Gene Information gene info

GENE:PRKCG

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKCG
FullNmae protein kinase C gamma
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9402
EnsembleID ENSG00000126583
Uniprot P05129

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKCG parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKCG necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKCG apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKCG GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0004712,GO:0005515,GO:0005524,GO:0005634,GO:0005829,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0007268,GO:0007611,GO:0007635,GO:0008270,GO:0009636,GO:0014069,GO:0016310,GO:0018105,GO:0030425,GO:0031397,GO:0032095,GO:0032425,GO:0035556,GO:0042177,GO:0042752,GO:0043278,GO:0043524,GO:0044305,GO:0048265,GO:0048471,GO:0048511,GO:0050764,GO:0060291,GO:0060384,GO:0097060,GO:0099171,GO:0099523,GO:0099524,GO:0106310,GO:1901799,GO:1990911,GO:2000300

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKCG hsa:5582 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04370 VEGF signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04510 Focal adhesion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04540 Gap junction - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04713 Circadian entrainment - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04720 Long-term potentiation - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04727 GABAergic synapse - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04730 Long-term depression - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04911 Insulin secretion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04916 Melanogenesis - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04929 GnRH secretion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04970 Salivary secretion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05032 Morphine addiction - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05146 Amoebiasis - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05161 Hepatitis B - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05200 Pathways in cancer - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05214 Glioma - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05231 Choline metabolism in cancer - Homo sapiens (human)
PRKCG hsa:5582 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP2K4 PRKCG 11335711 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT3 PRKCG 11335711 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
DVL2 PRKCG 20005715 interaction type N/A PSP
GJA1 PRKCG 20005715 interaction type N/A PSP
IRS1 PRKCG 20005715 interaction type N/A PSP
NRGN PRKCG 20005715 interaction type N/A PSP
PARD3 PRKCG 20005715 interaction type N/A PSP
YWHAB PRKCG 20005715 interaction type N/A PSP
YWHAE PRKCG 20005715 interaction type N/A PSP
YWHAG PRKCG 20005715 interaction type N/A PSP
DVL2 PRKCG 20005715 N/A N/A SignaLink
YWHAB PRKCG 14676191 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 PRKCG 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PRKCG 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF PRKCG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKCG 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PRKCG 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PRKCG HSP90AA1 22135298 phosphorylation N/A PhosphoSite
PRKCG DAB2 22135298 phosphorylation N/A PhosphoSite
PRKCG KCNC4 22135298 phosphorylation N/A PhosphoSite
PRKCG KIR3DL1 22135298 phosphorylation N/A PhosphoSite
PRKCG GSK3B 22135298 phosphorylation N/A PhosphoSite
PRKCG MMP14 22135298 phosphorylation N/A PhosphoSite
PRKCG RPS6KB2 22135298 phosphorylation N/A PhosphoSite
PRKCG ARHGEF7 22135298 phosphorylation N/A PhosphoSite
PRKCG GRK2 22135298 phosphorylation N/A PhosphoSite
PRKCG C5AR1 22135298 phosphorylation N/A PhosphoSite
PRKCG APTX 22135298 phosphorylation N/A PhosphoSite
PRKCG CD5 22135298 phosphorylation N/A PhosphoSite
PRKCG NGFR 22135298 phosphorylation N/A PhosphoSite
PRKCG GSK3A 22135298 phosphorylation N/A PhosphoSite
PARD6A PRKCG 25361965 interaction type N/A PTMCode2
PRKCG PARD6A 25361965 interaction type N/A PTMCode2
PRKCG GRIA1 25361965 interaction type N/A PTMCode2
GRIA1 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG GJA1 25361965 interaction type N/A PTMCode2
GJA1 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG NRGN 25361965 interaction type N/A PTMCode2
NRGN PRKCG 25361965 interaction type N/A PTMCode2
PRKCG YWHAB 25361965 interaction type N/A PTMCode2
YWHAB PRKCG 25361965 interaction type N/A PTMCode2
PRKCG CDC42 25361965 interaction type N/A PTMCode2
CDC42 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG PNMA1 25361965 interaction type N/A PTMCode2
PNMA1 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG PARD6B 25361965 interaction type N/A PTMCode2
PARD6B PRKCG 25361965 interaction type N/A PTMCode2
PRKCG PARD3 25361965 interaction type N/A PTMCode2
PARD3 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG CYTH2 25361965 interaction type N/A PTMCode2
CYTH2 PRKCG 25361965 interaction type N/A PTMCode2
RGS2 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG RGS2 25361965 interaction type N/A PTMCode2
GJA3 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG GJA3 25361965 interaction type N/A PTMCode2
PEBP1 PRKCG 25361965 interaction type N/A PTMCode2
PRKCG PEBP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOC5 PRKCG 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CDC42 PRKCG 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
YWHAG PRKCG 10433554 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSP90AB1 PRKCG 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
PNMA1 PRKCG 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PICK1 PRKCG 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DAB2 PRKCG 10542228 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
OCLN PRKCG 11502742 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TIAM1 PRKCG 10212259 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKCA PRKCG 25348397 N/A physical interaction ComPPI
CD5 PRKCG 11123317 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NFE2L2 PRKCG 25348397 N/A physical interaction ComPPI
ARHGEF25 PRKCG 25348397 N/A physical interaction ComPPI
SDC2 PRKCG 14525934 25348397 9244383 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YWHAB PRKCG 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSP90AA1 PRKCG 25348397 N/A physical interaction ComPPI
VTN PRKCG 14525934 25348397 9030777 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPN1 PRKCG 17092689 24234451 25348397 physical association bimolecular fluorescence complementation ComPPI,IntAct
NUMB PRKCG 14525934 17203073 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PEBP1 PRKCG 12551925 14525934 14654844 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB2 PRKCG 25348397 N/A physical interaction ComPPI
RGS2 PRKCG 11063746 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASR PRKCG 14525934 25348397 9694886 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PA2G4 PRKCG 11325528 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NRGN PRKCG 14525934 25348397 8080473 N/A experimental interaction detection,in vitro ComPPI,HPRD
CYTH2 PRKCG 10531036 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STXBP1 PRKCG 12519779 12950453 14525934 25348397 8631738 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GSK3A PRKCG 11035810 11749387 11884598 12054501 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CHAT PRKCG 14525934 15381704 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
AFAP1 PRKCG 12134071 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HABP4 PRKCG 14525934 14699138 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPP1R14A PRKCG 14525934 15003508 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRIN2D PRKCG 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PDLIM5 PRKCG 25348397 N/A two hybrid ComPPI
GRIN1 PRKCG 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SCN3A PRKCG 25348397 N/A physical interaction ComPPI
PRKCG PKHD1 25348397 N/A in vivo ComPPI
PRKCG PARD3 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCG PARD6A 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCG GABRA4 12091471 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCG MARK4 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCG PARD6B 14525934 14676191 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCG GRK2 11042191 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCG NOXA1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKCG GRM5 25348397 N/A in vitro ComPPI
PRKCG IRS1 14525934 15364919 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCG GJA1 10871288 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCG DVL2 12958364 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCG TOP2A 12569090 14525934 25348397 7499337 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCG YWHAE 14525934 15459208 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCG EIF4E 14525934 25348397 8662663 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCG GABRA1 12091471 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCG GRIA4 12471040 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRKCG GRIN2B 11306676 12147342 14525934 25348397 8940188 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCG DDX58 25348397 N/A physical interaction ComPPI
PRKCG IBTK 25348397 N/A physical interaction ComPPI
PRKCG CCHCR1 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PRKCG APP 25348397 N/A physical interaction ComPPI
PRKCG HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKCG RANBP10 20395553 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PRKCG GFAP 25348397 N/A physical interaction ComPPI
PRKCG HSPA4 25348397 N/A physical interaction ComPPI
PRKCG EPHB1 25348397 N/A physical interaction ComPPI
PRKCG TRIM5 25348397 N/A physical interaction ComPPI
PRKCG RANBP9 25348397 N/A physical interaction ComPPI
PRKCG CTNNB1 25348397 N/A physical interaction ComPPI
PRKCG SMURF1 25348397 N/A physical interaction ComPPI
PRKCG UBE2T 25348397 N/A physical interaction ComPPI
GJA3 PRKCG 14525934 15467523 N/A experimental interaction detection HPRD
ANXA7 PRKCG 11278415 14525934 N/A experimental interaction detection HPRD
PRKCG GJA1 10871288 15459208 27898060 N/A N/A OmniPath
PRKCG ANXA1 24103589 27898060 stimulant N/A OmniPath
PRKCG TNNI3 15769444 27898060 inhibition N/A OmniPath
PRKCG GRIN2B 11306676 12147342 27898060 8940188 N/A N/A OmniPath
PRKCG NOS3 24379783 27898060 inhibition N/A OmniPath
PRKCG MMP14 19458085 22002060 22315223 27898060 N/A N/A OmniPath
PRKCG APTX 19561170 27898060 stimulant N/A OmniPath
PDPK1 PRKCG 15209375 17053865 27898060 stimulant N/A OmniPath
PRKCG PEBP1 12551925 14654844 20068231 20166139 27898060 stimulant N/A OmniPath
PRKCG MAP2K4 11335711 27898060 N/A N/A OmniPath
PRKCG GSK3A 11035810 11749387 11884598 12054501 18691976 19413330 27898060 inhibition N/A OmniPath
PDK1 PRKCG 17053865 27898060 stimulant N/A OmniPath
MAPK14 PRKCG 15964845 27898060 N/A N/A OmniPath
PRKCG HSP90AA1 24117238 27898060 inhibition N/A OmniPath
PRKCG RAF1 17053865 27898060 8288587 stimulant N/A OmniPath
PRKCG KEAP1 12198130 27898060 inhibition N/A OmniPath
PRKCG PSEN1 14576165 27898060 stimulant N/A OmniPath
PRKCG STAT3 11335711 27898060 N/A N/A OmniPath
PRKCG EIF4E 27898060 8662663 N/A N/A OmniPath
PRKCG TOP2A 12569090 18691976 19007248 19691289 27898060 7499337 stimulant N/A OmniPath
PRKCG DAB2 10542228 11812785 15280374 27898060 stimulant N/A OmniPath
PRKCG SDC2 19901323 27898060 9244383 N/A N/A OmniPath
PRKCG DVL2 12958364 27898060 stimulant N/A OmniPath
PRKCG NGFR 19710323 27898060 N/A N/A OmniPath
PRKCG ARHGEF7 25009260 27898060 stimulant N/A OmniPath
PRKCG GRK2 11042191 27898060 stimulant N/A OmniPath
PRKCG RPS6KB2 12529391 27898060 stimulant N/A OmniPath
PRKCG HABP4 14699138 27898060 inhibition N/A OmniPath
PRKCG CYTH2 10531036 27898060 inhibition N/A OmniPath
PRKCG PA2G4 11325528 20068231 27898060 N/A N/A OmniPath
PRKCG CHAT 15381704 27898060 stimulant N/A OmniPath
PRKCG KIR3DL1 17911614 27898060 inhibition N/A OmniPath
PRKCG KCNC4 27898060 9649584 N/A N/A OmniPath
PRKCG CD5 11123317 27898060 stimulant N/A OmniPath
PRKCG GRIA4 12471040 12536214 27898060 stimulant N/A OmniPath
PRKCG STXBP1 12519779 12950453 27898060 8631738 N/A N/A OmniPath

Visualization