Gene Information gene info

  1. Home

GENE：RPS6KA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RPS6KA2
FullNmae ribosomal protein S6 kinase A2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10431
EnsembleID ENSG00000071242
Uniprot Q15349

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RPS6KA2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RPS6KA2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RPS6KA2 GO:0000287,GO:0001556,GO:0002035,GO:0004674,GO:0004711,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0007165,GO:0007268,GO:0007507,GO:0008285,GO:0010628,GO:0010659,GO:0016310,GO:0018105,GO:0035556,GO:0043065,GO:0045202,GO:0045786,GO:0045835,GO:0060047,GO:0070613,GO:0071322,GO:0072687,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RPS6KA2 hsa:6196 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04714 Thermogenesis - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04720 Long-term potentiation - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa04931 Insulin resistance - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa05135 Yersinia infection - Homo sapiens (human)
RPS6KA2 hsa:6196 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK1 RPS6KA2 12832467 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK3 RPS6KA2 12832467 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
MAGI1 RPS6KA2 20005715 interaction type N/A PSP
RPS6 RPS6KA2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR RPS6KA2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 RPS6KA2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 RPS6KA2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 RPS6KA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 RPS6KA2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RPS6KA2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 RPS6KA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC RPS6KA2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 RPS6KA2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000014F13C RPS6KA2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA RPS6KA2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 RPS6KA2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A RPS6KA2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F RPS6KA2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 RPS6KA2 22291592 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
RPS6KA2 RPS6KA2 22135298 phosphorylation N/A PhosphoSite
RPS6KA2 CREB1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLD1 RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 PLD1 25361965 interaction type N/A PTMCode2
MAPK1 RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 MAPK1 25361965 interaction type N/A PTMCode2
BAD RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 BAD 25361965 interaction type N/A PTMCode2
HTR2A RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 HTR2A 25361965 interaction type N/A PTMCode2
RPS6KA2 RPS6 25361965 interaction type N/A PTMCode2
RPS6 RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 HMGN1 25361965 interaction type N/A PTMCode2
HMGN1 RPS6KA2 25361965 interaction type N/A PTMCode2
CREB1 RPS6KA2 25361965 interaction type N/A PTMCode2
PEA15 RPS6KA2 25361965 interaction type N/A PTMCode2
RPS6KA2 PEA15 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NQO2 RPS6KA2 25348397 N/A physical interaction ComPPI
HSP90AB1 RPS6KA2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
BAD RPS6KA2 25348397 N/A in vitro,in vivo ComPPI
MAPK1 RPS6KA2 23602568 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach ComPPI,IntAct
SYK RPS6KA2 25348397 N/A physical interaction,biochemical ComPPI
PRKCA RPS6KA2 16810323 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SPRED2 RPS6KA2 25348397 N/A physical interaction ComPPI
MAPK3 RPS6KA2 23602568 24234451 25241761 25348397 association,physical association physical interaction,in vitro,in vivo,tandem affinity purification,proximity ligation assay ComPPI,IntAct
JUN RPS6KA2 25348397 N/A physical interaction ComPPI
CREBBP RPS6KA2 25348397 N/A physical interaction ComPPI
FGFR2 RPS6KA2 25348397 N/A physical interaction ComPPI
PRKCE RPS6KA2 16810323 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FLNC RPS6KA2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AA1 RPS6KA2 25348397 N/A physical interaction ComPPI
ZMYM5 RPS6KA2 25348397 N/A physical interaction ComPPI
MAGI1 RPS6KA2 25348397 N/A two hybrid ComPPI
L1CAM RPS6KA2 25348397 N/A in vitro,in vivo ComPPI
MAP2K1 RPS6KA2 25348397 N/A in vitro ComPPI
RPS6KA2 SHANK1 24234451 25348397 30126976 N/A two hybrid,p8 filamentous phage display,microscale thermophoresis ComPPI,IntAct
RPS6KA2 CREB1 25348397 N/A in vitro,in vivo ComPPI
RPS6KA2 FOS 25348397 N/A physical interaction ComPPI
RPS6KA2 STXBP2 25348397 N/A physical interaction ComPPI
RPS6KA2 HSP90AA2P 25348397 N/A physical interaction ComPPI
RPS6KA2 CSNK2B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA2 RPS6KA1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RPS6KA2 FAT1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS6KA2 GRSF1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS6KA2 SHROOM3 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS6KA2 ECE2 25348397 N/A physical interaction ComPPI
RPS6KA2 MISP 25348397 N/A physical interaction ComPPI
RPS6KA2 FYN 25348397 N/A physical interaction ComPPI
RPS6KA2 IL17RA 25348397 N/A physical interaction ComPPI
RPS6KA2 TRIM11 25348397 N/A physical interaction ComPPI
RPS6KA2 STRADB 25348397 N/A physical interaction ComPPI
RPS6KA2 IRGC 25348397 N/A physical interaction ComPPI
RPS6KA2 ALOX5 25348397 N/A physical interaction ComPPI
RPS6KA2 TRIM25 25348397 N/A physical interaction ComPPI
RPS6KA2 HNRNPL 25348397 N/A physical interaction ComPPI
RPS6KA2 BRAF 16810323 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPS6KA2 RPS6 16810323 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
RPS6KA2 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PKM RPS6KA2 25348397 N/A protein kinase assay ComPPI
RPS6KA2 DLG1 24234451 30126976 N/A microscale thermophoresis IntAct
RPS6KA2 SCRIB 24234451 29144123 30126976 physical association anti tag coimmunoprecipitation,isothermal titration calorimetry,nuclear magnetic resonance,pull down,p8 filamentous phage display,microscale thermophoresis IntAct
RPS6KA2 CREB1 11175347 11698596 27898060 8688081 9687510 9829964 stimulant N/A OmniPath
RPS6KA2 CDKN1B 12244301 12244302 12244303 14504289 27898060 N/A N/A OmniPath
RPS6KA2 BAD 10521512 10558990 10837486 10880354 10949026 12897128 18669648 18707149 19282669 20166139 27898060 9381178 inhibition,stimulant N/A OmniPath
PDPK1 RPS6KA2 10480933 17192257 17906627 19369195 27898060 stimulant N/A OmniPath
RPS6KA2 PDPK1 17906627 27898060 N/A N/A OmniPath
RPS6KA2 FOS 11585927 27898060 9920881 N/A N/A OmniPath
MAPK3 RPS6KA2 12832467 17906627 23602568 25241761 27898060 8939914 stimulant N/A OmniPath
RPS6KA2 NFKBIA 20385620 27898060 inhibition N/A OmniPath
MAPK1 RPS6KA2 12832467 17906627 19282669 23602568 25852190 27898060 8939914 9915826 stimulant N/A OmniPath
RPS6KA2 MAPK1 12832467 23602568 25852190 27898060 8939914 9915826 N/A N/A OmniPath
RPS6KA2 DAPK1 11579085 16213824 27898060 N/A N/A OmniPath
MTOR RPS6KA2 15060135 27898060 stimulant N/A OmniPath
RPS6KA2 ATF4 11238952 15109498 27898060 stimulant N/A OmniPath
RPS6KA2 NFATC4 15657420 27898060 stimulant N/A OmniPath
RPS6KA2 RRN3 12620228 27898060 N/A N/A OmniPath
RPS6KA2 MEF2C 17630987 27898060 8663403 9069290 N/A N/A OmniPath

Visualization










  Return