GENE:PPP3CB
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | PPP3CB |
FullNmae | protein phosphatase 3 catalytic subunit beta |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:9315 |
EnsembleID | ENSG00000107758 |
Uniprot | P16298 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
PPP3CB | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PPP3CB | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
PPP3CB | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
PPP3CB | GO:0001913,GO:0001915,GO:0001946,GO:0004722,GO:0005509,GO:0005515,GO:0005516,GO:0005516,GO:0005516,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005955,GO:0005955,GO:0005955,GO:0006468,GO:0006470,GO:0006470,GO:0007165,GO:0007507,GO:0007612,GO:0007613,GO:0008287,GO:0016311,GO:0017018,GO:0017156,GO:0019899,GO:0023057,GO:0030018,GO:0030217,GO:0030315,GO:0030346,GO:0031987,GO:0033173,GO:0033192,GO:0033192,GO:0033192,GO:0033192,GO:0034097,GO:0035774,GO:0042098,GO:0042110,GO:0043029,GO:0045893,GO:0045944,GO:0046983,GO:0048167,GO:0048675,GO:0048741,GO:0050796,GO:0070886,GO:0097720,GO:0097720,GO:0098978,GO:1900182,GO:1900242,GO:1905665,GO:1905673,GO:1905949 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
PPP3CB | hsa:5532 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05020 | Prion disease - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05031 | Amphetamine addiction - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05152 | Tuberculosis - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human) |
PPP3CB | hsa:5532 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | PPP3CB | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ETS1 | PPP3CB | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
YBX1 | PPP3CB | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
FOXP3 | PPP3CB | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
SMARCA4 | PPP3CB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | PPP3CB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | PPP3CB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | PPP3CB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | PPP3CB | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS00004AC389 | PPP3CB | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS0000076995 | PPP3CB | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001DE669 | PPP3CB | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000005CF5F | PPP3CB | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000065D58 | PPP3CB | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002152A8 | PPP3CB | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001B12A4 | PPP3CB | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000331800 | PPP3CB | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DD591 | PPP3CB | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MYOZ2 | PPP3CB | 25361965 | interaction type | N/A | PTMCode2 |
PPP3CB | MYOZ2 | 25361965 | interaction type | N/A | PTMCode2 |
MYOZ1 | PPP3CB | 25361965 | interaction type | N/A | PTMCode2 |
PPP3CB | MYOZ1 | 25361965 | interaction type | N/A | PTMCode2 |
JUN | PPP3CB | 25361965 | interaction type | N/A | PTMCode2 |
PPP3CB | JUN | 25361965 | interaction type | N/A | PTMCode2 |
PPP3R1 | PPP3CB | 25361965 | interaction type | N/A | PTMCode2 |
PPP3CB | PPP3R1 | 25361965 | interaction type | N/A | PTMCode2 |
PPP3CB | NFATC2 | 25361965 | interaction type | N/A | PTMCode2 |
NFATC2 | PPP3CB | 25361965 | interaction type | N/A | PTMCode2 |
CABIN1 | PPP3CB | 25361965 | interaction type | N/A | PTMCode2 |
PPP3CB | CABIN1 | 25361965 | interaction type | N/A | PTMCode2 |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
RBM17 | PPP3CB | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
SOCS3 | PPP3CB | 11970967 25348397 27898060 | N/A | in vitro,in vivo | ComPPI,OmniPath |
PPP1R13B | PPP3CB | 24234451 24366813 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
ROR2 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
PPP1CC | PPP3CB | 24234451 24366813 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
GABARAPL2 | PPP3CB | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
CALM1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
CDR2 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
COX5A | PPP3CB | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MYOZ2 | PPP3CB | 11114196 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
ZYX | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
GRB2 | PPP3CB | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
JUN | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
PPP1R3A | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
GSK3A | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
MYOZ3 | PPP3CB | 25348397 | N/A | in vivo | ComPPI |
PDE4D | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
IRAK1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
NFATC2 | PPP3CB | 25348397 | N/A | in vitro,in vivo | ComPPI |
AHNAK | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
PDHB | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
RAD51 | PPP3CB | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
SLC8A1 | PPP3CB | 25348397 | N/A | two hybrid,in vivo | ComPPI |
EGFR | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
RASSF2 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
WDR12 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
TUBGCP3 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
HSPA9 | PPP3CB | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
TFEB | PPP3CB | 24234451 25348397 25720963 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
CABIN1 | PPP3CB | 25348397 | N/A | two hybrid,in vivo | ComPPI |
ELAVL1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
SRSF5 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
PPP3R1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
MLH1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
LMTK2 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
RCAN1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
RCAN2 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | SLC8A2 | 25348397 | N/A | in vivo | ComPPI |
PPP3CB | SLC8A3 | 25348397 | N/A | in vivo | ComPPI |
PPP3CB | IRF2 | 21903422 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PPP3CB | ATG7 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | VPS36 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | DNAAF10 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | MARCHF7 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | CEP76 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | RCAN3 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | RSRC1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PPP3CB | PHF5A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
PPP3CB | ARMT1 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | LBH | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | PI4KA | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | TMEM200A | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | DEFA1 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | KLRG2 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | CRTC2 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | AATK | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | PTK7 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | TRIM16 | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | TBC1D10C | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
PPP3CB | CACNA1H | 23669360 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct,OmniPath |
VPS25 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
PPP3CB | DNM1 | 20496096 27898060 8052858 | stimulant | N/A | OmniPath |
PPP3CB | PRKAR2A | 27898060 9660947 | N/A | N/A | OmniPath |
PPP3CB | VASP | 27898060 7656973 | N/A | N/A | OmniPath |
PPP3CB | FLNA | 16442073 27898060 | inhibition | N/A | OmniPath |
PPP3CB | PPP1R1B | 10217279 12065642 27898060 | N/A | N/A | OmniPath |
PPP3CB | CSNK1E | 27898060 9430669 | N/A | N/A | OmniPath |
PPP3CB | DNM2 | 20496096 27898060 | N/A | N/A | OmniPath |
PPP3CB | KSR2 | 19560418 27898060 | N/A | N/A | OmniPath |
PPP3CB | BAD | 10195903 22820751 27898060 | stimulant | N/A | OmniPath |
PPP3CB | CRYAA | 2548498 27898060 | N/A | N/A | OmniPath |
PPP3CB | RCAN1 | 12063245 27898060 | N/A | N/A | OmniPath |
PPP3CB | MAPT | 15959850 16262633 27898060 9660947 | N/A | N/A | OmniPath |
PPP3CB | GSK3B | 19659461 27898060 | N/A | N/A | OmniPath |
PPP3CB | HSPB1 | 27898060 7510704 | N/A | N/A | OmniPath |
IRAK1 | PPP3CB | 21903422 27898060 | N/A | N/A | OmniPath |
PPP3CB | JUN | 17215518 17952113 27898060 | N/A | N/A | OmniPath |
PPP3CB | NFATC2 | 11030334 11062529 18676376 27898060 9660947 | stimulant | N/A | OmniPath |
IRF2 | PPP3CB | 21903422 27898060 | N/A | N/A | OmniPath |
PPP3CB | IRF2 | 21903422 27898060 | N/A | N/A | OmniPath |
PPP3CB | ELK1 | 10329725 27898060 | N/A | N/A | OmniPath |
PPP3CB | NFATC1 | 11062529 27898060 | stimulant | N/A | OmniPath |
PPP3CB | PPP1R1A | 11278334 27898060 | N/A | N/A | OmniPath |
PPP3CB | NEFH | 20031277 27898060 | N/A | N/A | OmniPath |
PPP3CB | TFEB | 26000950 27898060 | stimulant | N/A | OmniPath |
PPP3CB | CANX | 20700529 27898060 | N/A | N/A | OmniPath |
PPP3CB | DNM1L | 17721437 18838687 27898060 | stimulant | N/A | OmniPath |
PPP3CB | SSH1 | 15671020 27898060 | N/A | N/A | OmniPath |
PPP3CB | GAD1 | 15147202 27898060 7896780 | N/A | N/A | OmniPath |
PPP3CB | GAD2 | 15147202 27898060 | N/A | N/A | OmniPath |
PPP3CB | SLC10A1 | 12065290 27898060 | N/A | N/A | OmniPath |