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GENE：GDF6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GDF6
FullNmae growth differentiation factor 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4221
EnsembleID ENSG00000156466
Uniprot Q6KF10

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GDF6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GDF6 GO:0001656,GO:0005125,GO:0005615,GO:0006915,GO:0008083,GO:0030509,GO:0030509,GO:0032332,GO:0032924,GO:0035788,GO:0042802,GO:0045444,GO:0045666,GO:0045893,GO:0060391,GO:0060395,GO:0060395,GO:1900745,GO:1990009

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GDF6 hsa:392255 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
GDF6 hsa:392255 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
GDF6 hsa:392255 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GDF6 GDF6 16049014 26467481 bind,up-regulates N/A Signor
GDF6 BMPR2 16446785 18988627 23331499 9525338 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 GDF6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GDF6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C GDF6 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 GDF6 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA GDF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GDF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GDF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GDF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GDF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000250A40 GDF6 23706177 25416803 26701625 27292025 27418678 mrna cleavage,inhibition clip TarBase
URS00004214BB GDF6 23706177 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002F0130 GDF6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B GDF6 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SMAD1 GDF6 14525934 15246821 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD5 GDF6 14525934 15246821 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
BMPR2 GDF6 14525934 25348397 9525338 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMPR1B GDF6 14525934 25348397 9525338 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BMPR1A GDF6 14525934 25348397 9525338 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GDF6 BMPR1A 16049014 27898060 9525338 stimulant N/A OmniPath
GDF6 BMPR2 16049014 27898060 9525338 stimulant N/A OmniPath

Visualization










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