 interaction type N/A PTMCode2
RET SHC2 25361965 interaction type N/A PTMCode2
SHC2 SRC 25361965 interaction type N/A PTMCode2
SRC SHC2 25361965 interaction type N/A PTMCode2
SHC2 NTRK3 25361965 interaction type N/A PTMCode2
NTRK3 SHC2 25361965 interaction type N/A PTMCode2
SHC2 SOS1 25361965 interaction type N/A PTMCode2
SOS1 SHC2 25361965 interaction type N/A PTMCode2
CSF1R SHC2 25361965 interaction type N/A PTMCode2
SHC2 CSF1R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ERBB2 SHC2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
ERRFI1 SHC2 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
KIT SHC2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
FLT1 SHC2 25348397 N/A physical interaction ComPPI
KDR SHC2 10749680 14525934 25348397 9790910 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
SHC1 SHC2 25348397 N/A physical interaction ComPPI
GRB2 SHC2 12006576 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NTRK1 SHC2 12006576 14525934 25348397 9507002 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
NTRK2 SHC2 12006576 14525934 25348397 9507002 N/A experimental interaction detection,in vivo ComPPI,HPRD
HNRNPL SHC2 25348397 N/A physical interaction ComPPI
MET SHC2 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
EGFR SHC2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
SHC2 ARHGAP32 25348397 N/A physical interaction ComPPI
SHC2 NTRK3 12006576 14525934 N/A experimental interaction detection,two hybrid HPRD
EGFR SHC2 11350724 16273093 27898060 8760305 stimulant N/A OmniPath
KDR SHC2 1074968 10749680 1220983 27898060 9790910 stimulant N/A OmniPath
SHC2 KDR 1074968 10749680 1220983 27898060 9790910 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BEEB4 SHC2 27087310 direct interaction,inhibition N/A NPInter

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