Gene Information gene info

GENE:PPP3CB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PPP3CB
FullNmae protein phosphatase 3 catalytic subunit beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9315
EnsembleID ENSG00000107758
Uniprot P16298

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PPP3CB pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP3CB immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PPP3CB apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PPP3CB GO:0001913,GO:0001915,GO:0001946,GO:0004722,GO:0005509,GO:0005515,GO:0005516,GO:0005516,GO:0005516,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0005955,GO:0005955,GO:0005955,GO:0006468,GO:0006470,GO:0006470,GO:0007165,GO:0007507,GO:0007612,GO:0007613,GO:0008287,GO:0016311,GO:0017018,GO:0017156,GO:0019899,GO:0023057,GO:0030018,GO:0030217,GO:0030315,GO:0030346,GO:0031987,GO:0033173,GO:0033192,GO:0033192,GO:0033192,GO:0033192,GO:0034097,GO:0035774,GO:0042098,GO:0042110,GO:0043029,GO:0045893,GO:0045944,GO:0046983,GO:0048167,GO:0048675,GO:0048741,GO:0050796,GO:0070886,GO:0097720,GO:0097720,GO:0098978,GO:1900182,GO:1900242,GO:1905665,GO:1905673,GO:1905949

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PPP3CB hsa:5532 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04218 Cellular senescence - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04360 Axon guidance - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04662 B cell receptor signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04720 Long-term potentiation - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa04924 Renin secretion - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05020 Prion disease - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05152 Tuberculosis - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)
PPP3CB hsa:5532 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PPP3CB PPP3R1 10195903 11015619 18296442 24243840 26192618 29145629 7593193 association,physical association inferred by curator ACSN,Reactome
PPP3CB CSE1L 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19836308 21983832 26192618 7650486 8068174 9374532 9973469 interaction type N/A ACSN
PPP3CB KPNB1 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19136967 19836308 21278340 21709260 21983832 26192618 7650486 8068174 9374532 9973469 interaction type N/A ACSN
PPP3CB LRRK2 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19836308 21709260 21983832 26192618 7650486 8068174 9374532 9973469 interaction type N/A ACSN
PPP3CB TNPO1 10089876 10811803 10898494 11030334 11148124 11262396 11274345 11402342 11406367 18287025 19136967 19836308 21278340 21709260 21983832 26192618 7650486 8068174 9374532 9973469 interaction type N/A ACSN
PPP3CB BAD 10089876 11796223 14741051 15036616 17593948 18235236 19136967 19608982 2550447 26192618 7650486 9973469 interaction type N/A ACSN
PPP3CB TAB1 10089876 10391247 11274345 11796223 12620219 14660645 14741051 15036616 15082531 17593948 18235236 18264787 18855897 19136967 19608982 23070005 2550447 26192618 7650486 9973469 interaction type N/A ACSN
PPP3CB TAB2 10089876 10391247 11274345 11796223 12620219 14660645 14741051 15036616 15082531 17593948 18235236 18264787 18855897 19136967 19608982 23070005 2550447 26192618 7650486 9973469 interaction type N/A ACSN
CUL1 PPP3CB 11900249 12648680 12820959 15071497 15340381 15459660 15489953 15688063 15703371 16697054 17884153 18931676 19622404 19686080 19809470 19847258 26192618 interaction type N/A ACSN
RBX1 PPP3CB 11900249 12648680 12820959 15071497 15340381 15459660 15489953 15688063 15703371 16697054 17884153 18931676 19622404 19686080 19809470 19847258 26192618 interaction type N/A ACSN
SKP1 PPP3CB 11900249 12648680 12820959 15071497 15340381 15459660 15489953 15688063 15703371 16697054 17884153 18931676 19622404 19686080 19809470 19847258 26192618 interaction type N/A ACSN
IRAK1 PPP3CB 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF2 PPP3CB 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB
PPP3CB ELAVL1 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFATC1 PPP3CB 10860980 11030334 12015605 12975316 16880514 16920709 17502104 19851316 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome
PPP3CB NFATC3 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome
PPP3CB NFATC2 10860980 11030334 12975316 17502104 29145629 8576111 8631904 8799126 9727000 physical association inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
AR PPP3CB 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PPP3CB 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PPP3CB 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PPP3CB 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PPP3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PPP3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PPP3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PPP3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PPP3CB 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004AC389 PPP3CB 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000076995 PPP3CB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 PPP3CB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F PPP3CB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 PPP3CB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PPP3CB 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 PPP3CB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000331800 PPP3CB 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 PPP3CB 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MYOZ2 PPP3CB 25361965 interaction type N/A PTMCode2
PPP3CB MYOZ2 25361965 interaction type N/A PTMCode2
MYOZ1 PPP3CB 25361965 interaction type N/A PTMCode2
PPP3CB MYOZ1 25361965 interaction type N/A PTMCode2
JUN PPP3CB 25361965 interaction type N/A PTMCode2
PPP3CB JUN 25361965 interaction type N/A PTMCode2
PPP3R1 PPP3CB 25361965 interaction type N/A PTMCode2
PPP3CB PPP3R1 25361965 interaction type N/A PTMCode2
PPP3CB NFATC2 25361965 interaction type N/A PTMCode2
NFATC2 PPP3CB 25361965 interaction type N/A PTMCode2
CABIN1 PPP3CB 25361965 interaction type N/A PTMCode2
PPP3CB CABIN1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RBM17 PPP3CB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SOCS3 PPP3CB 11970967 25348397 27898060 N/A in vitro,in vivo ComPPI,OmniPath
PPP1R13B PPP3CB 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROR2 PPP3CB 25348397 N/A physical interaction ComPPI
PPP1CC PPP3CB 24234451 24366813 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GABARAPL2 PPP3CB 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CALM1 PPP3CB 25348397 N/A physical interaction ComPPI
CDR2 PPP3CB 25348397 N/A physical interaction ComPPI
COX5A PPP3CB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MYOZ2 PPP3CB 11114196 25348397 27898060 N/A in vivo ComPPI,OmniPath
ZYX PPP3CB 25348397 N/A physical interaction ComPPI
GRB2 PPP3CB 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
JUN PPP3CB 25348397 N/A physical interaction ComPPI
PPP1R3A PPP3CB 25348397 N/A physical interaction ComPPI
GSK3A PPP3CB 25348397 N/A physical interaction ComPPI
MYOZ3 PPP3CB 25348397 N/A in vivo ComPPI
PDE4D PPP3CB 25348397 N/A physical interaction ComPPI
IRAK1 PPP3CB 25348397 N/A physical interaction ComPPI
NFATC2 PPP3CB 25348397 N/A in vitro,in vivo ComPPI
AHNAK PPP3CB 25348397 N/A physical interaction ComPPI
PDHB PPP3CB 25348397 N/A physical interaction ComPPI
RAD51 PPP3CB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC8A1 PPP3CB 25348397 N/A two hybrid,in vivo ComPPI
EGFR PPP3CB 25348397 N/A physical interaction ComPPI
RASSF2 PPP3CB 25348397 N/A physical interaction ComPPI
WDR12 PPP3CB 25348397 N/A physical interaction ComPPI
TUBGCP3 PPP3CB 25348397 N/A physical interaction ComPPI
HSPA9 PPP3CB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFEB PPP3CB 24234451 25348397 25720963 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CABIN1 PPP3CB 25348397 N/A two hybrid,in vivo ComPPI
ELAVL1 PPP3CB 25348397 N/A physical interaction ComPPI
SRSF5 PPP3CB 25348397 N/A physical interaction ComPPI
PPP3R1 PPP3CB 25348397 N/A physical interaction ComPPI
MLH1 PPP3CB 25348397 N/A physical interaction ComPPI
LMTK2 PPP3CB 25348397 N/A physical interaction ComPPI
RCAN1 PPP3CB 25348397 N/A physical interaction ComPPI
RCAN2 PPP3CB 25348397 N/A physical interaction ComPPI
PPP3CB SLC8A2 25348397 N/A in vivo ComPPI
PPP3CB SLC8A3 25348397 N/A in vivo ComPPI
PPP3CB IRF2 21903422 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP3CB ATG7 25348397 N/A physical interaction ComPPI
PPP3CB VPS36 25348397 N/A physical interaction ComPPI
PPP3CB DNAAF10 25348397 N/A physical interaction ComPPI
PPP3CB MARCHF7 25348397 N/A physical interaction ComPPI
PPP3CB CEP76 25348397 N/A physical interaction ComPPI
PPP3CB RCAN3 25348397 N/A physical interaction ComPPI
PPP3CB PPP3CC 25348397 N/A physical interaction ComPPI
PPP3CB RSRC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP3CB PHF5A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP3CB ARMT1 25348397 N/A physical interaction ComPPI
PPP3CB LBH 25348397 N/A physical interaction ComPPI
PPP3CB PI4KA 25348397 N/A physical interaction ComPPI
PPP3CB TMEM200A 25348397 N/A physical interaction ComPPI
PPP3CB DEFA1 25348397 N/A physical interaction ComPPI
PPP3CB KLRG2 25348397 N/A physical interaction ComPPI
PPP3CB CRTC2 25348397 N/A physical interaction ComPPI
PPP3CB AATK 25348397 N/A physical interaction ComPPI
PPP3CB PTK7 25348397 N/A physical interaction ComPPI
PPP3CB TRIM16 25348397 N/A physical interaction ComPPI
PPP3CB TBC1D10C 25348397 N/A two hybrid,physical interaction ComPPI
PPP3CB CACNA1H 23669360 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
VPS25 PPP3CB 25348397 N/A physical interaction ComPPI
PPP3CB DNM1 20496096 27898060 8052858 stimulant N/A OmniPath
PPP3CB PRKAR2A 27898060 9660947 N/A N/A OmniPath
PPP3CB VASP 27898060 7656973 N/A N/A OmniPath
PPP3CB FLNA 16442073 27898060 inhibition N/A OmniPath
PPP3CB PPP1R1B 10217279 12065642 27898060 N/A N/A OmniPath
PPP3CB CSNK1E 27898060 9430669 N/A N/A OmniPath
PPP3CB DNM2 20496096 27898060 N/A N/A OmniPath
PPP3CB KSR2 19560418 27898060 N/A N/A OmniPath
PPP3CB BAD 10195903 22820751 27898060 stimulant N/A OmniPath
PPP3CB CRYAA 2548498 27898060 N/A N/A OmniPath
PPP3CB RCAN1 12063245 27898060 N/A N/A OmniPath
PPP3CB MAPT 15959850 16262633 27898060 9660947 N/A N/A OmniPath
PPP3CB GSK3B 19659461 27898060 N/A N/A OmniPath
PPP3CB HSPB1 27898060 7510704 N/A N/A OmniPath
IRAK1 PPP3CB 21903422 27898060 N/A N/A OmniPath
PPP3CB JUN 17215518 17952113 27898060 N/A N/A OmniPath
PPP3CB NFATC2 11030334 11062529 18676376 27898060 9660947 stimulant N/A OmniPath
IRF2 PPP3CB 21903422 27898060 N/A N/A OmniPath
PPP3CB IRF2 21903422 27898060 N/A N/A OmniPath
PPP3CB ELK1 10329725 27898060 N/A N/A OmniPath
PPP3CB NFATC1 11062529 27898060 stimulant N/A OmniPath
PPP3CB PPP1R1A 11278334 27898060 N/A N/A OmniPath
PPP3CB NEFH 20031277 27898060 N/A N/A OmniPath
PPP3CB TFEB 26000950 27898060 stimulant N/A OmniPath
PPP3CB CANX 20700529 27898060 N/A N/A OmniPath
PPP3CB DNM1L 17721437 18838687 27898060 stimulant N/A OmniPath
PPP3CB SSH1 15671020 27898060 N/A N/A OmniPath
PPP3CB GAD1 15147202 27898060 7896780 N/A N/A OmniPath
PPP3CB GAD2 15147202 27898060 N/A N/A OmniPath
PPP3CB SLC10A1 12065290 27898060 N/A N/A OmniPath

Visualization