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GENE：NFATC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NFATC4
FullNmae nuclear factor of activated T cells 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7778
EnsembleID ENSG00000100968
Uniprot Q14934

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NFATC4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFATC4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFATC4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NFATC4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NFATC4 GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001569,GO:0001816,GO:0005515,GO:0005634,GO:0005667,GO:0005829,GO:0006357,GO:0006366,GO:0006954,GO:0007507,GO:0007616,GO:0008134,GO:0008630,GO:0016607,GO:0030178,GO:0031547,GO:0032760,GO:0033173,GO:0034644,GO:0042975,GO:0043524,GO:0043525,GO:0045333,GO:0045944,GO:0048813,GO:0050774,GO:0051402,GO:0060074,GO:0060291,GO:0071285,GO:0097084,GO:1902894,GO:1990837,GO:2000297,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NFATC4 hsa:4776 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04148 Efferocytosis - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04218 Cellular senescence - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04360 Axon guidance - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa05161 Hepatitis B - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
NFATC4 hsa:4776 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFATC4 MAPK8 17875713 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
NFATC4 MAPK9 17875713 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
NFATC4 CEBPA 20392859 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC4 TNF 16027109 23180781 physical association DNase I footprinting InnateDB
NFATC4 BACE1 23180781 25663301 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 NFATC4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 NFATC4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NFATC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NFATC4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000210075 NFATC4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000079D48 NFATC4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 NFATC4 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 NFATC4 22135298 phosphorylation N/A PhosphoSite
CDK3 NFATC4 22135298 phosphorylation N/A PhosphoSite
MAPK14 NFATC4 22135298 phosphorylation N/A PhosphoSite
MAPK1 NFATC4 22135298 phosphorylation N/A PhosphoSite
MAPK9 NFATC4 22135298 phosphorylation N/A PhosphoSite
MAPK8 NFATC4 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 NFATC4 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MAPK9 NFATC4 25348397 N/A physical interaction ComPPI
MAPK8 NFATC4 25348397 N/A physical interaction ComPPI
JUN NFATC4 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CREBBP NFATC4 11514544 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
MAPK14 NFATC4 11997522 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
JUP NFATC4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
YWHAZ NFATC4 10611249 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBC NFATC4 19026640 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
NR1I2 NFATC4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
YWHAQ NFATC4 10611249 14525934 24234451 25348397 association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
GATA4 NFATC4 14525934 25348397 9568714 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CCNG1 NFATC4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NLGN3 NFATC4 25348397 N/A physical interaction ComPPI
NFATC4 LPIN1 25348397 N/A physical interaction ComPPI
NFATC4 CEBPA 25348397 N/A physical interaction ComPPI
NFATC4 GPR22 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NFATC4 ANKRD28 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
NFATC4 PPP3CA 25348397 N/A physical interaction ComPPI
NFATC4 PPP3CC 25348397 N/A physical interaction ComPPI
NFATC4 PASK 21418524 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PPP3CA NFATC4 10860980 16407284 21880741 27898060 stimulant N/A OmniPath
ROCK1 NFATC4 15657420 27898060 N/A N/A OmniPath
MAPK9 NFATC4 17875713 27898060 inhibition N/A OmniPath
NFATC4 MAPK9 17875713 27898060 N/A N/A OmniPath
MAPK7 NFATC4 11997522 18347059 27898060 N/A N/A OmniPath
MAPK3 NFATC4 15657420 27898060 stimulant N/A OmniPath
MAPK14 NFATC4 11997522 18347059 25241761 27898060 stimulant N/A OmniPath
RPS6KA3 NFATC4 15657420 17081983 17213202 18220336 27898060 stimulant N/A OmniPath
MAPK1 NFATC4 15657420 27898060 stimulant N/A OmniPath
RPS6KA2 NFATC4 15657420 27898060 stimulant N/A OmniPath
MAPK8 NFATC4 17875713 27898060 inhibition N/A OmniPath
NFATC4 MAPK8 17875713 27898060 stimulant N/A OmniPath

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