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GENE：PLA2G4E

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLA2G4E
FullNmae phospholipase A2 group IVE
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24791
EnsembleID ENSG00000188089
Uniprot Q3MJ16

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLA2G4E apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLA2G4E GO:0005509,GO:0005544,GO:0005546,GO:0005547,GO:0005765,GO:0005829,GO:0005829,GO:0005886,GO:0008970,GO:0010314,GO:0016410,GO:0031901,GO:0032266,GO:0036149,GO:0043325,GO:0046475,GO:0047498,GO:0070273,GO:0070292,GO:0080025,GO:2001137

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLA2G4E hsa:123745 path:hsa00564 Glycerophospholipid metabolism - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa00565 Ether lipid metabolism - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa00591 Linoleic acid metabolism - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa00592 alpha-Linolenic acid metabolism - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04217 Necroptosis - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04611 Platelet activation - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04730 Long-term depression - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04913 Ovarian steroidogenesis - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PLA2G4E hsa:123745 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOXP3 PLA2G4E 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PLA2G4E 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000002569A PLA2G4E 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF PLA2G4E 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 PLA2G4E 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TBC1D22B PLA2G4E 25348397 N/A physical interaction ComPPI

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