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GENE：RPS6KA3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RPS6KA3
FullNmae ribosomal protein S6 kinase A3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10432
EnsembleID ENSG00000177189
Uniprot P51812

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RPS6KA3 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RPS6KA3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RPS6KA3 GO:0000287,GO:0001501,GO:0002224,GO:0004672,GO:0004674,GO:0004711,GO:0005515,GO:0005524,GO:0005654,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005829,GO:0007049,GO:0007165,GO:0007268,GO:0007417,GO:0018105,GO:0018105,GO:0019901,GO:0030307,GO:0032496,GO:0035556,GO:0043027,GO:0043066,GO:0043154,GO:0043555,GO:0043620,GO:0045202,GO:0045597,GO:0045944,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RPS6KA3 hsa:6197 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04714 Thermogenesis - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04720 Long-term potentiation - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa04931 Insulin resistance - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa05135 Yersinia infection - Homo sapiens (human)
RPS6KA3 hsa:6197 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RPS6KA3 ESR1 11432835 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK1 RPS6KA3 12832467 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK3 RPS6KA3 12832467 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
KRT18 RPS6KA3 20005715 interaction type N/A PSP
MAGI1 RPS6KA3 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR RPS6KA3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 RPS6KA3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 RPS6KA3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 RPS6KA3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 RPS6KA3 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 RPS6KA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 RPS6KA3 11705993 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D RPS6KA3 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS000002103A RPS6KA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F6E49 RPS6KA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD RPS6KA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000076995 RPS6KA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004F4657 RPS6KA3 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 RPS6KA3 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00001310DE RPS6KA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000081D1E RPS6KA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003676C9 RPS6KA3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C RPS6KA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 RPS6KA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 RPS6KA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 RPS6KA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00007455B8 RPS6KA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D RPS6KA3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C RPS6KA3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 RPS6KA3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B2B5C RPS6KA3 25416803 25992613 mrna cleavage,inhibition array technology,experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SRC RPS6KA3 22135298 phosphorylation N/A PhosphoSite
MAPK1 RPS6KA3 22135298 phosphorylation N/A PhosphoSite
FGFR3 RPS6KA3 22135298 phosphorylation N/A PhosphoSite
FYN RPS6KA3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 NFATC4 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 MAP3K5 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 BAD 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 WWC1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 CASP8 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 CREB1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 GSK3B 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 RANBP3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 EIF2AK2 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 ESR1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 RPS6 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 YBX1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 TINF2 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 H3C1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 RRN3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 LCP1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 DAPK1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 TH 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 PPP1R3A 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 ATF4 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 STAT3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 H2BC3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 FGFR1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 STMN1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 EPHA2 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 SLC9A3 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 CIC 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 NFKBIA 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 EIF2S1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 GSK3A 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 KCNK3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
KRT18 RPS6KA3 1374067 14525934 25348397 7523419 N/A experimental interaction detection,in vitro ComPPI,HPRD
HSPA8 RPS6KA3 25348397 N/A physical interaction ComPPI
HSP90AB1 RPS6KA3 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
BAD RPS6KA3 11544290 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK1 RPS6KA3 12832467 14525934 21988832 23602568 24234451 25241761 25348397 9915826 association,physical association two hybrid,experimental interaction detection,physical interaction,in vivo,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
TMEM139 RPS6KA3 25348397 N/A physical interaction ComPPI
SRC RPS6KA3 25348397 N/A physical interaction ComPPI
SPRED2 RPS6KA3 25348397 N/A physical interaction ComPPI
NFATC1 RPS6KA3 25348397 N/A physical interaction ComPPI
MAPK3 RPS6KA3 12832467 14525934 24234451 25241761 25348397 9915826 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CREBBP RPS6KA3 11564891 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK14 RPS6KA3 25348397 N/A physical interaction ComPPI
FGFR2 RPS6KA3 25348397 N/A physical interaction ComPPI
SLC9A3R1 RPS6KA3 25348397 N/A physical interaction ComPPI
TGM2 RPS6KA3 25348397 N/A physical interaction ComPPI
HSP90AA1 RPS6KA3 25348397 N/A physical interaction ComPPI
NTRK1 RPS6KA3 25348397 N/A physical interaction ComPPI
ZMYM5 RPS6KA3 25348397 N/A physical interaction ComPPI
YBX1 RPS6KA3 25348397 N/A physical interaction ComPPI
MAGI1 RPS6KA3 14525934 16217014 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
PDPK1 RPS6KA3 10856237 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
STIP1 RPS6KA3 25348397 N/A physical interaction ComPPI
GBA RPS6KA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPT RPS6KA3 25348397 N/A physical interaction,protein kinase assay,in vitro ComPPI
NFKBIA RPS6KA3 25348397 N/A physical interaction ComPPI
RPS6KA3 NR4A1 14525934 16223362 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RPS6KA3 SHANK1 14525934 16217014 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
RPS6KA3 STK11 11297520 11853558 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RPS6KA3 GRIN2D 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RPS6KA3 H3-4 10436156 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RPS6KA3 PEA15 12796492 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RPS6KA3 GRIN1 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RPS6KA3 FGF2 14525934 15879597 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RPS6KA3 CREB1 11160957 11175347 14525934 25348397 8688081 9687510 9829964 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RPS6KA3 ESR1 11139588 11432835 11507039 14525934 25348397 9528769 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RPS6KA3 HTR2A 14525934 16537434 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
RPS6KA3 HMGN2 11438671 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RPS6KA3 HMGN1 10739259 11438671 12773393 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RPS6KA3 H2AX 25348397 N/A physical interaction ComPPI
RPS6KA3 NEDD4 25348397 N/A physical interaction ComPPI
RPS6KA3 EIF3C 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA3 ATP5PF 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA3 BARX1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA3 MASP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA3 SMS 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA3 TRAF2 25348397 N/A physical interaction ComPPI
RPS6KA3 HSP90AA2P 25348397 N/A physical interaction ComPPI
RPS6KA3 FGFR1 25348397 N/A physical interaction ComPPI
RPS6KA3 DFFA 25348397 N/A physical interaction ComPPI
RPS6KA3 NAPRT 25348397 N/A physical interaction ComPPI
RPS6KA3 CSE1L 25348397 N/A physical interaction ComPPI
RPS6KA3 GDA 25348397 N/A physical interaction ComPPI
RPS6KA3 NPEPPS 25348397 N/A physical interaction ComPPI
RPS6KA3 RPS6KA1 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RPS6KA3 EGFR 25348397 N/A physical interaction ComPPI
RPS6KA3 TRMT9B 25348397 N/A physical interaction ComPPI
RPS6KA3 HNRNPH1 25348397 N/A physical interaction ComPPI
RPS6KA3 CDC37 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RPS6KA3 MISP 25348397 N/A physical interaction ComPPI
RPS6KA3 FYN 25348397 N/A physical interaction ComPPI
RPS6KA3 TRIM11 25348397 N/A physical interaction ComPPI
RPS6KA3 IL17RA 25348397 N/A physical interaction ComPPI
RPS6KA3 NTAQ1 25348397 N/A physical interaction ComPPI
RPS6KA3 PPP6R2 25348397 N/A physical interaction ComPPI
RPS6KA3 STRADB 25348397 N/A physical interaction ComPPI
RPS6KA3 NDEL1 25348397 N/A physical interaction ComPPI
RPS6KA3 IRGC 25348397 N/A physical interaction ComPPI
RPS6KA3 ILKAP 25348397 N/A physical interaction ComPPI
RPS6KA3 FGFR3 25348397 N/A physical interaction ComPPI
RPS6KA3 PLD1 18550821 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RPS6KA3 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPS6KA3 GSTK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPS6KA3 CSNK2B 10094392 24234451 25348397 physical association two hybrid ComPPI,IntAct
PKM RPS6KA3 25348397 N/A protein kinase assay ComPPI
H3C1 RPS6KA3 25348397 N/A physical interaction ComPPI
RPS6KA3 RPS6KA3 14525934 17192257 N/A experimental interaction detection HPRD
SRC RPS6KA3 18156174 27898060 stimulant N/A OmniPath
FYN RPS6KA3 18156174 27898060 stimulant N/A OmniPath
EGFR RPS6KA3 10980595 27898060 N/A N/A OmniPath
FGFR1 RPS6KA3 10980595 12601080 17785202 18156174 24141780 27898060 N/A N/A OmniPath
RPS6KA3 FGFR1 24141780 27898060 N/A N/A OmniPath
MAPKAPK2 RPS6KA3 18691976 19369195 27898060 N/A N/A OmniPath
RPS6KA3 HMGN2 11438671 27898060 inhibition N/A OmniPath
RPS6KA3 CREB1 11160957 11175347 11698596 27898060 8688081 9687510 9829964 stimulant N/A OmniPath
RPS6KA3 H3-4 10436156 27898060 stimulant N/A OmniPath
RPS6KA3 EIF2AK2 11337501 15880455 17404396 27898060 stimulant N/A OmniPath
RPS6KA3 STK11 11297520 11853558 27898060 N/A N/A OmniPath
RPS6KA3 ESR1 11139588 11432835 11507039 19112174 27898060 9528769 stimulant N/A OmniPath
RPS6KA3 BAD 10558990 10976111 11544290 11983683 19282669 27898060 inhibition N/A OmniPath
PDPK1 RPS6KA3 10480933 10856237 17906627 19956600 25241761 27898060 stimulant N/A OmniPath
RPS6KA3 PDPK1 10856237 17906627 25241761 27898060 stimulant N/A OmniPath
RPS6KA3 H3C1 10436156 10464286 14625384 15994958 27898060 stimulant N/A OmniPath
RPS6KA3 GSK3A 11583116 27898060 inhibition N/A OmniPath
RPS6KA3 NR4A1 11274386 16223362 18669648 27898060 N/A N/A OmniPath
MAPK3 RPS6KA3 10980595 12832467 17906627 19282669 25241761 27898060 8939914 9915826 stimulant N/A OmniPath
RPS6KA3 MAPK3 12832467 25241761 27898060 8939914 9915826 N/A N/A OmniPath
RPS6KA3 YBX1 15806160 17704806 19036157 20844753 21423216 24335958 26318844 27898060 stimulant N/A OmniPath
PPM1D RPS6KA3 15206906 27898060 N/A N/A OmniPath
RPS6KA3 TSC2 16244323 27898060 inhibition N/A OmniPath
MAPK1 RPS6KA3 12016217 12832467 17906627 19282669 21988832 23602568 25241761 27898060 8939914 9915826 stimulant N/A OmniPath
RPS6KA3 MAPK1 12016217 12832467 21988832 23602568 25241761 27898060 8939914 9915826 N/A N/A OmniPath
PPP2CA RPS6KA3 27898060 7623830 N/A N/A OmniPath
RPS6KA3 KRT18 1374067 17924679 18669648 19007248 20068231 27898060 7523419 N/A N/A OmniPath
RPS6KA3 RPTOR 18722121 27898060 stimulant N/A OmniPath
RPS6KA3 RPS6 10748124 15358595 16301994 16641152 17220300 17334390 18283331 18342602 19203585 19487463 20039704 20691662 21242970 21601007 21726807 21763421 21819957 22167413 24081491 24998849 25020061 25500539 25738361 25893295 25894744 26340096 27898060 stimulant N/A OmniPath
RPS6KA3 DAPK1 16213824 27898060 inhibition N/A OmniPath
RPS6KA3 TINF2 23977114 27898060 N/A N/A OmniPath
RPS6KA3 HMGN1 10739259 11438671 12773393 17924679 20068231 20166139 27898060 inhibition N/A OmniPath
RPS6KA3 ATF4 15109498 22052162 23975372 27898060 stimulant N/A OmniPath
RPS6KA3 NFATC4 15657420 17081983 17213202 18220336 27898060 stimulant N/A OmniPath
RPS6KA3 H3-3A 10464286 14625384 15994958 27898060 stimulant N/A OmniPath
RPS6KA3 METTL1 15861136 27898060 N/A N/A OmniPath
RPS6KA3 WWC1 24269383 27898060 stimulant N/A OmniPath
RPS6KA3 PFKFB2 27898060 2846551 9211863 stimulant N/A OmniPath
FLT4 RPS6KA3 12601080 27898060 inhibition N/A OmniPath
RPS6KA3 TH 12421349 27898060 7901013 stimulant N/A OmniPath
RPS6KA3 RRN3 15558034 18498750 27898060 N/A N/A OmniPath
RPS6KA3 KCNK3 21357689 21838752 27898060 stimulant N/A OmniPath
PPP2CB RPS6KA3 27898060 7623830 N/A N/A OmniPath
RPS6KA3 CIC 21087211 27898060 inhibition N/A OmniPath
RPS6KA3 H2BC3 21646345 27898060 stimulant N/A OmniPath

Visualization










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